Search results for "uci"

Assessing the quality of studies in meta-research: Review/guidelines on the most important quality assessment tools

2020

Systematic reviews and meta-analyses pool data from individual studies to generate a higher level of evidence to be evaluated by guidelines. These reviews ultimately guide clinicians and stakeholders in health-related decisions. However, the informativeness and quality of evidence synthesis inherently depend on the quality of what has been pooled into meta-research projects. Moreover, beyond the quality of included individual studies, only a methodologically correct process, in relation to systematic reviews and meta-analyses themselves, can produce a reliable and valid evidence synthesis. Hence, quality of meta-research projects also affects evidence synthesis reliability. In this overview…

Olley–Pakes productivity decomposition: computation and inference

2016

Summary We show how a moment-based estimation procedure can be used to compute point estimates and standard errors for the two components of the widely used Olley–Pakes decomposition of aggregate (weighted average) productivity. When applied to business level microdata, the procedure allows for autocovariance and heteroscedasticity robust inference and hypothesis testing about, for example, the coevolution of the productivity components in different groups of firms. We provide an application to Finnish firm level data and find that formal statistical inference casts doubt on the conclusions that one might draw on the basis of a visual inspection of the components of the decomposition.

Effects of record linkage errors on registry-based follow-up studies

1997

The importance of reliable record linkage for high quality-population-based disease registration is widely recognized. Systematic methodologic work is lacking, however, on the effects of record linkage errors on the use of disease registries for epidemiologic purposes. The present paper provides algebraic models describing the effects of record linkage errors on monitoring survival of registered patients, which is commonly performed by matching registry records against a database of death certificates, and on registry-based incidence follow-up of external cohorts. Homonym errors, that is, erroneous linkage of records that pertain to distinct individuals, lead to underestimation of survival …

Statistical inference as a decision problem: the choice of sample size

1997

Global stability of protein folding from an empirical free energy function

2013

The principles governing protein folding stand as one of the biggest challenges of Biophysics. Modeling the global stability of proteins and predicting their tertiary structure are hard tasks, due in part to the variety and large number of forces involved and the difficulties to describe them with sufficient accuracy. We have developed a fast, physics-based empirical potential, intended to be used in global structure prediction methods. This model considers four main contributions: Two entropic factors, the hydrophobic effect and configurational entropy, and two terms resulting from a decomposition of close-packing interactions, namely the balance of the dispersive interactions of folded an…

Cocaine addiction and personality: a mathematical model.

2010

The existence of a close relation between personality and drug consumption is recognized, but the corresponding causal connection is not well known. Neither is it well known whether personality exercises an influence predominantly at the beginning and development of addiction, nor whether drug consumption produces changes in personality. This paper presents a dynamic mathematical model of personality and addiction based on the unique personality trait theory (UPTT) and the general modelling methodology. This model attempts to integrate personality, the acute effect of drugs, and addiction. The UPTT states the existence of a unique trait of personality called extraversion, understood as a di…

A note on alternative parameterizations of a model for evaluating agreement between two tests.

2004

The agreement between two competing tests which purport to measure the same trait is a common concern in test development. In this paper three alternative parameterizations of the measurement model useful in this context are presented. Both one-factor and two-factor approaches are applied. Lord's classic example, where the main problem is to investigate whether time limits represent an extra speed component in a vocabulary test, is used to illustrate the ideas.

Reference Posterior Distributions for Bayesian Inference

1979

Gaia DR2 reveals a star formation burst in the disc 2-3 Gyr ago

2019

We use Gaia DR2 magnitudes, colours and parallaxes for stars with G<12 to explore a 15-dimensional space that includes simultaneously the initial mass function (IMF) and a non-parametric star formation history (SFH) for the Galactic disc. This inference is performed by combining the Besancon Galaxy Model fast approximate simulations (BGM FASt) and an approximate Bayesian computation algorithm. We find in Gaia DR2 data an imprint of a star formation burst 2-3 Gyr ago, in the Galactic thin disc domain, and a present star formation rate (SFR) of about 1 Msun. Our results show a decreasing trend of the SFR from 9-10 Gyr to 6-7 Gyr ago. This is consistent with the cosmological star formation …

Individual stereoisomers of phosphinic dipeptide inhibitor of leucine aminopeptidase

2008

Abstract Individual stereoisomers of the phosphinic pseudodipeptide hPheψ[P(O)(OH)CH2]Phe were obtained by stereoselective liquid chromatographic separation as N- and C-terminally protected derivative on quinidine carbamate modified silica stationary phase. The stereoisomeric purity, exceeding 95% for each fraction, was determined before and after deprotection using two independent methods. The absolute configuration was rationally assigned by application of enantiomerically pure phosphinic acid substrates in the synthetic procedure and correlation with biological activity of the products. Substantial differences in inhibition of leucine aminopeptidase by the individual isomers revealed nov…