Search results for "uci"
showing 10 items of 5317 documents
cIAP1-dependent TRAF2 degradation regulates the differentiation of monocytes into macrophages and their response to CD40 ligand.
2008
AbstractPeripheral blood monocytes are plastic cells that migrate to tissues and differentiate into various cell types, including macrophages, dendritic cells, and osteoclasts. We have described the migration of cellular inhibitor of apoptosis protein 1 (cIAP1), a member of the IAP family of proteins, from the nucleus to the Golgi apparatus in monocytes undergoing differentiation into macrophages. Here we show that, once in the cytoplasm, cIAP1 is involved in the degradation of the adaptor protein tumor necrosis factor receptor–associated factor 2 (TRAF2) by the proteosomal machinery. Inhibition of cIAP1 prevents the decrease in TRAF2 expression that characterizes macrophage formation. We d…
Kti12, a PSTK-like tRNA dependent ATPase essential for tRNA modification by Elongator
2019
Abstract Posttranscriptional RNA modifications occur in all domains of life. Modifications of anticodon bases are of particular importance for ribosomal decoding and proteome homeostasis. The Elongator complex modifies uridines in the wobble position and is highly conserved in eukaryotes. Despite recent insights into Elongator's architecture, the structure and function of its regulatory factor Kti12 have remained elusive. Here, we present the crystal structure of Kti12′s nucleotide hydrolase domain trapped in a transition state of ATP hydrolysis. The structure reveals striking similarities to an O-phosphoseryl-tRNA kinase involved in the selenocysteine pathway. Both proteins employ similar …
Creatividad en alumnos de talento matemático
2019
En el presente trabajo hacemos un estudio exploratorio en el que pretendemos medir la creatividad en relación con el talento matemático, basándonos en los trabajos de Roza Leikin (con su permiso). Seleccionamos dos muestras de alumnos, una formada por estudiantes de entre 15 y 17 años participantes en el programa ESTALMAT (dirigido a estudiantes con talento matemático), y la otra formada por alumnos del máster, con una sólida formación matemática. A cada participante, le pasamos un test con 4 problemas de matemáticas que son tareas de resolución múltiple, y les pedimos que den tantas soluciones como puedan de cada uno en un cierto límite de tiempo. Después, analizamos los resultados, tanto …
Binding properties and stability of the Ras-association domain of Rap1-GTP interacting adapter molecule (RIAM).
2012
The Rap1-GTP interacting adapter protein (RIAM) is an important protein in Rap1-mediated integrin activation. By binding to both Rap1 GTPase and talin, RIAM recruits talin to the cell membrane, thus facilitating talin-dependent integrin activation. In this article, we studied the role of the RIAM Ras-association (RA) and pleckstrin-homology (PH) domains in the interaction with Rap1. We found that the RA domain was sufficient for GTP-dependent interaction with Rap1B, and the addition of the PH domain did not change the binding affinity. We also detected GTP-independent interaction of Rap1B with the N-terminus of RIAM. In addition, we found that the PH domain stabilized the RA domain both in …
Cultural clashes in the lives of fictional Chinese American daughters : a study of selected novels by Maxine Hong Kingston and Amy Tan
1997
Effect of Opuntia ficus-indica Mucilage Edible Coating in Combination with Ascorbic Acid, on Strawberry Fruit Quality during Cold Storage
2021
Strawberry fruit is a nonclimacteric fruit and is one of the most consumed berries in the world. It is characterized by high levels of vitamin C, folate, vitamin E, β-carotene, and phenolic constituents as well asanthocyanins that are strictly related to health benefits. Strawberries are highly perishable fruit with a very short postharvest life due to their susceptibility to mechanical injury, rapid texture softening, physiological disorders, and infection caused by several pathogens (yeast and mold) that can rapidly reduce fruit quality. The aim of the present study was to evaluate the effect of the application of Opuntia ficus-indica mucilage in combination with ascorbic acid, as edible …
Especialidades contempladas en la legislación española respecto de la ejecución de la deuda tributaria en los delitos contra la Hacienda Pública
2020
Este es el documento final publicado que se encuentra de forma definitiva en la siguiente URL: https://www.revista-rbd.com/wp-content/uploads/2020/02/12._Antonio_Ferrer_pp._370-391.pdf En el tratamiento del delito fiscal, el procedimiento penal podía determinar la paralización de cualquier acción de la Hacienda Pública en orden al cobro de la deuda tributaria, lo que al margen de generar la idea errónea de que esta deuda se integraba estrictamente en el ámbito de la responsabilidad civil derivada del delito, dificultaba su ejecución determinando un importante agravio comparativo respecto al mero infractor, e incluso frente a un deudor ordinario, adoptándose por ello en nuestra legislación u…
Indicadors de Dinàmica
2019
Conjunt de fulls de càlcul dissenyats amb Microsoft Excel (versió 2003) que permeten calcular, per a diferents zones geogràfiques, els principals indicadors de dinámica de la població. Les dades necessàries per a aquest càlcul són: •Data de referència dels registres de població •Població en les zones geogràfiques estudiades
Day-to-Day Variability and Year-to-Year Reproducibility of Accelerometer-Measured Free-Living Sit-to-Stand Transitions Volume and Intensity among Com…
2021
(1) Background: The purpose of this study was to evaluate the day-to-day variability and year-to-year reproducibility of an accelerometer-based algorithm for sit-to-stand (STS) transitions in a free-living environment among community-dwelling older adults. (2) Methods: Free-living thigh-worn accelerometry was recorded for three to seven days in 86 (women n = 55) community-dwelling older adults, on two occasions separated by one year, to evaluate the long-term consistency of free-living behavior. (3) Results: Year-to-year intraclass correlation coefficients (ICC) for the number of STS transitions were 0.79 (95% confidence interval, 0.70-0.86, p < 0.001), for mean angular velocity-0.81 (95% c…
Oxidation State and Local Structure of Chromium Ions in LaOCl
2021
This research is funded by the Latvian Council of Science, project “Novel transparent nanocomposite oxyfluoride materials for optical applications”, project No. LZP-2018/1-0335. Institute of Solid State Physics, University of Latvia as the Center of Excellence has received funding from the European Union’s Horizon 2020 Framework Programme H2020-WIDESPREAD-01-2016-2017- TeamingPhase2 under grant agreement No. 739508, project CAMART2.