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showing 10 items of 10618 documents
Psoriasis and Inflammatory Bowel Disease.
2018
<b><i>Background:</i></b> Inflammatory bowel disease (IBD) and psoriasis (PS) are associated conditions. The reason for this association lies in the sharing of predisposition genes and common immunological mechanisms. <b><i>Summary:</i></b> This review will focus on the interplay between IBD and PS, with details on prevalence and phenotype of PS in IBD, genetics, pathogenetic pathways, and therapy. <b><i>Key Messages:</i></b> Microbiome seems relevant in both conditions: a reduction of beneficial bacteria has been observed. IBD and PS have in common some comorbidities like cardiovascular disease, similar risk of cancer …
Diabetes and cancer: A critical appraisal of the pathogenetic and therapeutic links.
2014
Diabetes and cancer represent two common, multifactorial, chronic and potentially fatal diseases, not infrequently co-diagnosed in the same patient. Epidemiological data demonstrate significant increases of the cancer incidence in patients with obesity and diabetes, which is more evident for certain site-specific cancers. Although there is increasing evidence that strongly indicates an augmented risk of cancer in diabetic patients, several confounding factors complicate the ability to precisely assess the risk. Mainly in insulin-resistant states (such as in type 2 diabetes mellitus and in metabolic syndrome), direct associations between obesity-related hyperinsulinemia and increasing circul…
A generalizability measure for program synthesis with genetic programming
2021
The generalizability of programs synthesized by genetic programming (GP) to unseen test cases is one of the main challenges of GP-based program synthesis. Recent work showed that increasing the amount of training data improves the generalizability of the programs synthesized by GP. However, generating training data is usually an expensive task as the output value for every training case must be calculated manually by the user. Therefore, this work suggests an approximation of the expected generalization ability of solution candidates found by GP. To obtain candidate solutions that all solve the training cases, but are structurally different, a GP run is not stopped after the first solution …
High Order Textural Classification of Two SAR ERS Images on Mount Cameroon
2006
Abstract Many researchers have demonstrated that textural data increase the precision of a classification when they are combined with level of grey information. However, the calculation of textural parameters of order two is often too long in a computer. The problem is more complex when one must compute higher order textural parameters, which however can considerably improve the precision of a classification. This work is based on statistical methods of order two and three for the calculation of textural parameters [Akono et al., 2003]. In this work, we suggest a new method of calculation of textural parameters, which is more general, not limiting itself only on order two or three, but whic…
HLA genotype in patients with acquired haemophilia A
2010
Acquired haemophilia A (AH) is a rare bleeding disorder caused by an auto-antibody to coagulation factor VIII. It is associated with various autoimmune diseases, pregnancy, cancer or drug ingestion; however, in 50% of patients, no underlying disorder is found. In the present study, we investigated the association of HLA class I (A, B and Cw) and class II (DRB1 and DQB1) alleles with AH in a cohort of 57 patients. While no association with any class I allele was detected, a significantly higher frequency of DRB1*16 [odds ratio (OR) 10.2, 95%CI: 5.32-19.57, P < 0.0001] and DQB1*0502 (OR 2.2, 95%CI: 1.12-4.54, P < 0.05) was observed. In contrast, the frequency of DRB1*15 and DQB1*0602 alleles …
Long-Term Exposure to Transportation Noise and Risk for Type 2 Diabetes in a Nationwide Cohort Study from Denmark
2021
Background: Epidemiologic studies have linked transportation noise to increased morbidity and mortality, particularly for cardiovascular outcomes. However, studies investigating metabolic outcomes such as diabetes are limited and have focused only on noise exposures estimated for the loudest residential façade. Objectives: We aimed to examine the influence of long-term residential exposure to transportation noise at the loudest and quietest residential façades and the risk for type 2 diabetes. Methods: Road traffic and railway noise exposures (Lden) at the most and least exposed façades were estimated for all dwellings in Denmark during 1990–2017. Aircraft noise was estimated in 5-dB catego…
TYPE II DIABETES MELLITUS HAS NO MAJOR INFLUENCE ON PLATELET MICRO–RNA EXPRESSION: RESULTS FROM MICRO–ARRAY PROFILING IN A COHORT OF 60 PATIENTS
2013
Blood platelets represent pro–inflammatory mediators in the development of atherosclerosis. Diabetes mellitus as a major contributor to cardiovascular disease burden induces dysfunctional platelets. Platelets contain abundant miRNAs, which recently have been linked tightly to inflammation. While
Diet Rich in Plant Protein May Prevent Type 2 Diabetes
2020
Purpose : The aim is to show the ideal protein quality and quantity and the dietary composition for the prevention and metabolic control of type 2 diabetes mellitus (T2DM). Introduction Although some reviews demonstrate the advantages of a diet with a higher protein intake, other reviews have observed that a diet high in carbohydrates, with low-glycaemic index carbohydrates and good fibre intake, is equally effective in improving insulin sensitivity. Methods Over 2831 articles were screened, and 24 from the last 5 years were analysed and summarised for this review, using the protein, diabetes and insulin glucose metabolic keywords in Pubmed in June 2019. Results Eleven studies demonstrate t…
Applying logistic regression to relevance feedback in image retrieval systems
2007
This paper deals with the problem of image retrieval from large image databases. A particularly interesting problem is the retrieval of all images which are similar to one in the user's mind, taking into account his/her feedback which is expressed as positive or negative preferences for the images that the system progressively shows during the search. Here we present a novel algorithm for the incorporation of user preferences in an image retrieval system based exclusively on the visual content of the image, which is stored as a vector of low-level features. The algorithm considers the probability of an image belonging to the set of those sought by the user, and models the logit of this prob…
Knock out der c-Jun N-terminalen Kinase 2 (JNK2) aggraviert die Entwicklung der chronischen DSS-Colitis unabhängig von der intestinalen Zytokin-Expre…
2008
Background The c-Jun N-terminal kinase 2 (JNK2) is involved in signal transduction of inflammatory bowel diseases (IBD) and regulates the expression of pro-inflammatory cytokines. For this reason, JNK2 is considered as novel target for IBD therapy. The aim of this study was 1.) to examine the function of JNK2 applying a low dose Dextran Sulfate Sodium (DSS) model of chronic experimental colitis in JNK2 knock out mice and 2.) to analyze the expression of JNK2 dependent cytokines. Material and Methods: For induction of a mild chronic colitis, female JNK2 knockout mice (JNK2 ko) and their wildtype controls (WT2) received three cycles of DSS treatment, each consisting of 1.0 % DSS for 5 days, f…