Search results for "types"
showing 10 items of 956 documents
Moderna tiešsaistes pārdošanas dziņa izstrāde digitālās apdrošināšanas platformai
2019
Kvalifikācijas darba mērķis ir papildināt uzņēmuma SIA “Sapiens Software Solutions (Latvia)” izstrādātās Athena digitālo risinājumu platformas piedāvāto funkcionalitāti ar modulāru, viegli uzstādāmu un konfigurējamu tiešsaistes apdrošināšanas pārdošanas un uzturēšanas dzini Athena Journey, kas ļauj ātri un ērti izveidot specializētus tīmekļa risinājumus apdrošināšanas polišu pārdošanai un uzturēšanai. Izmantojot TypeScript programmēšanas valodu un JavaScript bibliotēku React, kvalifikācijas darba ietvaros tika izstrādāts spraudnis Athena platformā izstrādātam Athena Portal Plugin Framework spraudņu ietvaram, kas paredzēts modulāru vienas lapas tīmekļa portālu izveidei. Izstrādātais spraudni…
Tipizētās JavaScript valodas izmantošana tīmekļa lietojumprogrammu izstrādei
2015
Pēdējā laikā tīmekļa programmēšanā, precīzāk, tīmekļa lietojumprogrammu izstrādē, pieaug tipizēto JavaScript valodas paveidu popularitāte. Tie iekļauj JavaScript valodā statisko tipizāciju, kā arī vairākas tradicionālu objektorientētu valodu paradigmas. Pašlaik līderi šajā jomā ir Microsoft ar savu TypeScript valodu, bet arī Google un Facebook darbojās šajā virzienā – izstrādā, respektīvi, AtScript un Flow valodas. Maģistra darbā tiek izpētītas šo valodu iespējas, to atšķirības, kā arī tiek novērtēts to potenciāls, perspektivitāte un nozīme tīmekļa izstrādes attīstībai. Lai dziļāk izpētītu izstrādes procesa īpašības, kas ir saistītas ar tipizēto JavaScript valodas paveidu izmantošanu, autor…
α-parvin is required for epidermal morphogenesis, hair follicle development and basal keratinocyte polarity
2020
Epidermal morphogenesis and hair follicle (HF) development depend on the ability of keratinocytes to adhere to the basement membrane (BM) and migrate along the extracellular matrix. Integrins are cell-matrix receptors that control keratinocyte adhesion and migration, and are recognized as major regulators of epidermal homeostasis. How integrins regulate the behavior of keratinocytes during epidermal morphogenesis remains insufficiently understood. Here, we show that alpha-parvin (alpha-pv), a focal adhesion protein that couples integrins to actin cytoskeleton, is indispensable for epidermal morphogenesis and HF development. Inactivation of the murine alpha-pv gene in basal keratinocytes res…
Economics of Knowledge and Emergent Qualitative Changes
Economics of Knowledge and Emergent Qualitative Changes The traditional economics has its barycentre on the static equilibrium and on the allocation of the scarce resources for alternative uses, on the linear rationality. The economics of knowledge founds instead, upon a reflexive rationality, that has a long run, that acts as dynamic force does not management inside the usual trade-off of resources. The economics of knowledge and the real economy are changing deeply, the subjectivities that are compared through the market and in institutions they become less impersonal and less deterministic. Persons are entrusted less to the automatism of machines or organizational and they discover the r…
Do the current guidelines for heart failure diagnosis and treatment fit with clinical complexity?
2022
Heart failure (HF) is a clinical syndrome defined by specific symptoms and signs due to structural and/or functional heart abnormalities, which lead to inadequate cardiac output and/or increased intraventricular filling pressure. Importantly, HF becomes progressively a multisystemic disease. However, in August 2021, the European Society of Cardiology published the new Guidelines for the diagnosis and treatment of acute and chronic HF, according to which the left ventricular ejection fraction (LVEF) continues to represent the pivotal parameter for HF patients’ evaluation, risk stratification and therapeutic management despite its limitations are well known. Indeed, HF has a complex pathophys…
One Species, Hundreds of Subspecies? New Insight into the Intraspecific Classification of the Old World Swallowtail (Papilio machaon Linnaeus , 1758)…
2022
The Old World swallowtail Papilio machaon Linnaeus, 1758 is one of the most well-known and most characteristic members of the family Papilionidae. Over the past two centuries, the butterfly has been the subject of many studies. P. machaon is characterised by a tendency to change the wing colour pattern. In turn, due to the great interest of collectors and amateur entomologists, these studies have been converted into the description of over 100 colour forms, aberrations and subspecies. In this study, mitochondrial DNA (mtDNA), 16S rDNA and cytochrome b sequences were used to examine the correlation between the intraspecific classification and genetic structure of P. machaon. The study used 8…
Towards Teaching English for Pharmaceutical Purposes: An Attempt at a Description of Key Vocabulary and Phraseology in Clinical Trial Protocols and E…
2014
With the exception of medical schools or medical universities, English for Pharmaceutical Purposes is rarely taught as a specialist language course or ESP module at the university-level (e.g. designed specifically for training translators of specialist texts). This may be caused by, among other factors, the lack of comprehensive description of vocabulary and phraseology used across different pharmaceutical text types and genres, e.g. patient-pharmacist interactions, patient information leaflets, clinical trial protocols etc. This preliminary study is designed as an initial step to develop a description of vocabulary and phraseology, namely keywords, n-grams consisting of 4 words and phrase …
La dirección orquestal y su dimensión social: hacia la inclusión de la mujer
2022
Por influencia de las teorías freudianas suele decirse que, en el contexto de una orquesta, la batuta representa la virilidad, al ser un elemento usado única y exclusivamente por quien ostenta el liderazgo de aquella. El director, batuta en mano, se transforma en un mediador entre el conjunto musical, la obra y el público. Sin embargo, esta analogía únicamente funciona a nivel de recepción musical y social cuando estamos ante un líder varón. El presente artículo analiza con perspectiva de género el rol del director de orquesta partiendo de su origen, como figura que surge en el siglo XIX y evoluciona hasta la actualidad. En concreto se exponen los resultados de una investigación cuyo objeti…
eNOS S-nitrosylates β-actin on Cys374 and regulates PKC-θ at the immune synapse by impairing actin binding to profilin-1.
2017
The actin cytoskeleton coordinates the organization of signaling microclusters at the immune synapse (IS); however, the mechanisms involved remain poorly understood. We show here that nitric oxide (NO) generated by endothelial nitric oxide synthase (eNOS) controls the coalescence of protein kinase C-¿ (PKC-¿) at the central supramolecular activation cluster (c-SMAC) of the IS. eNOS translocated with the Golgi to the IS and partially colocalized with F-actin around the c-SMAC. This resulted in reduced actin polymerization and centripetal retrograde flow of ß-actin and PKC-¿ from the lamellipodium-like distal (d)-SMAC, promoting PKC-¿ activation. Furthermore, eNOS-derived NO S-nitrosylated ß-…
Optogenetically blocking sharp wave ripple events in sleep does not interfere with the formation of stable spatial representation in the CA1 area of …
2016
During hippocampal sharp wave/ripple (SWR) events, previously occurring, sensory inputdriven neuronal firing patterns are replayed. Such replay is thought to be important for plasticity-related processes and consolidation of memory traces. It has previously been shown that the electrical stimulation-induced disruption of SWR events interferes with learning in rodents in different experimental paradigms. On the other hand, the cognitive map theory posits that the plastic changes of the firing of hippocampal place cells constitute the electrophysiological counterpart of the spatial learning, observable at the behavioral level. Therefore, we tested whether intact SWR events occurring during th…