Search results for "type"

Metformin Use and Cognitive Function in Older Adults With Type 2 Diabetes Following a Mediterranean Diet Intervention

2021

Background and Purpose: Both adherence to the Mediterranean diet (MedDiet) and the use of metformin could benefit the cognitive performance of individuals with type 2 diabetes, but evidence is still controversial. We examined the association between metformin use and cognition in older adults with type 2 diabetes following a MedDiet intervention. Methods: Prospective cohort study framed in the PREDIMED-Plus-Cognition sub-study. The PREDIMED-Plus clinical trial aims to compare the cardiovascular effect of two MedDiet interventions, with and without energy restriction, in individuals with overweight/obesity and metabolic syndrome. The present sub-study included 487 cognitively normal subjects…

Factors related to the difficulty of reading comprehension texts in the matriculation examination English tests

1997

Impact of biotic and abiotic factors on bacterial virulence

2013

Représentations de l'Autre dans l'interaction : stéréotypes, prototypes, sosies et barbares

2011

Cet article pose la question du recours par les individus aux stéréotypes, mais aussi à différentes modalités de représentation de l'Autre, dans une interaction interpersonnelle. Il insiste sur l'influence du contexte figuratif, pour tenter de comprendre les rapports d'intersubjectivité propres à chacune de ces modalités, mais aussi pour chercher à expliquer leur fonctionnement dynamique et les facteurs qui peuvent provoquer le passage d'une modalité à une autre au cours d'une rencontre. Cette réflexion permet de mettre en avant les conditions d'intersubjectivité particulières qui semblent caractériser la communication avec un Autre identifié comme " différent ", contrairement à la communic…

Prototypes nationaux et prototypes européens dans l'interaction interculturelle: Quelles valeurs identitaires pour une communication entre Européens ?

2007

23 pages; À partir d'une réflexion théorique sur les notions de prototype et de stéréotype, le texte s'appuie sur une enquête empirique sous forme de questionnaire, pour tenter de discerner quels peuvent être les traits d'un prototype européen. Il examine également les différences nationales qui peuvent exister entre les représentations de l'Européen typique.

Computable majorants of the limit load in Hencky’s plasticity problems

2018

Abstract We propose a new method for analyzing the limit (safe) load of elastoplastic media governed by the Hencky plasticity law and deduce fully computable bounds of this load. The main idea of the method is based on a combination of kinematic approach and new estimates of the distance to the set of divergence free fields. We show that two sided bounds of the limit load are sharp and the computational efficiency of the method is confirmed by numerical experiments.

Psychiatrists' Attitudes Toward Disruptive New Technologies: Mixed-Methods Study

2018

Background Recent discoveries in the fields of machine learning (ML), Ecological Momentary Assessment (EMA), computerized adaptive testing (CAT), digital phenotype, imaging, and biomarkers have brought about a new paradigm shift in medicine. Objective The aim of this study was to explore psychiatrists’ perspectives on this paradigm through the prism of new clinical decision support systems (CDSSs). Our primary objective was to assess the acceptability of these new technologies. Our secondary objective was to characterize the factors affecting their acceptability. Methods A sample of psychiatrists was recruited through a mailing list. Respondents completed a Web-based survey. A quantitative…

Model wielowymiarowej profilaktyki pozytywnej w teorii i praktyce pedagogicznej

2019

Artykuł opisuje teoretyczne oraz empiryczne założenia autorskiego modelu wielowymiarowej profilaktyki pozytywnej. Ponadto prezentuje sposób jego urzeczywistnienia w praktyce pedagogicznej, przedstawiając strukturę autorskiego programu profilaktycznego Wsparcie wielowymiarowego rozwoju młodzieży, zrealizowanego wśród wychowanków Domu Dziecka w Chmielowicach. Teoretyczne podstawy modelu odnoszą się do teorii głównych i teorii szczegółowych. Natomiast założenia empiryczne sprowadzają się do metodyki konstruowania programów profilaktycznych, a więc kryteriów doboru i metod oddziaływań profilaktycznych, uczestników oraz strategii ewaluacyjnej. Model wielowymiarowej profilaktyki pozytywnej w prak…

Pluripotent stem cells to model Hutchinson-Gilford progeria syndrome (HGPS): Current trends and future perspectives for drug discovery

2015

Progeria, or Hutchinson-Gilford progeria syndrome (HGPS), is a rare, fatal genetic disease characterized by an appearance of accelerated aging in children. This syndrome is typically caused by mutations in codon 608 (p.G608G) of the LMNA, leading to the production of a mutated form of lamin A precursor called progerin. In HGPS, progerin accumulates in cells causing progressive molecular defects, including nuclear shape abnormalities, chromatin disorganization, damage to DNA and delays in cell proliferation. Here we report how, over the past five years, pluripotent stem cells have provided new insights into the study of HGPS and opened new original therapeutic perspectives to treat the disea…

Epigenetic involvement in Hutchinson-Gilford progeria syndrome: a mini-review.

2013

Hutchinson-Gilford progeria syndrome (HGPS) is a rare human genetic disease that leads to a severe premature ageing phenotype, caused by mutations in the <i>LMNA</i> gene. The <i>LMNA</i> gene codes for lamin-A and lamin-C proteins, which are structural components of the nuclear lamina. HGPS is usually caused by a de novo <i>C1824T</i> mutation that leads to the accumulation of a dominant negative form of lamin-A called progerin. Progerin also accumulates physiologically in normal ageing cells as a rare splicing form of lamin-A transcripts. From this perspective, HGPS cells seem to be good candidates for the study of the physiological mechanisms of ageing…