Search results for "trace"

showing 10 items of 3218 documents

Binding mode analysis of ABCA7 for the prediction of novel Alzheimer's disease therapeutics

2021

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ATP Adenosine-triphosphateNBD nucleotide binding domainGSH reduced glutathionePolypharmacologyAlzheimer’s disease (AD)ATP-binding cassette transporterHTS high-throughput screeningBiochemistryABCA7Structural BiologyPLIF protein ligand interactionMSD membrane spanning domainPDB protein data bankTM transmembrane helixABC ATP-binding cassetteMultitarget modulation (PANABC)RMSD root mean square distanceABC transporter (ABCA1 ABCA4 ABCA7)Computer Science ApplicationsMOE Molecular Operating EnvironmentPharmacophoreSNP single-nucleotide polymorphismBiotechnologyResearch ArticleBBB blood-brain barrierBiophysicsDrug designComputational biologyBiologyAD Alzheimer’s diseasePET positron emission tomographyIC intracellular helixAPP amyloid precursor proteincryo-EM cryogenic-electron microscopyGeneticsHomology modelingBinding siteRational drug design and developmentComputingMethodologies_COMPUTERGRAPHICSNBD-cholesterol 7-nitro-2-13-benzoxadiazol-4-yl-cholesterolTransporterPSO particle swarm optimizationPET tracer (PETABC)ECD extracellular domainR-domain/region regulatory domain/regionABCA1biology.proteinEH extracellular helixTP248.13-248.65BODIPY-cholesterol 44-difluoro-4-bora-3a4a-diaza-s-indacene-cholesterolComputational and Structural Biotechnology Journal
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P2Y-mediated contractile responses in the longitudinal muscle of mouse distal colon: distinct signaling pathways

2008

ATPMouse distal colonP2Y purinoreceptorIntracellular calcium storeMuscular contractionSettore BIO/09 - Fisiologia
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Activation of P2Y receptors by ATP and by its analogue, ADPbetaS, triggers two calcium signal pathways in the longitudinal muscle of mouse distal col…

2008

Our previous research showed that ATP and adenosine 5'-O-2-thiodiphosphate (ADPbetaS) induce contractile effects in the longitudinal muscle of mouse distal colon via activation of P2Y receptors which are not P2Y(1) or P2Y(12) subtypes. This study investigated the nature of the P2Y receptor subtype(s) and the mechanisms leading to the intracellular calcium concentration increase necessary to trigger muscular contraction. Motor responses of mouse colonic longitudinal muscle to P2Y receptor agonists were examined in vitro as changes in isometric tension. ATP or ADPbetaS induced muscular contraction, which was not affected by P2Y(11) or P2Y(13) selective antagonists. Calcium-free solution or th…

ATPP2Y purinoreceptorIntracellular calcium storeMuscular contractionSettore BIO/09 - Fisiologia
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Agonist-specific Ca2+ signaling at P2Y receptors

2008

ATPP2Y purinoreceptorIntracellular calcium storeMuscular contractionSettore BIO/09 - Fisiologia
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Giant hepatocellular adenoma as cause of severe abdominal pain: a case report

2007

Abstract The authors describe the case of a large hepatocellular adenoma diagnosed in a 30-year old woman who came to us complaining of acute pain in the upper abdominal quadrants. The patient had been taking an oral contraceptive pill for the last ten years. We present the clinical features, the diagnostic work-up and the treatment prescribed.

Abdominal painPathologyoral contraceptive agent EMTREE medical terms: abdominal painanamnesilcsh:Medicinecomputer assisted tomographyaspartate aminotransferaseSurgical oncologynuclear magnetic resonance imagingMedicine(all)oral contraceptionadultarticleGeneral MedicineAbdominal quadrantsfemalepriority journalhistopathologycontrast enhancementdisease severitymedicine.symptomEMTREE drug terms: alanine aminotransferasemedicine.medical_specialtyOral contraceptive pillcontrast mediummedicinediffusion weighted imagingcase reportfollow uphumanAcute painliver biopsydrug useliver lobectomybusiness.industryGeneral surgeryPublic healthlcsh:RechographyHepatocellular adenomaliver angiographymedicine.diseasetumor bleedinghuman tissueclinical featurenausea and vomitingbusinessaspartate aminotransferase blood levelliver adenomaalanine aminotransferase blood level
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Abdominal wall reconstruction by a regionally distinct biocomposite of extracellular matrix digest and a biodegradable elastomer.

2013

Current extracellular matrix (ECM) derived scaffolds offer promising regenerative responses in many settings, however in some applications there may be a desire for more robust and long lasting mechanical properties. A biohybrid composite material that offers both strength and bioactivity for optimal healing towards native tissue behavior may offer a solution to this problem. A regionally distinct biocomposite scaffold composed of a biodegradable elastomer (poly(ester urethane)urea) and porcine dermal ECM gel was generated to meet this need by a concurrent polymer electrospinning/ECM gel electrospraying technique where the electrosprayed component was varied temporally during the processing…

Abdominal wall reconstructionScaffoldPolyurethaneElectrospinningBiodegradableElastomerExtracellular matrix
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Ricerche in tema di società questuarie

2019

Intorno al regime delle società di tipo questuario – riconducibili agli schemi teorici della societas universorum quae ex quaestu veniunt – e delle società unius alicuius negotiationis e unius rei, si profusero gli sforzi interpretativi dei giuristi romani, fin dalla fine dell’età repubblicana. La monografia scientifica ripercorre le tracce della individuazione della nozione stessa di quaestus (guadagno), con particolare riferimento alla inclusione al suo interno delle donazioni cd. remuneratorie; ancora, ricostruisce il dibattito giurisprudenziale sorto intorno alla questione se i soci – nella determinazione delle quote – dovessero rispettare una proporzione rispetto ai conferimenti, con u…

About the regulations of the societas quaestus - referable to the societas universorum quae ex quaestu veniunt and to the societas unius alicuius negotiationis and unius rei - the interpretative efforts of the Roman jurists were given profusely since the end of the republican age. The scientific monograph puts itself on the traces of identifying the notion of quaestus (gain) with particular reference to the inclusion within it of the so-called remuneration gifts. Furthermore it reconstructs the jurisprudential debate that aroses around the question of whether the socii - in the determination of the shares - had to respect a proportion with the contributions and in this sense with an attempt to explain the existing contrast between a passage from the Digest and one of the Iustiniani Institutiones. Moreover always with specific reference to the societas quaestus the monograph investigates the setting-up of the intempestiva renuntiatio supporting its origin out of the contrast between Proculiani and Sabiniani so far postulated in doctrine. Finally the book closes with a chapter dedicated to the genesis of the term egestas which appears in a fragment of Modestinus (D. 17.2.4.1) dedicated to the causes of dissolution of the societas consensu contractaSettore IUS/18 - Diritto Romano E Diritti Dell'Antichita'
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Investigation of the Electrophoretic Mobility of the Actinides Th, U, Np, Pu, and Am in Different Oxidation States.

2019

The electrophoretic mobilities (μe) of the actinides Th and U-Am in different oxidation states (prepared in 1 M HCl and 1 M HClO4) have been determined by capillary electrophoresis (CE)-inductively coupled plasma mass spectrometry (ICPMS) using 1 M acetic acid as the background electrolyte, which has proven to provide an excellent setup for trace analysis at environmentally relevant concentrations (1 × 10-9 M). The values are independent of the respective acid solution. The μe of the Pu oxidation states +III to +VI have been measured. They agree with both the available literature data and the redox-stable analogues (Eu(III), Th(IV), Np(V), U(VI)) that have also been investigated. The trend …

Acetic acidchemistry.chemical_compoundElectrophoresisCapillary electrophoresischemistryAnalytical chemistryTrace analysisElectrophoretic mobilitiesElectrolyteActinideMass spectrometryAnalytical ChemistryAnalytical chemistry
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MANUALE TECNICO APPLICATIVO PROGETTO ASASI

2014

Aceto nutraceutica polifenoli
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Systematic Analysis of Combined Thrombolysis Using Ultrasound and Different Fibrinolytic Drugs in an in Vitro Clot Model of Intracerebral Hemorrhage.

2021

Adequate removal of blood clots by minimally invasive surgery seems to correlate with a better clinical outcome in patients with intracerebral hemorrhages (ICHs). Moreover, neurotoxic effects of recombinant tissue plasminogen activator have been reported. The aim of this study was to improve fibrinolysis using an intra-clot ultrasound application with tenecteplase and urokinase in our established ICH clot model. One hundred thirty clots were produced from 25 or 50 mL of human blood, incubated for different periods and equipped with drainage, through which an ultrasound catheter was placed in 65 treatment clots for 1 h, randomly allocated into three groups: administration of ultrasound, admi…

Acoustics and UltrasonicsMechanical Thrombolysismedicine.medical_treatmentUltrasonic TherapyBiophysicsTenecteplase030204 cardiovascular system & hematologyIn Vitro Techniques03 medical and health sciences0302 clinical medicineFibrinolytic AgentsFibrinolysismedicineHumansRadiology Nuclear Medicine and imagingThrombolytic TherapyCerebral HemorrhageIntracerebral hemorrhageUrokinaseRadiological and Ultrasound Technologybusiness.industryUltrasoundThrombosisThrombolysismedicine.diseaseCombined Modality TherapyUrokinase-Type Plasminogen ActivatorIn vitroCatheterAnesthesiaTenecteplasebusiness030217 neurology & neurosurgerymedicine.drugUltrasound in medicinebiology
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