Search results for "units"
showing 10 items of 576 documents
Antimicrobial Lessons From a Large Observational Cohort on Intra-abdominal Infections in Intensive Care Units
2021
Severe intra-abdominal infection commonly requires intensive care. Mortality is high and is mainly determined by disease-specific characteristics, i.e. setting of infection onset, anatomical barrier disruption, and severity of disease expression. Recent observations revealed that antimicrobial resistance appears equally common in community-acquired and late-onset hospital-acquired infection. This challenges basic principles in anti-infective therapy guidelines, including the paradigm that pathogens involved in community-acquired infection are covered by standard empiric antimicrobial regimens, and second, the concept of nosocomial acquisition as the main driver for resistance involvement. I…
A Study on the Use of Combustion Phase Indicators for MBT Spark Timing on a Bi-Fuel Engine
2007
The performance of a spark ignition engine strongly depends on the phase of the combustion process with respect to piston motion, and hence on the spark advance; this fundamental parameter is actually controlled in open-loop by means of maps drawn up on the test bench and stored in the Electronic Control Unit (ECU). Bi-fuel engines (e.g. running either on gasoline or on natural gas) require a double mapping process in order to obtain a spark timing map for each of the fuels. This map based open-loop control however does not assure to run the engine always with the best spark timing, which can be influenced by many factors, like ambient condition of pressure, temperature and humidity, fuel p…
Is activated hemocyanin instead of phenoloxidase involved in immune response in woodlice?
2008
In the Common woodlouse Porcellio scaber (Crustacea: Isopoda: Oniscidea), experimental immune challenge did not induce the expression of pro-phenoloxidase that, in most other invertebrates studied thus far, can be activated into phenoloxidase via an activation cascade upon immune challenge. Instead, Porcellio hemocyanin proved to exhibit catecholoxidase activity upon activation. However, none of the activating factors known from other invertebrates other than SDS-treatment resulted in activation of hemocyanin into a functional phenoloxidase in vitro. The distinct characteristics of isopod hemocyanin are reflected by the quaternary structure of the hemocyanin dodecamers that differs from tha…
PROFESSIONAL AND MANAGERIAL COMPETENCIES ENHANCING ORGANIZATIONAL COMPETENCES OF EMERGENCY MEDICAL UNITS
2019
This article is focused on identifying within managers of Emergency Medical Units (EMU) the common professional competencies of medical personnel, as well as the managerial competencies that significantly shape such organizations. The proposed lists of managerial and professional competencies were created based on the analysis of healthcare competencies models as literature studies and own author’s observations in the analyzed entities. To capture the complexity and dynamic quality of the EMU manager’s role and reflect the dynamic realities in health leadership today, the managerial competencies model distinguishes five domains with 26 competencies, while the model of professional competenc…
Professional competencies in shaping the organizational competences of Polish Emergency Medical Units in the light of survey research
2021
Purpose: The aim of the article is to identify the current level of professional competencies and to determine the extent to which individual professional competencies affect the organizational competences of Emergency Medical Units in the areas of marketing (recognizing the patient's needs), quality (level of medical services) and logistics (provision of medical services in the right place and time). Design/methodology/approach: The model of professional competencies of medical staff employed in Polish EMU establishes eight domains. To achieve superior organizational performance is very important to identify which set of professional competencies is required to gain their strategic goals. …
THE INFLUENCE OF PERSONAL COMPETENCIES ON ORGANIZATIONAL COMPETENCES OF EMERGENCY MEDICAL UNITS
2022
Purpose: The aim of the article is to present organizational competences of Emergency Medical Units (EMU) in the areas of marketing (recognizing the patient's needs), quality (the level of medical services) and logistics (a provision of medical services in the right place) during the time of the COVID 19 pandemic, influenced by managerial and professional competencies, and to identify those that have become particularly important in the period of the pandemic. Design/methodology/approach: The proposed lists of managerial (five domains) and professional competencies (eight domains) were created and are based on the analysis of healthcare competencies models – the study of the literature – an…
Personal Competencies Enhancing Organizational Competences of Emergency Medical Units in Poland - Empirical Research
2018
In turbulent and often chaotic environments, healthcare organizations need to develop and nurture a unique set of resources. These sets are built into/out of skills and capabilities, often referred to as core competences. Competency identification systems need to identify both – personal (managerial and professional) competencies and organizational competences. This article is focused on identification of the common professional competencies of medical personnel and managerial competencies of managers significantly shaping organizational competences of Emergency Medical Units in Poland. There were constructed models of personal competencies – managerial and professional. The model of manage…
γ2-Adaptin, a Ubiquitin-interacting Adaptor, Is a Substrate to Coupled Ubiquitination by the Ubiquitin Ligase Nedd4 and Functions in the Endosomal Pa…
2008
gamma2-Adaptin is a putative member of the clathrin adaptor protein family with unknown physiological function. We previously reported that gamma2-adaptin acts as a ubiquitin receptor by virtue of its ubiquitin-interacting motif. Here we demonstrate that this motif mediates a specific physical interaction with the ubiquitin ligase Nedd4 and promotes ubiquitination of gamma2-adaptin. By mapping regions of Nedd4 involved in binding to gamma2-adaptin, we identified its C2 domain to be essential, whereas the WW and HECT domains are dispensable. Consistent with this, we uncovered that the C2 domain of Nedd4 is ubiquitinated itself and as such is recruited by the ubiquitin-interacting motif of ga…
γ2-Adaptin is functioning in the late endosomal sorting pathway and interacts with ESCRT-I and -III subunits.
2010
Abstractγ2-Adaptin is a clathrin adaptor-related protein with unclear physiological function. Previous studies indicated that γ2-adaptin might act within the multivesicular body (MVB) protein-sorting pathway that is central to receptor down-regulation, lysosome biogenesis, and budding of enveloped viruses. Here, we have analyzed the effects of excess and deficit γ2-adaptin on exogenous and endogenous MVB cargoes and on the MVB machinery itself. Foreign cargoes, like retroviral Gags, are entrapped by overexpressed γ2-adaptin in detergent-insoluble polymers and blocked in budding. When viral budding involves MVB/endosomal structures, excess γ2-adaptin acts by accelerating lysosomal Gag destru…
Trafficking of the human transferrin receptor in plant cells: effects of tyrphostin A23 and brefeldin A.
2006
Plant cells possess much of the molecular machinery necessary for receptor-mediated endocytosis (RME), but this process still awaits detailed characterization. In order to identify a reliable and well-characterized marker to investigate RME in plant cells, we have expressed the human transferrin receptor (hTfR) in Arabidopsis protoplasts. We have found that hTfR is mainly found in endosomal (Ara7- and FM4-64-positive) compartments, but also at the plasma membrane, where it mediates binding and internalization of its natural ligand transferrin (Tfn). Cell surface expression of hTfR increases upon treatment with tyrphostin A23, which inhibits the interaction between the YTRF endocytosis signa…