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showing 10 items of 280 documents
A systematic review and combined analysis of therapeutic drug monitoring studies for longacting risperidone
2017
Introduction: This systematic review of therapeutic drug monitoring (TDM) identifies three long-acting injectable (LAI) risperidone formulations. Areas covered: Limited data is available on two formulations (RBP-7000 and in Situ Microparticle), but 20 TDM articles on the microsphere formulation were found. Risperidone TDM includes the serum concentrations of risperidone and its active metabolite, 9-hydroxyrisperidone, used for calculating: 1) the risperidone/9-hydroxyrisperidone (R/9-OH-R) ratio (a measure of CYP2D6; values >1 are indicative of a CYP2D6 poor metabolizer) and 2) the total risperidone concentration-to-dose (C/D) ratio (a measure of risperidone clearance with a normal value…
Binding of several phenothiazine neuroleptics to a common binding site of alpha 1-acid glycoprotein, orosomucoid.
1983
The interaction of several phenothiazine neuroleptics with alpha 1-acid glycoprotein was investigated using circular dichroism and equilibrium dialysis techniques. For chlorpromazine only, one high-affinity binding site of the protein was found. The binding of the drug to this single site generated typical polyphasic extrinsic Cotton effects. Since several other phenothiazine neuroleptics gave qualitatively comparable extrinsic Cotton effects in the presence of alpha 1-acid glycoprotein and potently inhibited the binding of chlorpromazine to the single site, it was concluded that all phenothiazine derivatives investigated bound preferentially to only one common binding site of the alpha 1-a…
In vitro P-glycoprotein efflux inhibition by atypical antipsychotics is in vivo nicely reflected by pharmacodynamic but less by pharmacokinetic chang…
2011
Abstract Background P-glycoprotein (P-gp), an efflux transporter of the blood–brain barrier, limits the access of multiple xenobiotics to the central nervous system (CNS). Thus drug-dependent inhibition, induction or genetic variation of P-gp impacts drug therapy. Methods We investigated atypical antipsychotics and their interaction with P-gp. Amisulpride, clozapine, N-desmethylclozapine, olanzapine, and quetiapine were assessed in vitro on their inhibitory potential and in vivo on their disposition in mouse serum and brain, and behaviourally on the RotaRod test. In vivo wildtype (WT) and mdr1a/1b double knockout mice (mdr1a/1b (−/−, −/−); KO) were investigated. Results In rhodamine 123 eff…
Tratamiento psicofarmacológico del trastorno bipolar en América Latina
2011
Objective: This study assessed the treatment preferences among Latin-American psychiatrists for their bipolar disorder patients and if these preferences reflect the current guidelines. Methods: We designed a survey comprised of fourteen questions. All the questions were aimed at the treatment of bipolar I patients only. We distributed the survey by hand or e-mail to psychiatrists in eight different countries: Argentina, Brasil, Colombia, Costa Rica, Ecuador, México, Perú and Venezuela. Between May 2008 and June 2009, we were able to gather 1143 surveys. Results: As the initial choice of treatment for a bipolar patient who debuts with mania, 61.3% choose a combination of an atypical antipsyc…
La representació de la diversitata social en els materials didàctics digitals
2018
Con la extensión del uso de Materiales Didácticos Digitales (MDD) en la Educación Primaria en España, es pertinente analizar cómo estos representan la diversidad funcional, sexual, cultural, étnico/cultural, etario o de género en nuestra sociedad. Ese es uno de los objetivos del proyecto La escuela de la sociedad digital: análisis y propuestas para la producción y uso de los contenidos digitales educativos, que se está desarrollando en España —concretamente en Galicia, Valencia e Islas Canarias—. La metodología de estudio ha sido mixta —cuantitativa y cualitativa—centrada en el análisis de una muestra de 56 MDD ubicados en plataformas on lineinstitucionales, comerciales y colaborativas proc…
Datortehnikas ražotāja produkta un vizuālās identitātes vizuāli stilistiskie aspekti
2016
Šī diplomdarba mērķis ir uzzināt vizuālās identitātes vizuāli stilistiskās īpašības datortehnikas uzņēmumiem, kas specializējas datorkorpusu ražošanā, kā arī izstrādāt vizuālo identitāti un produkta dizainu datorkorpusu ražotājkompānijai „Vulcan”. Darbā tiek izklāstīta vizuālās identitātes vēsture un attīstība līdz mūsdienām; tiek aprakstīta koloristikas, burtveidola, logotipa un stila grāmatas nozīme uzņēmuma zīmolam. Darba pētījumā tiek izmantota kvantitatīvā un kvalitatīvā analīzes metode, lai noskaidrotu vizuālās identitātes stilistiskos aspektus, ko izmanto datortehnikas uzņēmumi. Arī tiek veikta aptauja par to, kā cilvēki uztver datortehnikas dizaina aspektus. Pētījuma jautājums: kāda…
Funkcionalitātes paplašināšanas iespējas e-studiju sistēmā Moodle
2017
E-studiju sistēma Moodle apskatīta no funkcionalitātes paplašināšanas viedokļa. Pētījuma nolūks – piedāvāt risinājumu, kas balstīts uz Moodle tehniskajām iespējām un kas varētu tikt izmantots Latvijas Universitātes Datorikas fakultātes pirmā kursa studentu atbiruma problēmas risināšanā. Izpētīti Moodle testu jautājumu veidi un jaunu jautājumu veidu izveides iespējas. Izveidots Moodle spraudnis – jauns jautājumu veids, kam atbilde iesniedzama kā viens vai vairāki skaitļu intervāli. Izveidots Moodle tests, izmantojot gan esošos jautājumu veidus, gan jauno veidu un iekļaujot tajā dažādu tipu uzdevumus, kas paredzēti programmēšanas spēju novērtēšanai. Izveidotais tests dots izpildīšanai respond…
Simultaneous determination of olanzapine, clozapine and demethylated metabolites in serum by on-line column-switching high-performance liquid chromat…
2001
An automated method for simultaneous routine quantification of the antipsychotic drugs clozapine, olanzapine and their demethylated metabolites is described. The method included adsorption on a cyanopropyl (CPS) coated clean-up column (10 microm; 10 x 2.0 mm I.D.), washing off interfering serum constituents to waste, and separation on C18 ODS Hypersil reversed phase material (5 microm; 250 x 4.6 mm I.D.) using acetonitrile-water-tetramethylethylenediamine (37:62.6:0.4, v/v/v) adjusted to pH 6.5 with concentrated acetic acid. UV-detection was performed at 254 nm. The limit of quantification was 10-20 ng/ml. Relative day to day standard variations ranged between 4.5 and 13.5%. The method is s…
Automated analysis of quetiapine and other antipsychotic drugs in human blood by high performance-liquid chromatography with column-switching and spe…
2004
Abstract An automated HPLC method with column switching is described for the determination of quetiapine, clozapine, perazine, olanzapine and metabolites in blood serum. After clean-up on silica C8 material (20 μm particle size) drugs were separated on ODS Hypersil C18 material (5 μm; column size 250 mm × 4.6 mm i.d.) within 25 min and quantified by ultraviolet (UV) detection at 254 nm. The limit of quantification ranged between 10 and 50 ng/ml. At therapeutic concentrations of the drugs, the inter-assay reproducibility was below 10%. Analyses of drug concentrations in serum of 75–295 patients treated with therapeutic doses of the antipsychotic drugs revealed mean ± S.D. steady state concen…
Assessing drug-drug interactions through therapeutic drug monitoring when administering oral second-generation antipsychotics.
2016
Second-generation antipsychotics (SGAs) are frequently co-prescribed with drug metabolic inducers and inhibitors. SGA pharmacokinetic drug-drug interactions (DDIs) with inducers and inhibitors have not received enough attention in the literature but can be studied in by using therapeutic drug monitoring (TDM).The limited information available on oral SGA pharmacokinetic DDIs is reviewed. A systematic literature search on the available oral SGA TDM studies is completed. By integrating TDM studies with the information on in vitro metabolism studies, case report/series and prospective studies, a table is provided to manage average SGA patients taking inducers or inhibitors by using TDM and/or …