Search results for "topos"
showing 10 items of 153 documents
LA CONSULTA NEGA L'ABBRACCIO VIRTUALE FRA FIGLI MINORI E DETENUTI AL 41-BIS ORD. PENIT., RIDIMENSIONANDO I DANNI SIMBIOTICI ORIGINATI DAL CARCERE
2021
La Consulta trascura la duplice lesione causata dal divieto di colloqui da remoto con i figli minori, imposto in tempi di COVID a coloro che sono soggetti al regime dell’art. 41 bis ord. penit. La lotta alla criminalità organizzata prevale in base a ragioni formali e procedurali sui “danni simbiotici” ai familiari causati dalla detenzione.
Unraveling the extracellular matrix-tumor cell interactions to aid better targeted therapies for neuroblastoma
2021
Treatment in children with high-risk neuroblastoma remains largely unsuccessful due to the development of metastases and drug resistance. The biological complexity of these tumors and their microenvironment represent one of the many challenges to face. Matrix glycoproteins such as vitronectin act as bridge elements between extracellular matrix and tumor cells and can promote tumor cell spreading. In this study, we established through a clinical cohort and preclinical models that the interaction of vitronectin and its ligands, such as αv integrins, are related to the stiffness of the extracellular matrix in high-risk neuroblastoma. These marked alterations found in the matrix led us to speci…
Categories, Musical Instruments, and Drawings: A Unification Dream
2019
The mathematical formalism of category theory allows to investigate musical structures at both low and high levels, performance practice (with musical gestures) and music analysis. Mathematical formalism can also be used to connect music with other disciplines such as visual arts. In our analysis, we extend former studies on category theory applied to musical gestures, including musical instruments and playing techniques. Some basic concepts of categories may help navigate within the complexity of several branches of contemporary music research, giving it a unitarian character. Such a 'unification dream,' that we can call 'cARTegory theory,' also includes metaphorical references to topos th…
Cobre para los muertos. Estudio arqueométrico del material metálico procedente del monumento megalítico prehistórico de Castillejo del Bonete (Terrin…
2014
Castillejo del Bonete es una cueva que fue utilizada y adaptada como monumento funerario durante la Prehistoria reciente. Abundantes piezas metálicas en óptimo estado de conservación se han recuperado de los túmulos construidos encima de la cueva, tanto en el interior de tumbas como fuera de ellas. El objetivo de este trabajo es presentar la colección metálica del yacimiento recuperada hasta finales de 2012. También el estudio arqueometalúrgico de varias de las piezas y una interpretación del conjunto en relación a su ámbito cultural y territorial. La investigación además incorpora datos inéditos de El Acequión, Albacete, para proporcionar una perspectiva comparativa sobre la procedencia de…
Alterations of DNA Repair in Melanoma Cell Lines Resistant to Cisplatin, Fotemustine, or Etoposide
2000
Resistance to chemotherapy is a common phenomenon in malignant melanoma. In order to assess the role of altered DNA repair in chemoresistant melanoma, we investigated different DNA repair pathways in one parental human melanoma line (MeWo) and in sublines of MeWo selected in vitro for drug resistance against four commonly used drugs (cisplatin, fotemustine, etoposide, and vindesine). Host cell reactivation assays with the plasmid pRSVcat were used to assess processing of different DNA lesions. With ultraviolet-irradiated plasmids, no significant differences were found, indicating a normal (nucleotide excision) repair of DNA photoproducts. With singlet oxygen-treated plasmid, the fotemustine…
Lovastatin protects human endothelial cells from the genotoxic and cytotoxic effects of the anticancer drugs doxorubicin and etoposide
2006
Background and purpose: 3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) are frequently used lipid-lowering drugs. Moreover, they exert pleiotropic effects on cellular stress responses and death. Here, we analysed whether lovastatin affects the sensitivity of primary human endothelial cells (HUVEC) to the anticancer drug doxorubicin. Experimental approach: We investigated whether pretreatment of HUVEC with low dose of lovastatin influences the cellular sensitivity to doxorubicin. To this end, cell viability, proliferation and apoptosis as well as DNA damage-triggered stress response were analysed. Key results: Lovastatin reduced the cytotoxic potency of doxorub…
The bacterial cytolethal distending toxin (CDT) triggers a G2 cell cycle checkpoint in mammalian cells without preliminary induction of DNA strand br…
1999
The bacterial cytolethal distending toxin (CDT) was previously shown to arrest the tumor-derived HeLa cell line in the G2-phase of the cell cycle through inactivation of CDK1, a cyclin-dependent kinase whose state of activation determines entry into mitosis. We have analysed the effects induced in HeLa cells by CDT, in comparison to those induced by etoposide, a prototype anti-tumoral agent that triggers a G2 cell cycle checkpoint by inducing DNA damage. Both CDT and etoposide inhibit cell proliferation and induces the formation of enlarged mononucleated cells blocked in G2. In both cases, CDK1 from arrested cells could be re-activated both in vitro by dephosphorylation by recombinant Cdc25…
Mandible histology in Metoposaurus krasiejowensis (Temnospondyli, Stereospondyli) from the Upper Triassic of Poland
2021
Recent studies that have systematically augmented our knowledge of dermal bones of the Late Triassic temnospondyl amphibian Metoposaurus krasiejowensis have mostly focused on shoulder girdle elements and the skull. So far, histological data on the mandible are still scant. For the present study, two mandibles have been examined, using 50 standard thin sections. Dermal bones of the mandible reveal a uniform diploë structure, with the external cortex consisting of moderately vascularised, parallel-fibred bone, as well as a distinct alternation of thick zones and thinner annuli. Dense bundles of well-mineralised Sharpey’s fibres are seen in the external cortex over the entire length of the man…
Some remarks on the category SET(L), part III
2004
This paper considers the category SET(L) of L-subsets of sets with a fixed basis L and is a continuation of our previous investigation of this category. Here we study its general properties (e.g., we derive that the category is a topological construct) as well as some of its special objects and morphisms.
Targeting BCL-2 family proteins to overcome drug resistance in non-small cell lung cancer.
2007
Cytotoxic chemotherapies are standard of care for patients suffering from advanced non-small cell lung cancer (NSCLC). However, objective responses are only achieved in 20% of cases and long-term survival is rarely observed. Clinically applied anticancer drugs exert at least some of their activities by inducing apoptosis. A critical step in apoptotic signal transduction is the permeabilization of the mitochondrial outer membrane (MOM), which is regulated by the BCL-2 family of proteins. Hence, therapeutic targeting of BCL-2 proteins is a promising approach to increase the drug-sensitivity of cancers. To this end we have assessed the impact of conditional expression of the proapoptotic multi…