Search results for "uni"
showing 10 items of 37626 documents
Immune responses during COVID-19 infection
2020
International audience; Over the past 16 years, three coronaviruses (CoVs), severe acute respiratory syndrome CoV (SARS-CoV) in 2002, Middle East respiratory syndrome CoV (MERS-CoV) in 2012 and 2015, and SARS-CoV-2 in 2020, have been causing severe and fatal human epidemics. The unpredictability of coronavirus disease-19 (COVID-19) poses a major burden on health care and economic systems across the world. This is caused by the paucity of in-depth knowledge of the risk factors for severe COVID-19, insufficient diagnostic tools for the detection of SARS-CoV-2, as well as the absence of specific and effective drug treatments. While protective humoral and cellular immune responses are usually m…
Molecular Basis of SARS-CoV-2 Nsp1-Induced Immune Translational Shutdown as Revealed by All-Atom Simulations.
2021
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic represents the most severe global health crisis in modern human history. One of the major SARS-CoV-2 virulence factors is nonstructural protein 1 (Nsp1), which, outcompeting with the binding of host mRNA to the human ribosome, triggers a translation shutdown of the host immune system. Here, microsecond-long all-atom simulations of the C-terminal portion of the SARS-CoV-2/SARS-CoV Nsp1 in complex with the 40S ribosome disclose that SARS-CoV-2 Nsp1 has evolved from its SARS-CoV ortholog to more effectively hijack the ribosome by undergoing a critical switch of Q/E158 and E/Q159 residues that perfects Nsp1's interactions…
Why viruses sometimes disperse in groups?
2019
AbstractMany organisms disperse in groups, yet this process is understudied in viruses. Recent work, however, has uncovered different types of collective infectious units, all of which lead to the joint delivery of multiple viral genome copies to target cells, favoring co-infections. Collective spread of viruses can occur through widely different mechanisms, including virion aggregation driven by specific extracellular components, cloaking inside lipid vesicles, encasement in protein matrices, or binding to cell surfaces. Cell-to-cell viral spread, which allows the transmission of individual virions in a confined environment, is yet another mode of clustered virus dissemination. Nevertheles…
The Influence of the Lotus Flower Theme on the Perception Perception of Contemporary Urban Architecture
2021
We live in the visual culture times, when images continuously and daily are transferring some information. A visual message is also an indispensable element of architecture, in the semantic layer as an aesthetic value, sometimes fulfilling a narrative function by means of a symbol, which is an international visual code. Most of the symbols, hidden in painting, sculpture, or architecture, are elements of nature. The article discusses examples of architecture whose form is based on a lotus flower. Unification of urban landscapes leads to a decrease in the value of aesthetic impressions; therefore, the unique architecture builds the unique identity of the place.
Building a political image on Instagram: A study of the personal profile of Santiago Abascal (Vox) in 2018
2020
Due to Instagram’s growing popularity in Spain, politicians have also begun to turn to this social network increasingly more. Accordingly, this paper analyses the visual and textual discourse of 259 posts published throughout 2018 on the personal Instagram profile of Santiago Abascal, the leader of the party Vox. Insofar as he is the Spanish politician with the highest number of followers on Instagram, the aim here is to analyse how he uses this social network in order to identify possible strategies that justify his growing number of followers. In the analysis, special attention was paid to aspects that might have contributed to the (self)presentation of Abascal and the promotion of his pa…
视觉工作记忆存储的表征单位 [The Representation Unit of Visual Working Memory]
2022
The visual working memory is a limited storage system in which people could flexibly process the representations to complete the task. Among studies on the capacity of visual working memory, the representation unit is a prior subject. Previous research employs the change-detection paradigm and the recall paradigm to explore the nature of representations when features of diverse dimensions and different-level features of the same dimension are stored in the visual working memory. These studies elicit two binary hypotheses: the object-based representation hypothesis backs that those diverse features are bound on the object and form a whole, while the feature-based representation hypothesis su…
Når skjermene inntar kirkerommet - om bruk av digital presentasjonsteknikk i gudstjenester
2021
This study aims to elucidate how modern presentation technology is being used by Norwegian Christian congregations. It is based on a survey answered by 715 church leaders, and the practice revealed is discussed particularly on the basis of Eileen D. Crowley's framework for ‘liturgical media art’. The findings show that presentation technology is used to a significant extent, but mainly as practical, visual support for communication. The article argues that there is a potential to use technology for aesthetic purposes as well.
Giovani e musica: verso un'estetica sociale della musica
2007
In questo contributo si intende proporre una prima riflessione circa una pista di ricerca volta a definire i tratti teorici ed empirici di un’estetica sociale della musica. Si mira cioè a rintracciare e ricostruire una fenomenologia dei vissuti musicali a partire non tanto dalla domanda se e come la musica (intesa come significato e come testo) “esprima” o “rappresenti” il reale, quanto piuttosto dall’intento di accertare (attraverso una metodologia di tipo etnografico ed etnometodologico) se e come la musica possa essa stessa produrre la realtà, determinando certe forme e manifestazioni di azione sociale nel quotidiano. Ciò appare particolarmente significativo in un’epoca postmoderna e glo…
CSDD reklāmas kampaņas "Izkāp no telefona!" vēstījums un auditorijas viedokļu analīze
2022
Bakalaura darba tēma ir CSDD reklāmas kampaņas “Izkāp no telefona!” vēstījums un auditorijas viedokļu analīze". Bakalaura darba mērķis ir izpētīt reklāmas kampaņas “Izkāp no telefona” auditorijas viedokli par reklāmas vizuālo atainojumu un vēstījuma nodošanu. Pētnieciskie jautājumi – kā CSDD reklāmas kampaņu “Izkāp no telefona” vērtē auditorija, vai vizuālais atainojums reklāmas kampaņas auditorijai, palīdz saprast problēmas nopietnību un vai reklāmas kampaņas vēstījums nonāca līdz auditorijai un lika rīkoties. Teorētiskajā daļā tiks apskatīts, kas ir reklāma un reklāmas kampaņa, kas jāņem vērā, lai izplānotu un izveidotu reklāmas kampaņu, kā arī, kā saprast, kuros mediju kanālos publicēt š…
Vizuālā naratīva un intertekstuālo atsauču salīdzinājums Džima Džārmuša filmās "Patersons" un "Izdzīvo tikai mīlētāji"
2018
Bakalaura darbā Vizuālā naratīva un intertekstuālo atsauču salīdzinājums Džima Džārmuša filmās “Patersons” (2016) un “Izdzīvo Tikai Mīlētāji” (2013) pētītas un salīdzinātas intertekstuālās atsauces Džima Džārmuša filmās “Izdzīvo Tikai Mīlētāji” (2013) un “Patersons” (2016), kā arī pētīts kā šīs atsauces paskaidro filmu vēstījumu. Darba mērķis ir atrast un salīdzināt intertekstuālās atsauces Dž. Džārmuša filmās “Patersons” un “Izdzīvo Tikai Mīlētāji”, izprast kā tās skaidro naratīvu, kā arī analizēt un salīdzināt filmu vizuālo naratīvu. Pētījuma problēma skaidro kā intertekstuālās atsauces, kuras atrodamas filmās atklāj, paskaidro naratīva nozīmi. Uzdevumi ir meklēt un atlasīt nepieciešamos …