Search results for "trauma"

Exploring the Virchow-Robin spaces function: A unified theory of brain diseases.

2016

Background: Cerebrospinal fluid (CSF) transport across the central nervous system (CNS) is no longer believed to be on the conventional lines. The Virchow-Robin space (VRS) that facilitates CSF transport from the basal cisterns into the brain interstitial fluid (ISF) has gained interest in a whole new array of studies. Moreover, new line of evidence suggests that VRS may be involved in different pathological mechanisms of brain diseases. Methods: Here, we review emerging studies proving the feasible role of VRS in sleep, Alzheimer's disease, chronic traumatic encephalopathy, and traumatic brain injury (TBI). Results: In this study, we have outlined the possible role of VRS in different path…

The Blood–Brain Barrier as a Target in Traumatic Brain Injury Treatment

2014

Traumatic brain injury (TBI) is one of the most frequent causes of death in the young population. Several clinical trials have unsuccessfully focused on direct neuroprotective therapies. Recently immunotherapeutic strategies shifted into focus of translational research in acute CNS diseases. Cross-talk between activated microglia and blood–brain barrier (BBB) could initiate opening of the BBB and subsequent recruitment of systemic immune cells and mediators into the brain. Stabilization of the BBB after TBI could be a promising strategy to limit neuronal inflammation, secondary brain damage and acute neurodegeneration. This review provides an overview on the pathophysiology of TBI and brain…

A PCA Interpretation of the Glasgow Coma Scale in the Trauma Brain Injury PECARN Dataset

2018

CT scan is strongly recommended for a patient affected by head trauma, but he/she must absorb a certain amount of radiations. For this reason, the physician tries to avoid such a practice for pediatric patients. The symptoms analysis, visual/tactile inspection, and reactions to appropriate stimuli from the physician could induce him/her to put the patient in a period of observation instead of performing an immediate CT scan. As a consequence, the correct evaluation of those symptoms is a crucial task. For this reason, the Pediatric Glasgow Coma Scale (PGCS) plays a fundamental role, because it is a numeric scale regarding the patient’s mental status. It is computed as the sum of the score f…

Interactive Guidance Intervention to Address Sustained Social Withdrawal in Preterm Infants in Chile: Protocol for a Randomized Controlled Trial

2020

Background Preterm newborns can be exposed early to significant perinatal stress, and this stress can increase the risk of altered socioemotional development. Sustained social withdrawal in infants is an early indicator of emotional distress which is expressed by low reactivity to the environment, and if persistent, is frequently associated with altered psychological development. Infants born prematurely have a higher probability of developing sustained social withdrawal (adjusted odds ratio 1.84, 95% CI 1.04-3.26) than infants born full term, and there is a correlation between weight at birth and sustained social withdrawal at 12 months of age. Objective The aims of this study are to comp…

Tinnitus with Headaches

2011

1. Patients with tinnitus frequently have headaches, but the relation between these two disorders is not always casual. 2. Headaches and tinnitus could be symptoms of the same disease. 3. Idiopathic intracranial hypertension is a syndrome in which headaches and tinnitus often occur together. 4. Headaches and tinnitus often occur together with other focal symptoms in symptomatic intracranial hypertension. 5. Intracranial vascular abnormalities such as arteriovenous malformations (AVMs) can occur together with any kind of headache with paroxysmal tinnitus. 6. Tinnitus may be one of the signs of a basilar migraine. 7. Headaches are a very frequent symptom after head trauma, and tinnitus is als…

Mourning within families, the usage of Rorschach regarding the assessment on the consequences of the trauma

2005

Long‐term molecular differences between resilient and susceptible mice after a single traumatic exposure

2022

Post-traumatic stress disorder (PTSD) is a heterogeneous disorder induced by trauma, resulting in severe long-term impairments of an individual's mental health. PTSD does not develop in every individual and, thus, some individuals are more resilient. However, the underlying molecular mechanisms are poorly understood. Here, we aimed to elucidate these processes.We used a single-trauma PTSD model in mice to induce long-term maladaptive behaviours and profiled the mice 4 weeks after trauma into resilient or susceptible individuals. The classification of phenotype was based on individual responses in different behavioural experiments. We analysed microbiome, circulating endocannabinoids, and lo…

Salvage treatment with ganciclovir in a splenectomized, polytransfused patient affected by systemic inflammatory response syndrome

2014

A 23-year-old man was admitted to hospital with a 12-day history of daily fever. A clinical history revealed that 10 months previously, the patient had been splenectomized and polytransfused for a severe blunt trauma. On admission, laboratory data revealed significant leukocytosis (33,230/ul). The patient's general clinical conditions rapidly worsened into a severe systemic inflammatory response syndrome in four days. After 10 days of broad-spectrum antibiotic treatment, the temperature curve was unmodified and severe leukocytosis persisted (44,300 ul) with absolute lymphocytosis. Laboratory tests ruled out hematological diseases, pneumonia, abscesses and endocarditis. In the light of IgM …

Endocannabinoid signals in the control of emotion.

2008

The appropriate control of emotional responses evoked by environmental stimuli is an important innate mechanism for ensuring quality of life and even for survival. Inappropriate responses and decreased abilities to adjust to changed environmental situations can lead to psychiatric disorders, such as posttraumatic stress disorders, phobia and depression. Endocannabinoid signalling has emerged as one of the regulatory systems of the brain supporting appropriate emotional responses. As various components of the endocannabinoid system have become therapeutic targets, understanding the endocannabinoids’ mechanism of action is an important research topic for a rationalized drug design and optimal…

A novel arousal-based individual screening reveals susceptibility and resilience to PTSD-like phenotypes in mice

2021

Translational animal models for studying post-traumatic stress disorder (PTSD) are valuable for elucidating the poorly understood neurobiology of this neuropsychiatric disorder. These models should encompass crucial features, including persistence of PTSD-like phenotypes triggered after exposure to a single traumatic event, trauma susceptibility/resilience and predictive validity. Here we propose a novel arousal-based individual screening (AIS) model that recapitulates all these features. The AIS model was designed by coupling the traumatization (24 h restraint) of C57BL/6 J mice with a novel individual screening. This screening consists of z-normalization of post-trauma changes in startle …