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RESEARCH PRODUCT

Disturbed Glucose Metabolism and Left Ventricular Geometry in the General Population

Alexander K. SchusterAnna-maria BillaudellePhilipp S. WildAndreas SchulzMatthias MichalThomas KoeckSven-oliver TröbsKarsten KellerKarsten KellerKarl J. LacknerOmar HahadGerrit ToengesVolker SchmittThomas MünzelJürgen H. Prochaska

subject

medicine.medical_specialtyendocrine system diseasestype 2 diabetes mellitusPopulationprediabetesCarbohydrate metabolismleft ventricular concentric remodelingLeft ventricular hypertrophyArticleInternal medicineMedicineMass indexPrediabetescardiovascular diseaseseducationeducation.field_of_studybusiness.industryIncidence (epidemiology)Hazard ratioRType 2 Diabetes Mellitusnutritional and metabolic diseasesGeneral Medicinemedicine.diseaseleft ventricular hypertrophyleft ventricular geometryCardiologyMedicinebusiness

description

Background: This study sought to investigate the prevalence and clinical outcome of left ventricular (LV) geometry in prediabetes and type 2 diabetes mellitus (T2DM) and the impact of glucose metabolism on the incidence of left ventricular hypertrophy (LVH). Methods: 15,010 subjects (35–74 years) of the population-based Gutenberg Health Study were categorized into euglycemia, prediabetes, and T2DM according to clinical and metabolic (HbA1c) information. Clinical outcome was assessed via structured follow-up. Results: The study comprised 12,121 individuals with euglycemia (81.6%), 1415 with prediabetes (9.5%), and 1316 with T2DM (8.9%). Prevalence of LVH increased from euglycemia (10.2%) over prediabetes (17.8%) to T2DM (23.8%). Prediabetes and T2DM were associated with increased LV mass index (prediabetes: β1.3 (95% CI 0.78–1.81), p &lt

yearjournalcountryeditionlanguage
2021-08-01Journal of Clinical Medicine
10.3390/jcm10173851http://dx.doi.org/10.3390/jcm10173851