Search results for "trafficking"

Calpains promote α2β1 integrin turnover in nonrecycling integrin pathway

2012

A novel virus- and integrin clustering–specific pathway diverts integrin from its normal endo/exocytic traffic to a nonrecycling degradative endosomal route. Clustering of α2β1 integrin causes redistribution of the integrin to perinuclear endosomes, leading to enhanced integrin turnover promoted by calpains.

The endocytic trafficking pathway of oncogenic papillomaviruses

2019

Over the last two decades many host cell proteins have been described to be involved in the process of infectious entry of oncogenic human papillomaviruses (HPV). After initial binding and priming of the capsid, a sequence of events on the cell surface precedes the formation of the HPV entry platform. It has been shown that the virus-associated entry complex consists of membrane organizers, tetraspanins CD151 and CD63, and their associated partner proteins such as integrins, growth factor receptors, and the annexin A2 heterotetramer. Further recruitment of cytoplasmic factors such as the obscurin-like protein 1 and actin results in a non-canonical clathrin-independent endocytosis of the vir…

Analysis of intracellular FGF-2 trafficking in Sk-Hep1 cells.

2005

Vulnerabilità, consenso, responsabilità: alcuni casi di grave sfruttamento lavorativo e tratta delle donne migranti in Italia

2017

A partire dalla definizione di sfruttamento e dalla problematizzazione dell'idea di libertà contrattuale e di consenso, il contributo analizza alcuni casi di grave sfruttamento lavorativo e di tratta ai danni delle donne migranti nell'ambito del settore domestico e di quello agricolo. I dati e le interviste qualitative raccolte sul campo confermano quindi le premesse teoriche (e normative) che avevano ricostruito la vulnerabilità in termini di mancanza di alternative percorribili e la tratta come abuso della posizione di vulnerabilità così definita.

Lrp4, a Novel Receptor for Dickkopf 1 and Sclerostin, Is Expressed by Osteoblasts and Regulates Bone Growth and Turnover In Vivo

2009

Lrp4 is a multifunctional member of the low density lipoprotein-receptor gene family and a modulator of extracellular cell signaling pathways in development. For example, Lrp4 binds Wise, a secreted Wnt modulator and BMP antagonist. Lrp4 shares structural elements within the extracellular ligand binding domain with Lrp5 and Lrp6, two established Wnt co-receptors with important roles in osteogenesis. Sclerostin is a potent osteocyte secreted inhibitor of bone formation that directly binds Lrp5 and Lrp6 and modulates both BMP and Wnt signaling. The anti-osteogenic effect of sclerostin is thought to be mediated mainly by inhibition of Wnt signaling through Lrp5/6 within osteoblasts. Dickkopf1 …

Giustizia penale e tratta di esseri umani: i risvolti processuali della "vulnerabilità"

2017

Il contrasto dei fenomeni di tratta e di traffico di esseri umani mostra un processo di “contaminazione” fra normativa di tipo universale e regionale, caratterizzato dal rispetto dello standard di Duty of Due Diligence. Domina lo scenario italiano il concetto polifunzionale di “vulnerabilità”, direttamente trasfuso nella fattispecie sostanziale, recepito nel sistema processuale ed evidenziato da alcuni esiti giurisprudenziali. Esso, oltre a influenzare la determinazione del locus commissi delicti, gioca un ruolo di sicuro rilievo nel giustificare forme di anticipazione del contraddittorio e nel tratteggiare i contorni della prova dichiarativa “debole”. Ulteriori effetti la “vulnerabilità” e…

Human smuggling and human trafficking. A normative and criminological outline

2021

Human smuggling and human trafficking are, from a normative point of view, strictly separated but frequently, at a criminological level, they overlap in a tangled-up situation in which it is not easy to separate them. This gap could have serious consequences in the fight against the criminal phenomena. In this brief contribution, I will try to show the extent of this gap and its consequences. Firstly, I will focus on the normative approach on HS and HT. Secondly, I will give a brief criminal outline of the two phenomena. Finally, I will try to underline the inadequacy of the dominating normative point of view.

The dark side of the laws against human trafficking: the need for a new, not exclusively criminal approach in a global world perspective

2014

Human trafficking is a question cannot be solved by a mere criminal law point of view. The dark side of the law is that in reality instead of a punishment against criminals, we have increased the punishment of the irregular or clandestine migrants I.e. The real victims. On the contrary, we need a different loom providing for massive international cooperation and collaboration with the weak and developing countries; we also need to fight the irregular immigration not only with a narrow criminal law or statutory approach, but also in a multidisciplinary way using the instruments offered by private law and European and international law as for instance the consumer protection or competition la…

Human Siglec-10 can bind to vascular adhesion protein-1 and serves as its substrate

2009

AbstractLeukocytes migrate from the blood into areas of inflammation by interacting with various adhesion molecules on endothelial cells. Vascular adhesion protein-1 (VAP-1) is a glycoprotein expressed on inflamed endothelium where it plays a dual role: it is both an enzyme that oxidizes primary amines and an adhesin that is involved in leukocyte trafficking to sites of inflammation. Although VAP-1 was identified more than 15 years ago, the counterreceptor(s) for VAP-1 on leukocytes has remained unknown. Here we have identified Siglec-10 as a leukocyte ligand for VAP-1 using phage display screenings. The binding between Siglec-10 and VAP-1 was verified by different adhesion assays, and this…

Chemical profiling of the synthetic cannabinoid MDMB-CHMICA: Identification, assessment, and stability study of synthesis-related impurities in seize…

2019

In this work, the most discriminating synthesis-related impurities found in samples from seizures and controlled synthesis of the synthetic cannabinoid MDMB-CHMICA (methyl (S)-2-(1-(cyclohexylmethyl)-1H-indole-3-carboxamido)-3,3-dimethylbutanoate) were characterized. Based on 61 available powder samples of MDMB-CHMICA, 15 key-impurities were assessed, isolated in larger quantities via flash chromatography and structurally elucidated and characterized via high resolution mass spectrometry and nuclear magnetic resonance spectroscopy. Apart from verifying the relation of the impurities to the major component, the interpretation of their chemical structures with distinct structural elements pro…