Search results for "trace"
showing 10 items of 3218 documents
Hafnium-Neodymium isotope, trace element and U-Pb zircon age constraints on the petrogenesis of the 3.44–3.46 Ga Dwalile greenstone remnant, Ancient …
2020
Abstract The geodynamic setting of the 3.44–3.46 Ga Dwalile greenstone remnant (DGR) of the Ancient Gneiss Complex (Swaziland) and its relationship to other Greenstone belts of similar age is investigated in this contribution. We present Hf-Nd isotope, major and trace element data for komatiites, komatiitic basalts, basalts, basaltic andesites as well as felsic volcanic and sedimentary rocks, all metamorphosed at amphibolite-facies grade. Major and trace element compositions of metabasalts and metakomatiites indicate crustal contamination. The best-preserved samples yield 176Lu-176Hf and 147Sm-143Nd isochron ages of ca. 3500 and 3460 Ma, respectively, in line with U-Pb zircon ages of interl…
Coupled evolution of back-arc and island arc-like mafic crust in the late-Neoproterozoic Agardagh Tes-Chem ophiolite, Central Asia: evidence from tra…
2002
We report major-element, trace-element and isotopic data of volcanic rocks from the late-Neoproterozoic (570 Ma) Agardagh Tes-Chem ophiolite in Central Asia, south-west of Lake Baikal (50.5°N, 95°E). The majority of samples are high-alumina basalts and basaltic andesites having island-arc affinities. They were derived from an evolved parental magma (Mg#≥0.60, Cr~180 ppm, Ni~95 ppm) by predominantly clinopyroxene fractionation. The parental magma developed from a primary mantle melt by fractionation of about 12% of an olivine+spinel assemblage. The island-arc rocks have high abundances of incompatible trace elements (light rare-earth element abundances up to 100 times chondritic, chondrite-n…
Atmospheric sources and sinks of volcanogenic elements in a basaltic volcano (Etna, Italy)
2011
Abstract This study reports on the first quantitative assessment of the geochemical cycling of volcanogenic elements, from their atmospheric release to their deposition back to the ground. Etna’s emissions and atmospheric depositions were characterised for more than 2 years, providing data on major and trace element abundance in both volcanic aerosols and bulk depositions. Volcanic aerosols were collected from 2004 to 2007, at the summit vents by conventional filtration techniques. Precipitation was collected, from 2006 to 2007, in five rain gauges, at various altitudes around the summit craters. Analytical results for volcanic aerosols showed that the dominant anions were S, Cl, and F, and…
Mercury concentration, speciation and budget in volcanic aquifers: Italy and Guadeloupe (Lesser Antilles)
2009
Abstract Quantifying the contribution of volcanism to global mercury (Hg) emissions is important to understand the pathways and the mechanisms of Hg cycling through the Earth's geochemical reservoirs and to assess its environmental impacts. While previous studies have suggested that degassing volcanoes might contribute importantly to the atmospheric budget of mercury, little is known about the amount and behaviour of Hg in volcanic aquifers. Here we report on detailed investigations of both the content and the speciation of mercury in aquifers of active volcanoes in Italy and Guadeloupe Island (Lesser Antilles). In the studied groundwaters, total Hg (THg) concentrations range from 10 to 500…
Changes in soil chemical properties as affected by pyrogenic organic matter amendment with different intensity and frequency
2017
Pyrogenic organic matter (PyOM) has long been used as a soil amendment to improve soil physicochemical properties. However, few studies simultaneously investigated both intensities and frequencies of PyOM addition on soil chemical properties of soil base cations, soil pH buffering capacity (pHBC), and plant available micronutrients. In the main food production area of lower Liaohe River Plain in Northeast China, a field manipulation of PyOM addition was initiated in 2013 to examine how the intensities (0, 1%, 3%, and 5% of 0–20 cm soil mass) and frequencies (3% of soil mass applied once versus yearly for 3 years) of PyOM amendment affected soil chemical properties. Higher intensity of PyOM …
Goodpasture Antigen-binding Protein (GPBP) Directs Myofibril Formation
2011
Goodpasture antigen-binding protein-1 (GPBP-1) is an exportable non-conventional Ser/Thr kinase that regulates glomerular basement membrane collagen organization. Here we provide evidence that GPBP-1 accumulates in the cytoplasm of differentiating mouse myoblasts prior to myosin synthesis. Myoblasts deficient in GPBP-1 display defective myofibril formation, whereas myofibrils assemble with enhanced efficiency in those overexpressing GPBP-1. We also show that GPBP-1 targets the previously unidentified GIP130 (GPBP-interacting protein of 130 kDa), which binds to myosin and promotes its myofibrillar assembly. This report reveals that GPBP-1 directs myofibril formation, an observation that expa…
Elastin Cables Define the Axial Connective Tissue System in the Murine Lung
2015
The axial connective tissue system is a fiber continuum of the lung that maintains alveolar surface area during changes in lung volume. Although the molecular anatomy of the axial system remains undefined, the fiber continuum of the lung is central to contemporary models of lung micromechanics and alveolar regeneration. To provide a detailed molecular structure of the axial connective tissue system, we examined the extracellular matrix of murine lungs. The lungs were decellularized using a 24 hr detergent treatment protocol. Systematic evaluation of the decellularized lungs demonstrated no residual cellular debris; morphometry demonstrated a mean 39 ± 7% reduction in lung dimensions. Scanni…
Strategies for Survival of Extracellular Pathogens
2002
Publisher Summary This chapter highlights a simple listing of microbial factors that may contribute to extracellular survival. In addition, it outlines principles and discusses prototypes for extracellular versus intracellular survival strategies. Strategies for extracellular survival can often be equated with pathogenicity mechanisms, and counteractive measures can therefore form the basis for prophylaxis or therapy of the respective infections. These aspects are aluded throughout the chapter, since they investigates how basic research into microbial virulence mechanisms can lead to advances in clinical medicine. Most bacteria that cause extracellular infections cannot afford to be engulfe…
GSK-3? Can Regulate the Sensitivity of MIA-PaCa-2 Pancreatic and MCF-7 Breast Cancer Cells to Chemotherapeutic Drugs, Targeted Therapeutics and Nutra…
2021
Glycogen synthase kinase-3 (GSK-3) is a regulator of signaling pathways. KRas is frequently mutated in pancreatic cancers. The growth of certain pancreatic cancers is KRas-dependent and can be suppressed by GSK-3 inhibitors, documenting a link between KRas and GSK-3. To further elucidate the roles of GSK-3β in drug-resistance, we transfected KRas-dependent MIA-PaCa-2 pancreatic cells with wild-type (WT) and kinase-dead (KD) forms of GSK-3β. Transfection of MIA-PaCa-2 cells with WT-GSK-3β increased their resistance to various chemotherapeutic drugs and certain small molecule inhibitors. Transfection of cells with KD-GSK-3β often increased therapeutic sensitivity. An exception was observed wi…
De novo design of protein kinase inhibitors by in silico identification of hinge region-binding fragments.
2013
Protein kinases constitute an attractive family of enzyme targets with high relevance to cell and disease biology. Small molecule inhibitors are powerful tools to dissect and elucidate the function of kinases in chemical biology research and to serve as potential starting points for drug discovery. However, the discovery and development of novel inhibitors remains challenging. Here, we describe a structure-based de novo design approach that generates novel, hinge-binding fragments that are synthetically feasible and can be elaborated to small molecule libraries. Starting from commercially available compounds, core fragments were extracted, filtered for pharmacophoric properties compatible w…