Search results for "train"

Indications for ECMO: we need to look at the patient first

2021

Elusive active faults in a low strain rate region (Sicily, Italy): Hints from a multidisciplinary land-to-sea approach

2022

Low Strain Rate regions (LSRrs), i.e., areas undergoing tectonic deformation at rates of 1 mm/yr or less, often host important cities and highly vulnerable anthropogenic assets, and due to their subdued topography and relatively infrequent seismicity, are often considered low seismic hazard areas. Despite this, infrequent but high-magnitude earthquakes in such regions suggest that identifying active structures in the LSRr is one of the primary challenges for both the scientific community and modern societies. In such regions, one of the main issues in identifying active faults is the lack of valuable outcrop data due to erosional/sedimentation rates overwhelming the fault deformation, causi…

Musical training predicts cerebello-hippocampal coupling during music listening.

2018

Cerebello-hippocampal interactions occur during accurate spatiotemporal prediction of movements. In the context of music listening, differences in cerebello-hippocampal functional connectivity may result from differences in predictive listening accuracy. Using functional MRI, we studied differences in this network between 18 musicians and 18 nonmusicians while they listened to music. Musicians possess a predictive listening advantage over nonmusicians, facilitated by strengthened coupling between produced and heard sounds through lifelong musical experience. Thus, we hypothesized that musicians would exhibit greater functional connectivity than nonmusicians as a marker of accurate online pr…

Site-specific DBCO modification of DEC205 antibody for polymer conjugation

2018

The design of multifunctional polymer-based vectors, forming pDNA vaccines, offers great potential in cancer immune therapy. The transfection of dendritic immune cells (DCs) with tumour antigen-encoding pDNA leads to an activation of the immune system to combat tumour cells. In this work, we investigated the chemical attachment of DEC205 antibodies (aDEC205) as DC-targeting structures to polyplexes of P(Lys)-b-P(HPMA). The conjugation of a synthetic block copolymer and a biomacromolecule with various functionalities (aDEC205) requires bioorthogonal techniques to avoid side reactions. Click chemistry and in particular the strain-promoted alkyne-azide cycloaddition (SPAAC) can provide the req…

Action in Perception: Prominent Visuo-Motor Functional Symmetry in Musicians during Music Listening.

2015

Musical training leads to sensory and motor neuroplastic changes in the human brain. Motivated by findings on enlarged corpus callosum in musicians and asymmetric somatomotor representation in string players, we investigated the relationship between musical training, callosal anatomy, and interhemispheric functional symmetry during music listening. Functional symmetry was increased in musicians compared to nonmusicians, and in keyboardists compared to string players. This increased functional symmetry was prominent in visual and motor brain networks. Callosal size did not significantly differ between groups except for the posterior callosum in musicians compared to nonmusicians. We conclude…

Formulations and exact algorithms for the distance-constrained generalized directed rural postman problem

2017

[EN] The generalized directed rural postman problem is an arc routing problem with many interesting real-life applications, such as routing for meter reading. In this application, a vehicle with a receiver travels through a series of neighborhoods. If the vehicle gets closer than a certain distance to a meter, the receiver is able to record the gas, water, or electricity consumption. Therefore, the vehicle does not need to traverse every street, but only a few, to get close enough to each meter. We study an extension of this problem in which a fleet of vehicles is available. Given the characteristics of the mentioned application, the vehicles have no capacities but there is a maximum distan…

Effects of elastic-based exercise interventions on oxidative stress, bone health, body composition, neuromuscular strength and physical function in o…

2021

Antecedentes El envejecimiento de la población mundial es reconocido por la Organización Mundial de la Salud (OMS) como un problema principal debido a las discapacidades y comorbilidades relacionadas con este proceso, siendo las mujeres el género más afectado. Debido al deterioro y las consecuencias asociadas al envejecimiento, la actividad física y el ejercicio han demostrado ser estrategias eficaces para reducir el impacto del envejecimiento. Sin embargo, todavía se desconoce qué tipo de programa de entrenamiento podría ser el más eficaz para revertir los cambios deletéreos relacionados con la edad en mujeres mayores. En este sentido, el tipo de intensidad del entrenamiento y la modalidad…

Stress-strain analysis of specimens subjected to tensile loading during moisture uptake

2015

Abstract: A robust and efficient numerical method for the calculation of the internal stress state that develops within structures subjected to mechanical and steady state or transient hygroscopic loading conditions, has been developed. The method encompasses a layer by layer approach whereby the structure is discretised into plies with different material properties corresponding to the different ply moisture content. The proposed method has been validated against finite element solutions, and results from its application on a fully characterised EDT (technical name) polymer binder are presented. The impact of the moisture induced viscoelastic behaviour on the structural response of the cas…

Caracterización de protones acelerados por láser y estudio de aplicaciones médicas

2017

El desarrollo de técnicas de amplificación láser durante las últimas décadas [1] ha derivado en una tecnología capaz de generar pulsos ultracortos, decenas de femtosegundo, y ultraintensos, en el orden del terawatio-petawatio. Estos pulsos pueden ser utilizados como vehículo para la aceleración de partículas hasta energías multi-MeV [2]. Esto ha generado un gran interés de la comunidad científica por la posibilidad de utilizar esta tecnología, que podría tener virtudes frente a los mecanismos de aceleración convencionales, además de ser un terreno inexplorado. El objetivo principal es el diseño de un experimento, detectores de partículas, y todos los periféricos necesarios para demostrar la…

Search for a Dark Leptophilic Scalar in e(+) e(-) Collisions

2020

Many scenarios of physics beyond the standard model predict the existence of new gauge singlets, which might be substantially lighter than the weak scale. The experimental constraints on additional scalars with masses in the MeV to GeV range could be significantly weakened if they interact predominantly with leptons rather than quarks. At an e+e- collider, such a leptophilic scalar (φL) would be produced predominantly through radiation from a τ lepton. We report herein a search for e+e-→τ+τ-φL, φL→ℓ+ℓ- (ℓ=e, μ) using data collected by the BABAR experiment at SLAC. No significant signal is observed, and we set limits on the φL coupling to leptons in the range 0.04<mφL<7.0 GeV. These bounds s…