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showing 10 items of 4562 documents
Changes in Pelvic Floor Muscle Tone after ‘Jumping Fitness’ Training—A Case Stud
2021
Aims Previous studies confirm the existence of a beneficial component of mechanical vibration and oscillation during trampoline exercises. Researchers have been interested in the possibility of using these exercises in the process of strengthening pelvic floor muscles and in cases of stress urinary incontinence. This study aimed to evaluate changes in pelvic floor muscle tone after 8 weeks of systematic ‘jumping fitness’ training and performing a follow-up observation of the maintenance of this effect after 9 months. Case report This study involved a young woman without symptoms of stress urinary incontinence who began practicing ‘jumping fitness’ 3 times a week for 2 months. After the end …
Exercise and Recovery Responses of Lymphokines to Heavy Resistance Exercise
2000
To examine the effect of dynamic resistance exercise on the response patterns of lymphokines, 10 strength-trained men (21.7 +- 0.6 y) performed 2 resistance exercise protocols, high force (HF) and high power (HP), of equal total work (HF 5 33.0 +- 2.5 kJ; HP 5 33.3 +- 2.7 kJ) in a randomized order separated by 1 week. Resting blood samples were obtained preexercise and 0 (R-0), 15 (R-15), and 240 (R-240) minutes postexercise. Plasma lactate significantly (p < 0.05) increased from baseline for both protocols; however, concentrations were higher in response to the HF protocol. Plasma interleukin- 2 (IL-2) concentrations were significantly decreased from baseline at R-15 following the HF proto…
Efficient 3D Deep Learning for Myocardial Diseases Segmentation
2021
Automated myocardial segmentation from late gadolinium enhancement magnetic resonance images (LGE-MRI) is a critical step in the diagnosis of cardiac pathologies such as ischemia and myocardial infarction. This paper proposes a deep learning framework for improved myocardial diseases segmentation. In the first step, we build an encoder-decoder segmentation network that generates myocardium and cavity segmentations from the whole volume, followed by a 3D U-Net based on Shape prior to identifying myocardial infarction and myocardium ventricular obstruction (MVO) segmentations from the encoder-decoder prediction. The proposed network achieves good segmentation performance, as computed by avera…
Regulation of glomerular basement membrane collagen expression by LMX1B contributes to renal disease in nail patella syndrome.
2001
Basement membrane (BM) morphogenesis is critical for normal kidney function. Heterotrimeric type IV collagen, composed of different combinations of six alpha-chains (1-6), is a major matrix component of all BMs (ref. 2). Unlike in other BMs, glomerular BM (GBM) contains primarily the alpha 3(IV) and alpha 4(IV) chains, together with the alpha 5(IV) chain. A poorly understood, coordinated temporal and spatial switch in gene expression from ubiquitously expressed alpha 1(IV) and alpha 2(IV) collagen to the alpha 3(IV), alpha 4(IV) and alpha 5(IV) chains occurs during normal embryogenesis of GBM (ref. 4). Structural abnormalities of type IV collagen have been associated with diverse biological…
Integrative transnational analysis to dissect tuberculosis transmission events along the migratory route from Africa to Europe
2021
páginas, 4 figuras, 3 tablas
Liver specific deletion of CYLDexon7/8 induces severe biliary damage, fibrosis and increases hepatocarcinogenesis in mice
2012
Background & Aims CYLD is a tumor suppressor gene that is mutated in familial cylindromatosis, an autosomal dominant predisposition to tumors of skin appendages. Reduced CYLD expression has been observed in other tumor entities, including hepatocellular carcinoma. In the present study, we analyzed the role of CYLD in liver homeostasis and hepatocarcinogenesis in vivo . Methods Mice with liver-specific deletion of CYLDexon7/8 ( CYLD FF xAlbCre ) were generated. Liver tissues were histologically analyzed and oval cell activation was investigated. Hepatocarcinogenesis was induced by diethylnitrosamine/phenobarbital (DEN/PB). Microarray expression profiling of livers was performed in untreated …
Adriamycin Permeability of the Rat Bladder under Different Conditions
1983
Abstract Fifty female Sprague-Dawley rats were treated with 1.4 or 2.4 mg. adriamycin intravesically. Radioimmunological measurement of serum concentrations were performed up to 3 hours post-instillation in normal bladder mucosa, cystitis, and after electrocoagulation, under different filling conditions, as well as with the use of a detergent (Tween 80). The serum concentrations achieved were markedly higher after electrocoagulation or cystitis; altogether they reached only 1/6,000 of the instilled concentration. These studies on the rat bladder suggest that perioperative instillation of adriamycin to prevent recurrence is not contraindicated shortly before or after transurethral resection …
Dopaminergic modulation of evoked vasopressin release from the isolated neurohypophysis of the rat
1982
1. Neurointermediate lobes of rat pituitaries were incubated in Locke or Krebs solution, and the vasopressin released into the medium was assayed on the blood pressure of the pithed rat or by a radioimmunological procedure. Release of vasopressin over resting levels was evoked either by incubation with 60 mM KCl (high K) solution or by electrical stimulation of the pituitary stalk. Two different kinds of electrical stimulation were carried out. Procedure A (1 ms, 10 Hz, 5 times for 1 min within 10 min) induced a vasopressin overflow which was greatly calcium-dependent but only insignificantly sensitive to tetrodotoxin (TTX). Procedure B (0.2 ms, 15 Hz, 10 s trains with 10 s intervals for 10…
Differential effects of potassium channel blockers on neurohypophysial release of oxytocin and vasopressin. Evidence for frequency-dependent interact…
1988
Isolated rat neurohypophyses were fixed by their stalks to a platinum wire electrode and superfused with Krebs-HEPES solution. Vasopressin and oxytocin released into the medium were determined by specific radioimmunoassays. Hormone secretion was increased by electrical stimulation of the pituitary stalk at different frequencies. The effects of several potassium channel blockers, tetraethylammonium (TEA) ions, 4-aminopyridine (4-AP) and 3,4-diaminopyridine (3,4-DAP) were tested. The release of vasopressin and oxytocin evoked by electrical stimulation with 900 pulses at 15 Hz (about 900 and 1,000 μU, respectively) was about 10 times higher than that evoked by 900 pulses at 3 Hz. Both 10 and 3…
Clinical experience with retrievable vena cava filters: results of a prospective observational multicenter study
2005
Summary. Background: Retrievable inferior vena cava (IVC) filters offer the attractive possibility to be definitive or to be removed when they become unnecessary. Objective: The purpose of this study was to evaluate the efficacy and the likelihood to remove the retrievable IVC filter ALN. Methods: A total of 30 patients (13 males and 17 females, mean age 57 ± 15 years) underwent placement of ALN filters. Indications for implantation were acute venous thromboembolism (VTE) with a contraindication to anticoagulation in 26 cases (86%), primary prophylaxis after major trauma in two cases (7%) or before surgery in two patients with very high thromboembolic risk (7%). Results: The filter was succ…