Search results for "topos"
showing 10 items of 153 documents
Repaso a la evidencia isotópica sobre alimentación en la prehistoria valenciana durante el Mesolítico y el Neolítico
2016
Los análisis de isótopos estables son una herramienta fundamental a la hora de reconstruir la alimentación de poblaciones prehistóricas. Hasta hace poco este tipo de análisis no se había aplicado en nuestra tierra. Sin embargo, desde hace unos años el Este de la Península Ibérica se está convirtiendo en uno de los lugares del Mediterráneo donde se está realizando un mayor número de este tipo de estudios. Este artículo explica el potencial de los análisis isotópicos de carbono y nitrógeno sobre colágeno óseo para reconstruir las pautas alimentarias de poblaciones pasadas. También repasa todos los estudios publicados en tierras valencianas de cronología prehistórica publicados hasta la fecha,…
The CD95/CD95 ligand system is not the major effector in anticancer drug-mediated apoptosis.
1998
Many anticancer drugs are able to induce apoptosis in tumor cells but the mechanisms underlying this phenomenon are poorly understood. Some authors reported that the p53 tumor suppressor gene may be responsible for drug-induced apoptosis; however, chemotherapy-induced apoptosis can also be observed in p53 negative cells. Recently, doxorubicin (DXR) was reported to induce CD95L expression to mediate apoptosis through the CD95/CD95L system. Thus, an impairment of such a system may be involved in drug resistance. We evaluated the in vitro antitumor activity of several cytotoxic drugs on two human p53-negative T-cell lymphoma cell lines, the HUT78-B1 CD95L-resistant cell line and the HUT78 pare…
Représentation et langage de la fuite dans "Pauliska" de Révéroni Saint-Cyr
2002
Il contributo si propone di esaminare il tema della fuga nel romanzo "Pauliska" di Révéroni Saint-Cyr. Il tema, in effetti, costituisce in questo romanzo un vero e proprio topos che consente alla trama di dipanarsi e di trovare occasione per fare ripartire la dieresi.
Crustal controls on light noble gas isotope variability along the andean volcanic arc
2021
This study combines new noble gas data from fluid inclusions in minerals from Sabancaya, Ubinas, and El Misti (CVZ, Peru) and Villarica (South Chile, SVZ) with a revised noble gas compilation in the Andes, to identify systematic along arc variations in helium isotope compositions. We find 3He/4He ratios varying from 8.8 RA (Colombia) to 7.4 RA (Ecuador) within the NVZ, and only as high as 6.4 RA in the CVZ (RA is the atmospheric 3He/4He ratio of 1.39 × 10–6). These distinct isotope compositions cannot be explained by variable radiogenic 4He production via slab fluid transport of U and Th in the mantle wedge, since both NVZ and CVZ share similar slab sediment inputs (Th/La ≈ 0.08–0.13). Inst…
Leitbilder im Recht: Grenzen der Ordnung – Chancen der Unordnung
2018
„Guiding principles“ as topoi in German juridical discourse are mainly analyzed with regard to their relation to familiar dogmatic and methodological categories. This article suggests engaging with a deconstructing, psychoanalysis-inspired approach to the guiding principles of legal discourse.
Synthesis and induction of G0–G1 phase arrest with apoptosis of 3,5-dimethyl-6-phenyl-8-(trifluoromethyl)-5,6-dihydropyrazolo[3,4-f][1,2,3,5]tetrazep…
2007
The multistep synthesis of 3,5-dimethyl-6-phenyl-8-(trifluoromethyl)-5,6-dihydropyrazolo[3,4-f][1,2,3,5]tetrazepin-4(3H)-one 15 has been carried out. The compound showed antiproliferative and apoptotic effects against K562, K562-R (imatinib mesilate resistant), HL60 and multidrug resistant (MDR) HL60 cell lines. Compound 15 showed a pro-apoptotic activity against HL60 and K562 resistant cell lines markedly higher than etoposide and busulfan, respectively. Flow cytometry studies carried out on K562 cells allowed to establish that 15 induces G0-G1 phase arrest followed by apoptosis.
A Modern-Day Diary : Notes for Future Humans
2021
Abstract Time and being can be seen as a space. A modern-day diary is a way of exploring that space or state of being. Outlining and shaping it requires word, image and imagination. The question is framed cultural-philosophically, and the mode of writing is poetic essayism. Otherwise, the creative untangling and differentiation of the poetics of lived space is not possible. After all, the goal is to combine science and art and weave them into the same reflective fabric. The essential aspects include thoughts about the fullness and filling of something, about its fulfilment. Then the present moment is not seen as marking a boundary in just one direction: it is not just an endpoint of the pas…
[Apoptosis of human leukemic cells induced by topoisomerase I and II inhibitors].
1996
International audience; Comparison between five human leukemic lines (BV173, HL60, U937, K562, KCL22) suggest that the main determinant of their sensitivity to topoisomerase I (camptothecin) and II (VP-16) inhibitors is their ability to regulate cell cycle progression in response to specific DNA damage, then to die through apoptosis: the more the cells inhibit cell cycle progression, the less sensitive they are. The final pathway of apoptosis induction involves a cytoplasmic signal, active at neutral pH, needing magnesium, sensitive to various protease inhibitors and activated directly by staurosporine. Modulators of intracellular signaling (calcium chelators, calmodulin inhibitors, PKC mod…
Use of CDC2 from etoposide-treated cells as substrate to assay CDC25 phosphatase activity
1999
International audience; Cyclin-dependent kinases (CDKs) regulate the key transition of the cell cycle in all organisms. In response to Etoposide (VP-16) induced DNA damage, cells undergo a G2-phase arrest resulting in the accumulation of inactive CDK1 (CDC2) kinase complexes. Here we report that upon Etoposide treatment CDC2 is phosphorylated on tyrosine 15 and is dephosphorylated and activated in vitro by recombinant CDC25 phosphatase. We also show that inactive CDC2 kinase from Etoposide-treated cells can be used as a substrate in a sensitive two-step assay of CDC25 phosphatase. This assay, which is very simple to set-up, is based on the monitoring of CDC2 kinase activity after CDC25-depe…
Osteonecrosis detected by whole body magnetic resonance in patients with Hodgkin Lymphoma treated by BEACOPP
2016
Objectives: The purpose of our retrospective review of prospectively acquired Whole Body Magnetic Resonance (WB-MRI) scans was to assess the incidence of osteonecrosis in patients who received different chemotherapies. Methods: We evaluated the WB-MRI scans performed on 42 patients with Hodgkin Lymphoma treated by three chemotherapy regimens (6ABVD, 2ABVD + 4BEACOPP, 2ABVD + 8BEACOPP), excluding patients with the main risk factors for osteonecrosis. Results: Six out of seven patients (86 %) who received eight BEACOPP and one out of five patients (20 %) treated by four BEACOPP presented osteonecrosis, with a statistically significant difference of frequency between the two groups of patients…