Search results for "tolerance"
showing 10 items of 956 documents
Adaptation and ecological speciation in seasonally varying environments at high latitudes: Drosophila virilis group
2022
Living in high latitudes and altitudes sets specific requirements on species’ ability to forecast seasonal changes and to respond to them in an appropriate way. Adaptation into diverse environmental conditions can also lead to ecological speciation through habitat isolation or by inducing changes in traits that influence assortative mating. In this review, we explain how the unique time-measuring systems of Drosophila virilis group species have enabled the species to occupy high latitudes and how the traits involved in species reproduction and survival exhibit strong linkage with latitudinally varying photoperiodic and climatic conditions. We also describe variation in reproductive barriers…
Learning to be a psychostimulants addict with self-regulation therapy
2018
This article presents the results of a single-case experiment of alternative treatments in which a participant applied the Self-Regulation Therapy (SRT) to reproduce the effects of a stimulant drug, methylphenidate, and a sedative, alcohol. The SRT is a learning procedure based on classic conditioning and suggestion that reproduces the effect of drugs by remembering the effects they have. The participant reproduced the effects of both drugs during ten sessions held on 5 consecutive days. To record effects, adjective scales were used that measured Drug effect, High, Rush, Energy, Tension and the General Factor of Personality (GFP). The results indicated that the participant was capable of in…
Residents'corner April 2014. Editorial: what's new this month?
2014
In this issue of the European Journal of Dermatology, Bircher et al.[1] revisit tolerance induction in drug hypersensitivity reactions, which is a controversial issue, particularly in delayed hypersensitivity reactions. Drug hypersensitivity may present as a mild, moderate or severe life-threatening reaction, becoming a problem for many patients when the offending drug is essential (and even irreplaceable).Determining which drug is responsible for the reaction may be challenging, especially in multiple [...]
Dynamic scheduling of periodic skippable tasks in an overloaded real-time system
2008
International audience; The need for supporting dynamic real-time environments where changes in workloads may occur requires a scheduling framework that explicitly addresses overload conditions, allows the system to achieve graceful degradation and supports a mechanism capable of determining the load to be shed from the system to handle the overload. In applications ranging from video reception to air-craft control, tasks enter periodically and have response time constraints, but missing a deadline is acceptable, provided most deadlines are met. Such tasks are said to be occasionally skippable and have an assigned skip parameter. We look at the problem of uniprocessor scheduling of skippabl…
Social class and university graduates’ overqualification: testing two mediated relationships
2018
[EN] University graduates’ overqualification (i.e., having more education, qualification and/or skills than one’s job requires) has important negative consequences. However, much less is known about its antecedents. This represents an important gap in the literature. In order to fill this gap, the goal of this study is to test a mediational model on the antecedents of university graduates’ overqualification (OQ). We posit that social class is negatively related to OQ through two mediational links: a) via social capital, and b) via social capital and tolerance towards OQ. The results obtained in a sample of 144 university graduates provided support for the second mediational link, so that so…
The Integration of Young Third-country Nationals into Educational Setting of Latvia
2015
<p>The integration of children of Third-country nationals into the society and labour market is one of the hot issues in Latvian education, therefore it is important to summarize and spread the professional experience of teachers working with these children.<br />The education is the main tool to turn them into creative and successful members of Latvian society. In other words, migration can be useful to both migrants and the host country.<br />There is an extremely high demand for specialists capable of working with migrants' children of different ethnicities, mother tongues, cultural backgrounds as well as knowledge levels that may be challenging because of a mismatch of…
Knowing is half the battle: Seasonal forecasts, adaptive cropping systems, and the mediating role of private markets in Zambia
2019
Abstract This paper examines how smallholders living in regions where a drought is forecasted adapt their farm practices in response to receiving seasonal forecast information. The article draws on a unique longitudinal dataset in Zambia, which collected information from farm households before and after a significant drought caused by the 2015/2016 El-Nino Southern Oscillation. It finds that farmers residing in areas forecasted to be drought-affected and receiving seasonal forecast information are significantly more likely to integrate drought tolerant crops into their cropping systems compared to similar households not receiving this information. Moreover, the probability that a farmer imp…
Microglial activation milieu controls regulatory T cell responses.
2013
Abstract Although mechanisms leading to brain-specific inflammation and T cell activation have been widely investigated, regulatory mechanisms of local innate immune cells in the brain are only poorly understood. In this study, to our knowledge we show for the first time that MHC class II+CD40dimCD86dimIL-10+ microglia are potent inducers of Ag-specific CD4+Foxp3+ regulatory T cells (Tregs) in vitro. Microglia differentially regulated MHC class II expression, costimulatory molecules, and IL-10 depending on the amount of IFN-γ challenge and Ag dose, promoting either effector T cell or Treg induction. Microglia-induced Tregs were functionally active in vitro by inhibiting Ag-specific prolifer…
Dendritic Cells Ameliorate Autoimmunity in the CNS by Controlling the Homeostasis of PD-1 Receptor+ Regulatory T Cells
2012
SummaryMature dendritic cells (DCs) are established as unrivaled antigen-presenting cells (APCs) in the initiation of immune responses, whereas steady-state DCs induce peripheral T cell tolerance. Using various genetic approaches, we depleted CD11c+ DCs in mice and induced autoimmune CNS inflammation. Unexpectedly, mice lacking DCs developed aggravated disease compared to control mice. Furthermore, when we engineered DCs to present a CNS-associated autoantigen in an induced manner, we found robust tolerance that prevented disease, which coincided with an upregulation of the PD-1 receptor on antigen-specific T cells. Additionally, we showed that PD-1 was necessary for DC-mediated induction o…
Protection from experimental allergic encephalomyelitis by application of a bacterial superantigen
1992
Certain bacterial and viral T cell stimulating proteins ('superantigens') are known to be very potent activators of T cells with certain V beta receptors. When applied in vivo these molecules induce anergy in those T cells responding to them. In this study we have investigated the influence of staphylococcal enterotoxins (SE) on myelin basic protein (MBP)-specific T cells in Lewis rats. As MBP-specific T cells in rats belong exclusively to the V beta 8.2+ CD4+ subset, the induction of experimental allergic encephalomyelitis (EAE) allows for an estimation of the functional state of the respective V beta-bearing T cells after enterotoxin-induced activation. In vitro, various MBP-specific T ce…