Search results for "tumori"
showing 10 items of 62 documents
The Friedreich's Ataxia protein frataxin modulates DNA base excision repair in prokaryotes and mammals
2010
DNA-repair mechanisms enable cells to maintain their genetic information by protecting it from mutations that may cause malignant growth. Recent evidence suggests that specific DNA-repair enzymes contain ISCs (iron–sulfur clusters). The nuclearencoded protein frataxin is essential for the mitochondrial biosynthesis of ISCs. Frataxin deficiency causes a neurodegenerative disorder named Friedreich's ataxia in humans. Various types of cancer occurring at young age are associated with this disease, and hence with frataxin deficiency. Mice carrying a hepatocyte-specific disruption of the frataxin gene develop multiple liver tumours for unresolved reasons. In the present study, we show that frata…
Classification or non-classification of substances with positive tumor findings in animal studies: Guidance by the German MAK commission
2019
One of the important tasks of the German Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area (known as the MAK Commission) is in the evaluation of a potential for carcinogenicity of hazardous substances at the workplace. Often, this evaluation is critically based on data on carcinogenic responses seen in animal studies and, if positive tumor responses have been observed, this will mostly lead to a classification of the substance under investigation into one of the classes for carcinogens. However, there are cases where it can be demonstrated with a very high degree of confidence that the tumor findings in the experimental animals are not relevant…
Cell Systems Bioelectricity: How Different Intercellular Gap Junctions Could Regionalize a Multicellular Aggregate
2021
Simple Summary Electric potential patterns across tissues are instructive for development, regeneration, and tumorigenesis because they can influence transcription, migration, and differentiation through biochemical and biomechanical downstream processes. Determining the origins of the spatial domains of distinct potential, which in turn decide anatomical features such as limbs, eyes, brain, and heart, is critical to a mature understanding of how bioelectric signaling drives morphogenesis. We studied theoretically how connexin proteins with different voltage-gated gap junction conductances can maintain multicellular regions at distinct membrane potentials. We analyzed a minimal model that i…
miR-205-5p-mediated downregulation of ErbB/HER receptors in breast cancer stem cells results in targeted therapy resistance
2015
AbstractThe ErbB tyrosine kinase receptor family has been shown to have an important role in tumorigenesis, and the expression of its receptor members is frequently deregulated in many types of solid tumors. Various drugs targeting these receptors have been approved for cancer treatment. Particularly, in breast cancer, anti-Her2/EGFR molecules represent the standard therapy for Her2-positive malignancies. However, in a number of cases, the tumor relapses or progresses thus suggesting that not all cancer cells have been targeted. One possibility is that a subset of cells capable of regenerating the tumor, such as cancer stem cells (CSCs), may not respond to these therapeutic agents. Accumula…
Molecular Mechanisms Leading from Periodontal Disease to Cancer
2022
Periodontitis is prevalent in half of the adult population and raises critical health concerns as it has been recently associated with an increased risk of cancer. While information about the topic remains somewhat scarce, a deeper understanding of the underlying mechanistic pathways promoting neoplasia in periodontitis patients is of fundamental importance. This manuscript presents the literature as well as a panel of tables and figures on the molecular mechanisms of Porphyromonas gingivalis and Fusobacterium nucleatum, two main oral pathogens in periodontitis pathology, involved in instigating tumorigenesis. We also present evidence for potential links between the RANKL–RANK signaling axi…
Multiparametric-MRI evaluation of cervical nodes in patients with head and neck squamous cell carcinoma (HNSCC)
Il Registro incontra i Sindaci: l’iniziativa di comunicazione del Registro Tumori di Palermo e Provincia
2015
Registri Tumori; epidemiologia tumori; comunicazione rischio oncologico
I TUMORI PRIMITIVI DEL TESTICOLO IN ETA' PEDIATRICA
1994
Gli Autori riportano la casistica nazionale sui Tumori primitici del testicolo in età pediatrica e ne valutano i risultati
UNA RARITA' ISTOLOGICA IN ONCOLOGIA PEDIATRICA: L'EMANGIOPERICITOMA MALIGNO CONGENITO.
1989
Gli Autori riportano un caso di Emangiopericitoma congenito a rarissima localizzazione retroperitoneale. Dopo revisione della letteratura e discussione del caso, si evidenziano le difficoltà diagnostiche nei confronti di altre masse retroperitoneali ed il ruolo preminente della chirurgia nella terapia di queste neoplasie.
TUMORI MALIGNI RARI NEL BAMBINO: DATI DA UNO STUDIO RETROSPETTIVO MULTICENTRICO
1994
Le neoplasie con incidenza annuale inferiore a 2 casi per milione di bambini sono considerate rare. Allo scopo di valutare l'esperienza dei pricipali Centri pediatrici e chirurgici-pediatrici su tumori maligni rari attualmente non registrati in protocolli nazionali, è stato condotto uno studio retrospettivo cooperativo. Sono stati registrati 164 pazienti osservati in 34 Centri Italiani dal 1982 al 1993.