Search results for "treatment options"

Treatment of cutaneous lupus erythematosus: current practice variations

2015

The treatment of cutaneous lupus erythematous (CLE) remains a challenge. Most of the therapeutic options used in CLE have not been tested in randomized controlled studies and to date no agent has been approved. Therefore, CLE treatment is mostly based on personal experience. To better characterize therapeutic habits among physicians treating CLE patients, a questionnaire-based study about various aspects of topical and systemic treatment for CLE has been performed. The questionnaire was distributed among CLE experts, mostly from Japan, the USA, and Europe. A total of 82 completed questionnaires were assessed. High-potent and potent corticosteroids as well as calcineurin inhibitors were the…

25 HUMAN SURROGATE MODELS OF PAIN MEMORY: IMPLICATIONS FOR MECHANISMS OF CENTRAL SENSITIZATION AND RELATED TREATMENT OPTIONS IN NEUROPATHIC PAIN PATI…

2007

Budesonide in previously untreated autoimmune hepatitis

2005

Background: Autoimmune hepatitis (AIH) is a chronic liver disease that is effectively treated with immunosuppressive therapy. Predniso(lo)ne, often in combination with azathioprine, is the basic therapeutic option to induce remission. However, this regimen can cause numerous side effects. The aim of the present study was to evaluate budesonide as a treatment option in the induction of remission in patients with previously untreated AIH. Methods: Between October 1998 and August 1999, 12 patients were treated with 3 mg budesonide thrice daily for 3 months in this open one-arm multicenter phase IIa study. Primary end point was induction of remission indicated by a drop of aspartate aminotransf…

Unknown primary tumors

2011

An unknown primary tumor (UPT) is defined by the presence of a metastatic cancer without a known primary site of origin despite a standardized diagnostic workup. Clinically, UPTs show rapid progression and early dissemination, with signs and symptoms related to the metastatic site. The molecular bases of their biology remain largely unknown, with no evidence as to whether they represent a distinct biological entity. Immunohistochemistry remain the best diagnostic tool in term of cost-effectiveness, but the time-consuming "algorithmic process" it relies on has led to the application of new molecular techniques for the identification of the primary site of UPTs. For example, several microarra…

Glutamate Excitotoxicity in the Cerebellum Mediated by IL-1β

2013

Multiple sclerosis (MS) is the prototypic inflammatory demyelinating disorder of the CNS. Symptoms of cerebellar dysfunction, such as tremors and ataxia, are relatively common in MS, but available treatment options are generally of limited value. Although many clinical manifestations of MS are

Actitudes hacia la maternidad y el apoyo social como predictores de trastornos emocionales en mujeres jóvenes con cáncer recientemente diagnosticadas…

1970

espanolObjetivo. Mujeres jovenes con cancer pueden beneficiarse de opciones para la preservacion de su fertilidad. Se necesitan estudios que determinen las implicaciones psicologicas de someterse a estas tecnicas y de la propia decision de recibirlas. Este estudio analiza el distres emocional, las preocupaciones sobre la fertilidad, las actitudes ante la maternidad, la satisfaccion con la informacion recibida y el apoyo social en mujeres con cancer que reciben un tratamiento de preservacion de la fertilidad. Metodo. Una muestra de 115 mujeres (edad media 31 anos) recien diagnosticas de cancer fueron evaluadas (Entrevista semiestructurada, Escala de apoyo social percibido, BSI-18) el mismo d…

Influence of bruxism on survival of porcelain laminate veneers

2013

Objectives: This study aims to determine whether bruxism and the use of occlusal splints affect the survival of porcelain laminate veneers in patients treated with this technique. Material and Methods: Restorations were made in 70 patients, including 30 patients with some type of parafunc - tional habit. A total of 323 veneers were placed, 170 in patients with bruxism activity, and the remaining 153 in patients without it. A clinical examination determined the presence or absence of ceramic failure (cracks, frac - tures and debonding) of the restorations; these incidents were analyzed for association with bruxism and the use of splints. Results: Analysis of the ceramic failures showed that …

A survey of dentists' practice in the restoration of the shortened dental arch.

2010

Objectives: The aim of this survey was to determine how a sample of dentists working in general dental practice in the UK sought to restore the mouths of patients who had shortened dental arches (SDAs). Study design: A survey was conducted over a period of six months on four commercial dental laboratories. Cases of SDAs comprising the anterior teeth and 2 to 4 premolars were examined; dental prescriptions were scrutinized and a special data collection form was completed accordingly. Results: A total of 140 SDA cases were examined. Most of these cases were for mandibular SDAs (88.6%). Of the recorded SDA cases, 67.2% were restored by cobalt-chromium based removable partial dentures (RPD); 25…

Dentist´s knowledge, attitudes and determining factors of the conservative approach in teeth with reversible pulpitis and deep caries lesions

2018

Background The aim of this study was to investigate dentists` knowledge, attitudes and factors regarding the conservative approach in the management of deep caries lesions (DCLs) in teeth with reversible pulpitis. Material and methods 187 dentists were contacted directly or by mail, and 125 (67%) were finally included in the study. Dentists were requested to answer an open/discursive questionnaire about the routine approach to the diagnosis and treatment of DCLs, including knowledge-related attitudinal items. Results Total caries excavation was the preferred treatment option for more than 80% of dentists in case of DCL with reversible pulpitis. Only a small percentage (8%) chose partial car…

AGO Algorithms for the Treatment of Breast Cancer: Update 2021

2021

Geburtshilfe und Frauenheilkunde 81(10), 1101-1111 (2021). doi:10.1055/a-1519-7089