Search results for "types"
showing 10 items of 956 documents
Reviewing lymnaeid vectors of fascioliasis by ribosomal DNA sequence analyses.
2005
AbstractSnails of the family Lymnaeidae are of great parasitological importance due to the numerous helminth species they transmit, mainly trematodiases (such as fascioliasis) of considerable medical and veterinary impact. The present knowledge of the genetics and host–parasite relationships of this gastropod group is far from adequate. Fascioliasis is caused by two species, Fasciola hepatica and F. gigantica, which, as in the case of other trematodes, show a marked snail host specificity. Many lymnaeid species involved in fascioliasis transmission still show a confused systematic-taxonomic status. The need for tools to distinguish and characterize species and populations of lymnaeids is ev…
Autoimmunity to the p53 protein is a feature of systemic lupus erythematosus (SLE) related to anti-DNA antibodies.
2001
The induction of anti-DNA autoantibodies in systemic lupus erythematosus (SLE) patients is problematic because mammalian DNA is poorly immunogenic at best. Here we demonstrate a chain of connected antibodies in SLE patient sera that could account for the induction of anti-DNA antibody, and possibly for some of the pathogenic features of SLE. We now report that SLE patients, in addition to anti-DNA, produce antibodies to the carboxy-terminal domain of the tumour suppressor molecule p53; this p53 domain recognizes damaged DNA. Hence, these anti-p53 antibodies could mimic damaged DNA immunologically. Indeed, SLE sera do contain anti-idiotypic antibodies to a prototypic anti-p53 antibody. Moreo…
Inflammation in Ischemic Stroke Subtypes
2011
Determining the cause of stroke does influence choices for management. categorization of subtypes of ischemic stroke has had considerable study, but definitions are hard to formulate and their application for diagnosis in an individual patient is often problematic. Cerebral ischemia initiates a complex cascade of events at genomic, molecular, and cellular levels, and inflammation is important in this cascade. In 1993 for For the Trial of Org 10172 in Acute Stroke Treatment (TOAST), Adams et al] conducted a placebo-controlled, randomized, blinded study of the low-molecular-weight heparinoid given to patients within 24 hours after stroke and developed a system for diagnosis of subtype of isch…
SULLA FIABA E SULLA LETTERATURA PER L'INFANZIA A PROPOSITO DI ALCUNI LIBRI
2023
L’articolo riflette su alcune proposte critiche contenute nel recente volume Di cosa parlano i libri per bambini. La letteratura per l’infanzia come critica radicale di Giorgia Grilli, studiosa di letteratura per l’infanzia da molti anni e traduttrice di classici della critica e della narrativa per ragazzi. Attingendo alle scienze cognitive, agli studi di antropologia, di psicologia degli archetipi, di filosofia e alla tradizione critica di settore, Grilli si interroga sul vero significato delle storie per bambini, sulla dimensione profondamente filosofica che alcuni classici per l’infanzia possiedono per dimostrare la complessità letteraria e antropologica di un ambito letterario ingiustam…
Ambiente e diritto penale: brevi riflessioni fra le modifiche agli artt.9 e 41 Cost. e le prospettive di riforma in ambito internazionale
2023
l contributo analizza l’impatto che il recente inserimento dell’ambiente in Costituzione può dispiegare in ambito penale, tanto rispetto all’ambiente quale oggetto della tutela penale, quanto sul versante della selezione dei modelli di illecito, soffermandosi in particolare sul problema delle possibili ricadute penalistiche del nuovo vincolo di solidarietà ecologica di tipo intergenerazionale. Seguendo il fil rouge del bene giuridico, la seconda parte del saggio ricostruisce invece i punti critici e le prospettive di sviluppo del diritto penale ambientale internazionale, alla luce della nozione di ambiente quale bene giuridico comune ed universale.
The computational power of continuous time neural networks
1997
We investigate the computational power of continuous-time neural networks with Hopfield-type units. We prove that polynomial-size networks with saturated-linear response functions are at least as powerful as polynomially space-bounded Turing machines.
Tiešsaistes Klientu Segmentācija, Izmantojot Klasterizācijas Metodes
2021
Bakalaura darba mērķis ir izpētīt tiešsaistes klientu segmentāciju, lai tā palīdzētu pieņemt loģiskus lēmumus par efektīvu mārketinga un reklāmas resursu izmantošanu. Darbā tika izmantotas divas klasterizācijas metodes: K-Medoīdu (K-Medoids) klasterizācija, un K-Prototipu (K-Prototypes) klasterizācija. Metožu izvēle tiek pamatota ar pētītā uzdevuma raksturojumu. Darba gaitā tiek aprakstīti gan abu metožu teorētiskie aspekti, gan metodes tiek pielietotas praktiski (izmantojot programmu R) konkrēta uzdevuma risināšanai. Tika veikta iegūto rezultātu analīze un salīdzināšana. Bakalaura darbā tika arī paskaidrota klientu segmentācijas nozīme veiksmīgam uzņēmumam, kā arī tika aprakstīts interneta…
Tracing European Founder Lineages in the Near Eastern mtDNA Pool
2000
Founder analysis is a method for analysis of nonrecombining DNA sequence data, with the aim of identification and dating of migrations into new territory. The method picks out founder sequence types in potential source populations and dates lineage clusters deriving from them in the settlement zone of interest. Here, using mtDNA, we apply the approach to the colonization of Europe, to estimate the proportion of modern lineages whose ancestors arrived during each major phase of settlement. To estimate the Palaeolithic and Neolithic contributions to European mtDNA diversity more accurately than was previously achievable, we have now extended the Near Eastern, European, and northern-Caucasus d…
Blood Component Therapy and Coagulopathy in Trauma: A Systematic Review of the Literature from the Trauma Update Group
2016
Background Traumatic coagulopathy is thought to increase mortality and its treatment to reduce preventable deaths. However, there is still uncertainty in this field, and available literature results may have been overestimated. Methods We searched the MEDLINE database using the PubMed platform. We formulated four queries investigating the prognostic weight of traumatic coagulopathy defined according to conventional laboratory testing, and the effectiveness in reducing mortality of three different treatments aimed at contrasting coagulopathy (high fresh frozen plasma/packed red blood cells ratios, fibrinogen, and tranexamic acid administration). Randomized controlled trials were selected alo…
Rapid nucleus-scale reorganization of chromatin in neurons enables transcriptional adaptation for memory consolidation
2020
AbstractThe interphase nucleus is functionally organized in active and repressed territories defining the transcriptional status of the cell. However, it remains poorly understood how the nuclear architecture of neurons adapts in response to behaviorally relevant stimuli that trigger fast alterations in gene expression patterns. Imaging of fluorescently tagged nucleosomes revealed that pharmacological manipulation of neuronal activity in vitro and auditory cued fear conditioning in vivo induce nucleus-scale restructuring of chromatin within minutes. Furthermore, the acquisition of auditory fear memory is impaired after infusion of a drug into auditory cortex which blocks chromatin reorganiz…