Search results for "type 2 diabetes mellitus"
showing 8 items of 198 documents
The importance of diagnosing the Polycystic Ovary Syndrome
2000
The polycystic ovary syndrome (PCOS) is an extremely common disorder that occurs in 4% to 7% of women of reproductive age. Although PCOS is known to be associated with reproductive morbidity and increased risk for endometrial cancer, diagnosis is especially important because PCOS is now thought to increase metabolic and cardiovascular risks. These risks are strongly linked to insulin resistance and are compounded by the common occurrence of obesity, although insulin resistance and its associated risks are also present in nonobese women with PCOS. Women with PCOS are at increased risk for impaired glucose tolerance, type 2 diabetes mellitus, and hypertension. Cardiovascular disease is believ…
Disturbed Glucose Metabolism and Left Ventricular Geometry in the General Population
2021
Background: This study sought to investigate the prevalence and clinical outcome of left ventricular (LV) geometry in prediabetes and type 2 diabetes mellitus (T2DM) and the impact of glucose metabolism on the incidence of left ventricular hypertrophy (LVH). Methods: 15,010 subjects (35–74 years) of the population-based Gutenberg Health Study were categorized into euglycemia, prediabetes, and T2DM according to clinical and metabolic (HbA1c) information. Clinical outcome was assessed via structured follow-up. Results: The study comprised 12,121 individuals with euglycemia (81.6%), 1415 with prediabetes (9.5%), and 1316 with T2DM (8.9%). Prevalence of LVH increased from euglycemia (10.2%) ove…
Effect of insulin on readmission for heart failure following a hospitalization for acute heart failure
2020
AIMS: Type 2 diabetes mellitus (T2DM) is common in patients with heart failure (HF) and is related with worse outcomes. Insulin treatment is associated with sodium and water retention, weight gain, and hypoglycaemia-all pathophysiological mechanisms related to HF decompensation. This study aimed to evaluate the association between insulin treatment and the risk of 1year readmission for HF in patients discharged for acute HF.; METHODS AND RESULTS: We prospectively included 2895 consecutive patients discharged after an episode of acute HF in a single tertiary hospital. Multivariable Cox regression, adapted for competing events, was used to assess the association between insulin treatment and …
Impact of Glucose-Lowering Medications on Cardiometabolic Risk in Type 2 Diabetes
2019
Type 2 Diabetes Mellitus (T2DM) is associated with a high risk of atherosclerotic cardiovascular (CV) disease. Contributing pathophysiologic factors include endothelial dysfunction caused by excessive production of reactive oxygen species (ROS), increased activity of nuclear factor kB (NFkB), altered macrophage polarization, and reduced synthesis of endothelial progenitor cells (EPC). Consequently, there can be a potentially rapid progression of the atherosclerotic disease with a higher propensity to unstable plaque, leading to increased cardiovascular mortality. Management is aimed at prevention, early diagnosis, and treatment of hyperglycemia and vascular complications. Innovative therape…
New developments in the pathogenesis of obesity-induced hypertension
2015
Obesity is a disorder that develops from the interaction between genotype and environment involving social, behavioral, cultural, and physiological factors. Obesity increases the risk for type 2 diabetes mellitus, hypertension, cardiovascular disease, cancer, musculoskeletal disorders, chronic kidney and pulmonary disease. Although obesity is clearly associated with an increased prevalence of hypertension, many obese individuals may not develop hypertension. Protecting factors may exist and it is important to understand why obesity is not always related to hypertension. The aim of this review is to highlight the knowledge gap for the association between obesity, hypertension, and potential …
Melatonin Concentrations and Sleep Quality in Patients with Type 2 Diabetes and Obesity
2019
Abstract There is a close relationship between melatonin as a circadian regulator and insulin, glucagon and somatostatin production. This study aimed to describe subgroups of type 2 diabetes mellitus (T2DM) patients that may benefit from melatonin clock-targeting properties. The study involved 38 participants: 26 T2DM patients, and 12 participants without diabetes in the control group. Subjects were asked to complete the questionnaire of Pittsburgh Sleep Quality Index (PSQI). Standard biochemical venous sample testing was performed, and a sample of saliva was collected for melatonin testing. Melatonin concentration in participants without obesity (body mass index (BMI) < 30 kg/m2) was si…
Comparative analysis of socioeconomic, behavioral and biological factors between healthy patients and patients with newly diagnosed diabetes in the L…
2020
Introduction. The most effective way to prevent a dramatic increase in the number of diabetic patients lies in early detection of its risk factors and the diagnosis of carbohydrate metabolism disorders. Aim of the study. The study aims at determining socio-economic variables, lifestyle behaviours and biological factors differentiating patients with newly diagnosed diabetes from the diabetes-free individuals according to the American criteria issued by the Commission on Social Determinants of Health as well as FINDRISC form which helps identify patients who are at risk of developing diabetes type 2 on the basis of multi-factorial determinants of its development. Material and methods. The res…
Otrā tipa cukura diabēta pacientu līdzestība ārstēšanā un aprūpē
2020
Bakalaura darba tēma “Otrā tipa cukura diabēta pacientu līdzestība ārstēšanā un aprūpē”. Tēmas aktualitāti nosaka straujais cukura diabēta slimnieku skaita pieaugums pasaulē. Cukura diabēts ierindojas piektajā vietā pasaules izplatītāko mirstības cēloņu vidū, kā arī ir galvenais akluma, nieru mazspējas, infarkta, insulta un apakšējo ekstremitāšu amputācijas iemesls. Darba mērķis ir noskaidrot 2. tipa cukura diabēta pacientu līdzestību ārstēšanā un aprūpē. Pētījuma uzdevumi ir izpētīt zinātnisko literatūru par 2. tipa cukura diabētu un pacientu līdzestību ārstēšanās un atveseļošanās procesos. Raksturot Kalistas Rojas adaptācijas teoriju, un saistīt to ar pētījuma tēmu. Veikt pētījumu un inte…