Search results for "trial design"
showing 10 items of 26 documents
Changes in myocardial iron content following administration of intravenous iron (Myocardial‐IRON): Study design
2018
Treatment with intravenous ferric carboxymaltose (FCM) has been shown to improve symptoms, functional capacity, and quality of life in patients with heart failure and iron deficiency. However, the underlying mechanisms for these beneficial effects remain undetermined. The aim of this study is to quantify cardiac magnetic resonance changes in myocardial iron content after administration of intravenous FCM in patients with heart failure and iron deficiency and contrast them with parameters of heart failure severity. This is a multicenter, double-blind, randomized study. Fifty patients with stable symptomatic heart failure, left ventricular ejection fraction <50%, and iron deficiency will be r…
Determinants of silent and explicit industrial design
2018
This paper investigates the relationship between the use of silent or explicit design (SD or ED) and the characteristics of firms or sectors that use each of these types of design in Argentina. The findings show that SD differs from ED and that the differences have important implications for the creation of policies to support competitiveness as well as for the development of business strategies. The study contributes to the literature by identifying three groups of dimensions. (1) Structural. Neither size nor barriers to the use of design bear relation to the use of design. (2) Dynamic. SD and ED have different effects on competitiveness based on the different links each type of design has…
A multi-technique simultaneous approach for the design of a sailing yacht
2015
In this paper, most significant steps involved during the whole process of designing a sailing yacht are outlined. In particular, a novel simultaneous approach has been proposed to optimize the design process of a sailing yacht. Analytical resistance prediction models are simultaneously used with CAD systems and computational fluid dynamics tools to find, in the more effective way, the best solution for the chosen design conditions. As a general rule, in fact, once the target point has been decided, task of the designer is the definition of those systems of aerodynamic and hydrodynamic forces that are in equilibrium when the boat sails at its target. Unfortunately, a multi-purpose yacht doe…
The role of representation and technology in product configuration.
2017
The relationship between design and visualization requires considerations about methods and techniques of representation. This is especially important today, even for industrial products as information technology is affecting their visualization and product configurator are changing the relationship among the actors involved in their production.
Utilizing Experience Goals in Design of Industrial Systems
2017
The core idea of experience-driven design is to define the intended experience before functionality and technology. This is a radical idea for companies that have built their competences around specific technologies. Although many technology companies are willing to shift their focus towards experience-driven design, reports on real-life cases about the utilization of this design approach are rare. As part of an industry-led research program, we introduced experience-driven design to metal industry companies with experience goals as the key technique. Four design cases in three companies showed that the goals are useful in keeping the focus on user experience, but several challenges are sti…
A new design approach for customised medical devices realized by additive manufacturing
2020
AbstractThe aim of this work is the design of a new customised elbow orthosis completely realized by Additive Manufacturing and the development of generative algorithms for parametric modelling and creation of 3D patterns to be adapted to the CAD model. This work describes a method to perfect the design of a custom elbow orthosis. A reverse engineering approach has been used to digitalize the patient’s arm and the subsequent CAD modelling of the structure of the custom elbow orthosis has been performed. In particular, two algorithms have been implemented for the creation of 3D patterns and Voronoi tessellations. Subsequently, FEM analyses have been carried out to validate the design. Finall…
Conversazione con Philippe Daverio tra Design e Beni Culturali | Conversation with Philippe Daverio between Design and Cultural Assets
2016
Il design per la valorizzazione dei Beni Culturali è tema oggi decisa- mente attuale. Philippe Daverio risponde a questioni generali dicendo la sua: sull’incidenza delle nuove tecnologie nella fruizione dei musei e delle opere, sul redesign applicato alla rigenerazione della città, sull’importanza dei musei storici quali espressioni della cultura stratificata, sul valore civico ed etico del progetto e sulle riedizioni di mobili che hanno fatto la storia del design. Design for the enhancement of the Cultural Heritage is today an issue of great topical interest. Philippe Daverio answers general questions to express his own opinion regarding the effect of new technology in the fruition of muse…
A Novel Visual Interface to Foster Innovation in Mechanical Engineering and Protect from Patent Infringement
2018
One of the main time and money consuming tasks in the design of industrial devices and parts is the checking of possible patent infringements. Indeed, the great number of documents to be mined and the wide variety of technical language used to describe inventions are reasons why considerable amounts of time may be needed. On the other hand, the early detection of a possible patent conflict, in addition to reducing the risk of legal disputes, could stimulate a designers' creativity to overcome similarities in overlapping patents. For this reason, there are a lot of existing patent analysis systems, each with its own features and access modes. We have designed a visual interface providing an …
The calm before the storm: a report from the International Liver Cancer Association Congress 2015 – part 1
2016
International Liver Cancer Association Congress 2015, Paris, France, 4–6 September 2015 Since its creation 9 years ago, in 2007, the International Liver Cancer Association has focused on the multidisciplinary approach to liver cancer due to advances in hepatology science and care worldwide. In its 2015 annual conference, held on 4–6 September in Paris, France, the most recent progresses in the basic biology, management and treatment of liver cancer have been presented. This report, divided into two parts, introduces and critically reviews some of the most intriguing topics discussed at the meeting.
Sperata resilienza
2018
Il termine ‘resilienza’ proveniva dalla metallurgia: indica, nella tecnologia metallurgica, la capacità di un metallo di resistere alle forze che vi vengono applicate. Per un metallo, la resilienza rappresenta il contrario della fragilità. Così anche in campo psicologico: la persona resiliente è l’opposto di una facilmente vulnerabile, ovvero che vive: la Notte dell’io (Mormese C., 2004). Etimologicamente ‘resilienza’ viene fatta deriva dal latino resalio, iterativo di salio. Qualcuno propone un collegamento suggestivo fra il signiicato originario di resalio, che connotava anche il gesto dell’uomo di risalire sull’imbarcazione capovolta dalla forza del mare, e l’attuale utilizzo in campo ps…