Search results for "uci"

showing 10 items of 5317 documents

Evaluation of anti-androgenic activity of di-(2-ethylhexyl)phthalate

2005

International audience; DEHP is a widely used platiciser in the manufacture of PVC-based materials. It is known to disrupt the reproductive tract development in male rats. We have performed the Hershberger assay with DEHP on an immature castrated rat model to check if DEHP antagonise the testosterone propionate androgenic effect on the accessory sex organs development. DEHP significantly decreased the BC/LA muscles, the prostate, and the seminal vesicles relative weights from 100, 200, and 400 mg/kg bw/day, respectively. DEHP increased the liver relative weight from 100 mg/kg bw/day. A study was also performed on MDA-MB453 cell line stably transfected with pMMTVneo-Luc with DEHP and its maj…

Testosterone propionateMalemedicine.medical_specialtyendocrine systemMDA-MB453 TRANSFECTED CELL LINEmedicine.drug_classMetabolitePhthalic AcidsMONO-(2-ETHYLHEXYL1)PHTHALATE010501 environmental sciencesGenitalia MaleToxicologyAntiandrogen01 natural sciences03 medical and health scienceschemistry.chemical_compoundProstatePlasticizersInternal medicineCell Line TumorDiethylhexyl PhthalatemedicineAnimalsRats WistarLuciferases030304 developmental biology0105 earth and related environmental sciences0303 health sciencesDose-Response Relationship DrugPhthalateMONO-(2-ETHYL-5-HYDROXYLHEXYL)PHTHALATEBiological activityAndrogen AntagonistsDihydrotestosteroneDrug SynergismOrgan SizeMETABOLITES MONO-(2-ETHYL-5-OXOHEXYL1)PHTHALATEIn vitroRatsTestosterone PropionateEndocrinologymedicine.anatomical_structurechemistryLiverCell culture[SDV.TOX]Life Sciences [q-bio]/ToxicologyHERSHBERGER ASSAYDI-(2-ETHYLHEXYL1)PHTHALATEOrchiectomy
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Accuracy and Completeness of Drug Information in Wikipedia: A Comparison with Standard Textbooks of Pharmacology

2014

The online resource Wikipedia is increasingly used by students for knowledge acquisition and learning. However, the lack of a formal editorial review and the heterogeneous expertise of contributors often results in skepticism by educators whether Wikipedia should be recommended to students as an information source. In this study we systematically analyzed the accuracy and completeness of drug information in the German and English language versions of Wikipedia in comparison to standard textbooks of pharmacology. In addition, references, revision history and readability were evaluated. Analysis of readability was performed using the Amstad readability index and the Erste Wiener Sachtextforme…

Textbooks as TopicInformation DisseminationMEDLINESocial Scienceslcsh:Medicine-PharmacologyEducationGermanSociologyMedizinische FakultätGermanyHumansMedicineTextbooks as TopicMass Mediaddc:610lcsh:ScienceLanguageInternetTextbooksMultidisciplinaryConsumer Health InformationInformation Disseminationbusiness.industrylcsh:RReproducibility of ResultsOnline EncyclopediasKnowledge acquisitionCommunicationsReadabilitylanguage.human_languageTeaching MethodsIndex (publishing)Drug Information ServicesPharmacology ClinicallanguageInformation sourceEncyclopediaslcsh:QbusinessResearch ArticlePLoS ONE
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DECORIN EFFECTS ON PROTEOMIC PROFILING OF BREAST CANCER CELLS: AN UPDATED STUDY

2015

The malignant carcinomas are characterized by several capabilities acquired by the neoplastic cells, among which the ability to invade the extracellular matrix (ECM) and to establish a crosstalk with several ECM components. Under this respect, the extracellular microenvironment is an entity extraordinarily rich of information with opposite signals. Our group has long undertaken the study of the effects of ECM molecules on the behavior of cancer cells in vitro. Among the studied molecules, the decorin was found to exert a non-permissive effect on the growth and motility of the transfected tumor cells. The decorin, belongs to the family of small leucine-rich proteoglycans (SLRP) and is involv…

The malignant carcinomas are characterized by several capabilities acquired by the neoplastic cells among which the ability to invade the extracellular matrix (ECM) and to establish a crosstalk with several ECM components. Under this respect the extracellular microenvironment is an entity extraordinarily rich of information with opposite signals. Our group has long undertaken the study of the effects of ECM molecules on the behavior of cancer cells in vitro. Among the studied molecules the decorin was found to exert a non-permissive effect on the growth and motility of the transfected tumor cells. The decorin belongs to the family of small leucine-rich proteoglycans (SLRP) and is involved physiologically in the fibrillogenesis of collagen. In the last few year a new anti-oncogenic role has been proposed for decorin1. This study aimed to implement the knowledge on the effects of ectopic decorin on breast cancer cells using as a reference point the results already achieved by our research group2 on the experimental model format. By breast cancer cell line 8701-BC and its transfected clone DEC-C2. The extension of the proteomic analysis combined with the mass spectrometry allowed to triplicate the number of identified proteins in our model. Among the newly identified proteins were members of the classes of metabolic enzymes S100 family and cell motility proteins which revealed a net decrease in the decorin transfected cells. Of considerable importance is the observation that these classes of proteins are the most involved in metastatic progression. These results confirm and reinforce the anti-oncogenic role hypothesized for decorin. The work was co-funded by the Italian 5x1000 to COBS.DECORIN
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Ceria-based electrolytes prepared by solution combustion synthesis: The role of fuel on the materials properties

2016

Ce0.8Sm0.2O2 − xpowders were synthesized by solution combustion synthesis using citric acid, cellulose and sucrose as single, or intimately mixed, fuels. The powders were characterized by X-ray diffraction, transmission electron microscopy, X-ray photoelectron spectroscopy, N2sorption at −196 °C, H2-temperature programmed reduction and thermogravimetric analyses. Textural properties of the powders were shaped by the peculiar employed fuel. The study of reducibility revealed that oxygen vacancies formation is mainly influenced by both parameters, specific surface area and total pore volume. The different tendency toward reduction played a key role in sintering under reducing atmosphe…

Thermogravimetric analysisMaterials scienceScanning electron microscopeInorganic chemistrySintering02 engineering and technology010402 general chemistry01 natural sciencesCatalysisCatalysiSpecific surface areaTemperature-programmed reductionSolution combustion synthesiGeneral Environmental ScienceIT-SOFC2300Reducing atmosphereProcess Chemistry and TechnologySamarium doped ceria021001 nanoscience & nanotechnologyMicrostructureSintering in reducing atmosphere0104 chemical sciencesDielectric spectroscopyIT-SOFC; Reducibility; Samarium doped ceria; Sintering in reducing atmosphere; Solution combustion synthesis; Catalysis; 2300; Process Chemistry and TechnologyChemical engineeringSolution combustion synthesisSettore CHIM/03 - Chimica Generale E Inorganica0210 nano-technologyReducibility
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Structural Characterisation of Complex Layered Double Hydroxides and TGA-GC-MS Study on Thermal Response and Carbonate Contamination in Nitrate- and …

2015

Layered double hydroxides (LDHs) are versatile materials used for intercalating bioactive molecules in the fields of pharmaceuticals, nutraceuticals and cosmetics, with the purpose of protecting them from degradation, enhancing their water solubility to increase bioavailability and improving their pharmacokinetic properties and formulation stability. Moreover, LDHs are used in various technological applications to improve stability and processability. The crystal chemistry of hydrotalcite-like compounds was investigated by X-ray powder diffraction (XRPD), automated electron diffraction tomography (ADT) and thermogravimetric analysis (TGA)-GC-MS to shed light on the mechanisms involved in io…

Thermogravimetric analysishydrotalcytethermal responseInorganic chemistryIntercalation (chemistry)intercationsion exchangeengineering.materialCatalysischemistry.chemical_compoundCrystallinityAdsorptionlayered compoundsOrganic chemistryTGAHydrotalciteIon exchangeChemistryOrganic Chemistryelectron diffraction; intercations; ion exchange; layered compounds; structure elucidationstructure elucidationLayered double hydroxidesstructural characterization hydrotalcyte TGA GC-MS thermal response X-ray powderGeneral ChemistryX-ray powderstructural characterizationengineeringCarbonateelectron diffractionGC-MS
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Thermal and hygrometric properties of traditional calcarenite stones in the area of Palermo

2017

Il contributo espone le misure di conducibilità termica svolte su tre conci di calcarenite conchiliare e la caratterizzazione igrometrica di uno di essi. I risultati sono confrontati con i dati termici e igrometrici riportati dalle norme tecniche esistenti (UNI 10351, UNI EN ISO 10456, UNI EN 1745). The energy improvement of historic buildings requires detailed knowledge of the thermal and hygrometric properties of traditional materials and components. These data should be collected for specific local contexts, where the features of historic constructions are comparable. For the purpose of developing this tool for the architectural heritage of Palermo, this research focuses on calcarenite s…

Thermophysical characterization calcarenite stone thermal conductivity water vapour resistance factor water absorption hygroscopic sorption drying curve porous material capillarity Palermobusiness.industry020209 energy0211 other engineering and technologiesSettore ICAR/10 - Architettura Tecnica02 engineering and technologyMasonryCivil engineeringCalcareniteCaratterizzazione termofisica calcarenite conducibilità termica proprietà igrometriche PalermoArchitectural heritage021105 building & construction0202 electrical engineering electronic engineering information engineeringbusinessGeology
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Tunable Structure and Properties of Segmented Thermoplastic Polyurethanes as a Function of Flexible Segment

2019

Segmented thermoplastic polyurethanes (PUs) were synthetized using macrodiols with different functional groups (carbonate, ester, and /or ether) as a segment with a molar mass of 1000 and 2000 g/mol, and 4,4&rsquo

ThermoplasticMaterials scienceSolucions polimèriquesPolymers and PlasticsMiscibilityArticlelcsh:QD241-441Thermoplastic polyurethaneDifferential scanning calorimetrylcsh:Organic chemistryUltimate tensile strengthmechanical and thermal properties.Shore durometermechanical and thermal propertiesPolycarbonateComposite materialdegradationchemistry.chemical_classificationTermoplàsticsGeneral ChemistryDynamic mechanical analysisCiència dels materialsthermoplastic polyurethanechemistryvisual_artvisual_art.visual_art_mediumflexible segmentphase segregationPolymers
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Il lavoro etero-organizzato prima e dopo il caso Foodora Italia.

2019

l contributo ripropone la discussione sull’esegesi della fattispecie disciplinata dall’art. 1 comma 2 del d. lgs. n. 81 del 2015 (nel testo anteriore alla riforma del 2019) trattata dall’autore nei Colloqui Giuridici sul Lavoro del 2015 (a cura) di Antonio Vallebona per il Massimario di Giurisprudenza del Lavoro. Lo studio rigettava la tesi che il lavoro organizzato dal committente fosse la terza fattispecie e anzi con riferimento delle condizioni di applicazio­ne dimostrava la necessità di una lettura includente. La conclusione era che la nuova disciplina aveva natura antifraudolenta e determinava un allargamento (relativo) dell’area della subordi­nazione conseguente alla riduzione del cam…

This article republishes (after the Italian Supreme Court judgement n.166/2020 on the Foodora Italia case) the contribution to the exegesis of the case brought by art. 1 para­graph 2 of the d. lgs. n. 81 of 2015 (in the text before the 2019 reform) delivered by the author in the 2015's "Colloqui Giuridici sul Lavoro" (edited) by Antonio Vallebona for the "Massimario di Giurisprudenza del Lavoro". The study rejected the thesis that the job organ­ised by the client was an intermediate regulation between the employee and the self-employed ones. Indeed regarding the conditions for its application it showed the need for extensive reading. The conclusion was that the new discipline was (and is) an anti-fraudulent one. It led to a (relative) expansion of the area ofsubordination as a consequence of a reduction in the scope of coordinated self-employed work. A little more than four years after that article the Italian Supreme Court (with the judgement n.166/2020) on the Foodora Italia case addresses for the first time the issue of the hetero-organised work (by art. 1 paragraph 2 of the d. lgs. n. 81 of 2015). The Supreme Court fully adheres to the paper's thesis. So in terms of the "re­medial" function of the standardthe nature of the organisation's specific conditionand eventually reducing the legal frame for coordinated work. The fact that the procedural matter dealt with the riders was (then and now is) utterly irrelevant for the correct interpretation of such a new provision. Giving to riders of the employee status is not an effect of the peculiarit­ies of the work through digital platforms. It is a consequence of the remedial nature of such a case-law.
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Synthesis of tumor-associated glycopeptide antigens for the development of tumor-selective vaccines

2004

In contrast to normal cells, the glycoprotein profile on epithelial tumor cells is distinctly altered. Due to an incomplete formation of the glycan side-chains resulting from a premature sialylation, additional peptide epitopes become accessible to the immune system in mucin-type glycoproteins on tumor cells. These tumor-associated structure alterations constitute the basis for a selective immunological attack on cancer cells. For the construction of immunostimulating antigens, glycopeptide partial structures from the mucins MUC1 and MUC4 carrying the tumor-associated sialyl-T(N), alpha2,6-sialyl-T and alpha2,3-sialyl-T antigens have been synthesized. Employing different linkers such as the…

ThreonineGlycanGeneral Chemical EngineeringT cellAsialoglycoproteinsOligosaccharidesCancer VaccinesBiochemistryEpitopeImmune systemAntigenMaterials ChemistrymedicineHumansCytotoxic T cellAntigens Tumor-Associated CarbohydrateNeoplasms Glandular and EpithelialMUC1biologyChemistryGlycopeptidesMucinsGeneral MedicineGeneral ChemistryGlycopeptidecarbohydrates (lipids)medicine.anatomical_structureBiochemistrySialic Acidsbiology.proteinImmunizationThe Chemical Record
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Biomimetic synthesis of the tumor-associated (2,3)-sialyl-T antigen and its incorporation into glycopeptide antigens from the mucins MUC1 and MUC4.

2004

Glycoproteins on epithelial tumor cells often exhibit aberrant glycosylation profiles. The incomplete formation of the glycan side chains resulting from a down-regulated glucosamine transfer and a premature sialylation results in additional peptide epitopes, which become accessible to the immune system in mucin-type glycoproteins. These cancer-specific structure alterations are considered to be a promising basis for selective immunological attack on tumor cells. Among the tumor-associated saccharide antigens, the (2,3)-sialyl-T antigen has been identified as the most abundant glycan, found in several different carcinoma cell lines. According to a linear biomimetic strategy, the (2,3)-sialyl…

ThreonineGlycanMagnetic Resonance SpectroscopyMolecular Sequence DataCancer VaccinesCatalysisEpitopeMass SpectrometryImmune systemAntigenAntigens NeoplasmBiomimeticsMUC1Chromatography High Pressure LiquidGlycoproteinschemistry.chemical_classificationbiologyMucin-4Organic ChemistryMucinMucin-1GlycopeptidesMucinsGeneral ChemistryGlycopeptidecarbohydrates (lipids)chemistryBiochemistryCarbohydrate SequenceTandem Repeat Sequencesbiology.proteinIndicators and ReagentsGlycoproteinChemistry (Weinheim an der Bergstrasse, Germany)
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