Search results for "uci"
showing 10 items of 5317 documents
Towards a fully synthetic MUC1-based anticancer vaccine: efficient conjugation of glycopeptides with mono-, di-, and tetravalent lipopeptides using c…
2011
Abstract The membrane-bound tumor-associated glycoprotein MUC1 is aberrantly glycosylated in cancer cells compared with normal cells, and is therefore considered an attractive target for cancer immunotherapy. However, tumor-associated glycopeptides from MUC1 do not elicit a sufficiently robust immune response. Therefore, antitumor vaccines were developed, which consist of MUC1 glycopeptides as the B epitopes and immune-stimulating toll-like receptor 2 (TLR 2) lipopeptide ligands. These fully synthetic vaccine candidates were prepared by solid-phase synthesis of the MUC1 glycopeptides. The Pam(3) Cys lipopeptide, also synthesized on solid-phase, was C-terminally coupled to oligovalent lysine…
Water-Soluble Polymers Coupled with Glycopeptide Antigens and T-Cell Epitopes as Potential Antitumor Vaccines
2013
Highly decorated: Tumor-associated MUC1 glycopeptide and tetanus toxoid T-cell epitope P2 can be attached to water-soluble poly(N-(2-hydroxypropyl)methacrylamide) carriers by orthogonal ligation techniques. Fully synthetic vaccine A with additional nanostructure-promoting domains induced antibodies that exhibit high affinity to tumor cells.
A fully synthetic vaccine consisting of a tumor-associated glycopeptide antigen and a T-cell epitope for the induction of a highly specific humoral i…
2005
A Synthetic Vaccine Consisting of a Tumor-Associated Sialyl-TN-MUC1 Tandem-Repeat Glycopeptide and Tetanus Toxoid: Induction of a Strong and Highly S…
2009
Palermo e Santa Lucia siracusana
2014
Nella Sicilia paleocristiana, il culto della martire dioclezianea Loukìa conosce una notevole fortuna nei primi secoli del Cristianesimo, tanto da varcare i confini dell’Isola e da estendersi nel Mediterraneo occidentale e orientale; molto si deve, in questo senso, all’opera pastorale dei pontefici, sin dalla fine del secolo IV. Anche Palermo partecipò della promozione del culto della martire, come attesta la fondazione gregoriana di un cenobio latino dedicato ai santi Agata e Massimo in Lucuscanum; è ben nota, infatti, la connessione tra le due sante Lucia e Agata, testimoniata non solo dai ben noti luoghi dei testi agiografici, ma anche dalle innovazioni nella liturgia introdotte dal papa…
An identifiable model to assess frequency-domain Granger causality in the presence of significant instantaneous interactions
2010
We present a new approach for the investigation of Granger causality in the frequency domain by means of the partial directed coherence (PDC). The approach is based on the utilization of an extended multivariate autoregressive (MVAR) model, including instantaneous effects in addition to the lagged effects traditionally studied, to fit the observed multiple time series prior to PDC computation. Model identification is performed combining standard MVAR coefficient estimation with a recent technique for instantaneous causal modeling based on independent component analysis. The approach is first validated on simulated MVAR processes showing that, in the presence of instantaneous effects, only t…
Ex Iani Gruteri in L. Senecam animadversionibus excerpta quaedam notatu digniora, et ab aliis nondum explicata
Caplletres ornades
Synergistic activation of dendritic cells by combined Toll-like receptor ligation induces superior CTL responses in vivo.
2006
Toll-like receptors (TLRs) are able to interact with pathogen-derived products and their signals induce the coordinated activation of innate and adaptive immune mechanisms. Dendritic cells (DCs) play a central role in these events. As the different TLRs are able to trigger MyD88/TRIF-dependent and -independent signaling pathways, we wondered if the simultaneous activation of these signaling cascades would synergize with respect to DC activation and induce superior cytotoxic T-lymphocyte (CTL) activity in vivo. We observed that indeed the combined activation of MyD88-dependent and -independent signaling induced by TLR7 and TLR3 ligands provoked a more rapid and more sustained bone marrow–der…
Promoter and exon–intron structure of the protein kinase C gene from the marine sponge Geodia cydonium: evolutionary considerations and promoter acti…
1999
Abstract We report the gene structure of a key signaling molecule from a marine sponge, Geodia cydonium. The selected gene, which codes for a classical protein kinase C (cPKC), comprises 13 exons and 12 introns; the introns are, in contrast to those found in cPKC from higher Metazoa, small in size ranging from 93 nt to 359 nt. The complete gene has a length of 4229 nt and contains exons which encode the characteristic putative regulatory and catalytic domains of metazoan cPKCs. While in the regulatory domain only one intron is in phase 0, in the catalytic domain most introns are phase 0 introns, suggesting that the latter only rarely undergo module duplication. The 5′-flanking sequence of t…
Desarrollo de las habilidades de expresión del alumnado de Derecho constitucional
2021
El Derecho constitucional presenta una serie de características que permiten una mayor amplitud en sus modos de enseñanza. De entre todas las posibilidades relativas a la innovación docente, abogamos por la inserción de unos elementos que permiten una enseñanza óptima de la materia. En concreto, destacamos el uso de las nuevas tecnologías, afianzadas por métodos tradicionales como incentivar la lectura, la escritura y la generación de debates sobre la materia. Todo ello con el objetivo de reforzar las habilidades de expresión del alumnado de derecho, por lo que la inserción de esas herramientas docentes conducirá a una mejora en la formación de los alumnos. Sobre todo, con las oportunidades…