Search results for "types"
showing 10 items of 956 documents
A survey on features of allergic rhinitis in children
2013
Objective: A number of epidemiologic studies evaluated the prevalence of allergic rhinitis (AR), but few data are available on its different clinical presentations. We addressed this survey to assess the features of AR in children and adolescents. Methods: Thirty-five centers in Italy included 2623 pediatric patients with rhinitis, of whom 2319 suffered from AR, while 304 had other kinds of rhinitis. For each patient a standardized questionnaire was filled in, including ARIA classification, the duration of symptoms, the allergen identified as clinically relevant, the co-morbidities, the kind of treatment, the response to treatment, the satisfaction with the treatment, and the feasibility of…
The role of PNI to predict survival in advanced hepatocellular carcinoma treated with Sorafenib
2020
Background and aims The present study aims to investigate the role of the prognostic nutritional index (PNI) on survival in patients with advanced hepatocellular carcinoma (HCC) treated with sorafenib. Methods This multicentric study included a training cohort of 194 HCC patients and three external validation cohorts of 129, 76 and 265 HCC patients treated with Sorafenib, respectively. The PNI was calculated as follows: 10 × serum albumin (g/dL) + 0.005 × total lymphocyte count (per mm3). Univariate and multivariate analyses were performed to investigate the association between the covariates and the overall survival (OS). Results A PNI cut-off value of 31.3 was established using the ROC an…
Large-scale analysis of SARS-CoV-2 spike-glycoprotein mutants demonstrates the need for continuous screening of virus isolates
2021
Due to the widespread of the COVID-19 pandemic, the SARS-CoV-2 genome is evolving in diverse human populations. Several studies already reported different strains and an increase in the mutation rate. Particularly, mutations in SARS-CoV-2 spike-glycoprotein are of great interest as it mediates infection in human and recently approved mRNA vaccines are designed to induce immune responses against it. We analyzed 1,036,030 SARS-CoV-2 genome assemblies and 30,806 NGS datasets from GISAID and European Nucleotide Archive (ENA) focusing on non-synonymous mutations in the spike protein. Only around 2.5% of the samples contained the wild-type spike protein with no variation from the reference. Among…
Evolutionary plasticity of SH3 domain binding by Nef proteins of the HIV-1/SIVcpz lentiviral lineage
2021
The accessory protein Nef of human and simian immunodeficiency viruses (HIV and SIV) is an important pathogenicity factor known to interact with cellular protein kinases and other signaling proteins. A canonical SH3 domain binding motif in Nef is required for most of these interactions. For example, HIV-1 Nef activates the tyrosine kinase Hck by tightly binding to its SH3 domain. An archetypal contact between a negatively charged SH3 residue and a highly conserved arginine in Nef (Arg77) plays a key role here. Combining structural analyses with functional assays, we here show that Nef proteins have also developed a distinct structural strategy—termed the "R-clamp”—that favors the formation …
A NEURAL NETWORK PRIMER
1994
Neural networks are composed of basic units somewhat analogous to neurons. These units are linked to each other by connections whose strength is modifiable as a result of a learning process or algorithm. Each of these units integrates independently (in paral lel) the information provided by its synapses in order to evaluate its state of activation. The unit response is then a linear or nonlinear function of its activation. Linear algebra concepts are used, in general, to analyze linear units, with eigenvectors and eigenvalues being the core concepts involved. This analysis makes clear the strong similarity between linear neural networks and the general linear model developed by statisticia…
α1-Adrenoceptors in the rat cerebral cortex: New insights into the characterization of α1L- and α1D-adrenoceptors
2010
36 p., figuras y tablas, bibliografía
Phrase frames in English pharmaceutical discourse a corpus-driven study of intradisciplinary register variation
2015
Focusing on the exploration of intra-disciplinary register variation in the pharmaceutical domain, this corpus-driven study attempts to describe the use, composition and discourse functions of phrase frames, that is, contiguous sequences of words identical except for one (Fletcher, 2002-2007), found in samples of four English pharmaceutical text types, such as patient information leaflets, summaries of product characteristics, clinical trial protocols and chapters/sections from academic textbooks on pharmacology. The study deals with a specific sub-type of phrase frames, that is, 4-word units with a variable slot in the medial position, e.g. be * with caution, to take * medicine. The result…
Keywords and lexical bundles within English pharmaceutical discourse: A corpus-driven description
2015
Abstract Little attention has been paid so far to keywords and lexical bundles used in the English language typical of the pharmaceutical field. Conducted from a register-perspective (Biber & Conrad, 2009), this exploratory and descriptive research is intended to fill in the gap in corpus linguistics studies on phraseology and register variation within written English pharmaceutical discourse. More specifically, this empirical study presents a corpus-driven description of the use and functions of keywords (top-50 by keyness) complemented by a similar description of lexical bundles (top-50 by frequency) used across samples of patient information leaflets, summaries of product characteristics…
Is there a formula for formulaic language?
2015
AbstractThis paper focuses on detecting and measuring traces of "formulaic language". For this purpose, we test a number of computational formulae that quantify the degree to which a text type incorporates inflexible sequences of words. We assess these candidate indices using a number of reference corpora representing a wide variety of text types, both routine and creative. We adopt the concept of "phrase-frame" proposed by Fletcher (2002–2007) as a means of exploring phraseological pattern variability. To date, there have been few studies explicitly addressing this issue, with the exception of Roemer (2010). We examine ten productivity indices, including Roemer's VPR, the Herfindahl-Hirsch…
Register Variation Across English Pharmaceutical Texts: A Corpus-driven Study of Keywords, Lexical Bundles and Phrase Frames in Patient Information L…
2013
Abstract This study constitutes an initial step towards filling a gap in corpus linguistics studies of linguistic and phraseological variation across English pharmaceutical texts, in particular in terms of recurrent linguistic patterns. The study conducted from a register- perspective ( Biber & Conrad, 2009 ), which employs both quantitative and qualitative research procedures, aims to provide a corpus-driven description of vocabulary and phraseology, namely key words, lexical bundles, and phrase frames, used in patient information leaflets and summaries of product characteristics (represented by 463 and 146 texts, respectively) written originally in English and collected in two domain-spec…