Search results for "unity"
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Highly protective in vivo function of cytomegalovirus IE1 epitope-specific memory CD8 T cells purified by T-cell receptor-based cell sorting.
2005
ABSTRACTReconstitution of antiviral CD8 T cells is essential for controlling cytomegalovirus (CMV) infection after bone marrow transplantation. Accordingly, polyclonal CD8 T cells derived from BALB/c mice infected with murine CMV protect immunocompromised adoptive transfer recipients against CMV disease. The protective population comprises CD8 T cells with T-cell receptors (TCRs) specific for defined and for as-yet-unknown viral epitopes, as well as a majority of nonprotective cells with unrelated specificities. Defined epitopes include IE1/m123 and m164, which are immunodominant in terms of the magnitude of the CD8 T-cell response, and a panel of subordinate epitopes (m04, m18, M45, M83, a…
Lymphoma cell apoptosis in the liver induced by distant murine cytomegalovirus infection.
2006
ABSTRACTCytomegalovirus (CMV) poses a threat to the therapy of hematopoietic malignancies by hematopoietic stem cell transplantation, but efficient reconstitution of antiviral immunity prevents CMV organ disease. Tumor relapse originating from a minimal residual leukemia poses another threat. Although a combination of risk factors was supposed to enhance the incidence and severity of transplantation-associated disease, a murine model of a liver-adapted B-cell lymphoma has previously shown a survival benefit and tumor growth inhibition by nonlethal subcutaneous infection with murine CMV. Here we have investigated the underlying antitumoral mechanism. Virus replication proved to be required, …
Interleukin-7 or Interleukin-15 Enhances Survival ofMycobacterium tuberculosis-Infected Mice
2000
ABSTRACTBoth antigen-presenting cells and immune effector cells are required to effectively eradicate or containMycobacterium tuberculosis-infected cells. A variety of cytokines are involved to ensure productive “cross talk” between macrophages and T lymphocytes. For instance, infection of macrophages with mycobacteria leads to effective interleukin-7 (IL-7) and IL-15 secretion, and both cytokines are able to maintain strong cellular immune responses of α/β and γ/δ T cells. Here we show that either cytokine is able to enhance survival ofM. tuberculosis-infected BALB/c mice significantly compared to application of IL-2, IL-4, or phosphate-buffered saline (as a control). Enhanced survival cou…
CD4+CD25+ Regulatory T Cells and TGF-Beta in Mucosal Inflammation
2008
Transforming growth factor-beta (TGF-beta) is an anti-inflammatory cytokine which plays a key role in the maintenance of the immune system homeostasis. Indeed the abrogation of the TGF-beta signaling in immune cells leads to autoimmunity and inflammation in several organs including the gut. TGF-beta acts at multiple levels to maintain the immune system in check. However, TGF-beta has been recently shown to play a key role in the peripheral generation and function of CD4+CD25+ regulatory T cells, a subset of suppressive lymphocytes involved in the control of effector T cell activation and proliferation. Consistently abrogation of Tregs maturation as observed in different systems leads to a p…
Natural and adoptive T-cell immunity against herpes family viruses after allogeneic hematopoietic stem cell transplantation.
2011
Reactivated infections with herpes family-related cytomegalovirus, Epstein–Barr virus and varicella zoster virus are serious and sometimes life-threatening complications for patients undergoing allogeneic hematopoietic stem cell transplantation. The pathogenesis of these infections critically involves the slow and inefficient recovery of antiviral T-cell immunity after transplantation. Although efficient drugs to decrease viral load during this vulnerable period have been developed, long-term control of herpes viruses and protection from associated diseases require the sufficient reconstitution of virus-specific memory T cells. To heal the deficiency by immunotherapeutic means, numerous re…
L’impegno educativo della fabbrica Olivetti nell’Italia del secondo dopoguerra. Storia di una comunità responsabile
2015
The Olivetti factory, founded in the 1930s, experienced a total transformation in the post-war period thanks to Adriano Olivetti, who, from 1946 to 1960, created an educational project for modernizing his enterprise and making it more international. Olivetti’s “concrete utopia” was constructed around the idea of a “community”, guiding the life of the factory towards a more conscious and responsible participation, by tending to blur the division between managers and workers and between working and private life. The signs of this corporate revolution were the cultural and social initiatives promoting the worker’s personal and professional development. The social services for children, women, …
Il ruolo della cultura nel progetto comunitario di Adriano Olivetti
2021
Adriano Olivetti (1901-1960) was the promoter of an unprecedented business project that not only concerned the economic sphere, but also included architecture, social development, politics, the value of the person and of the culture. This paper examines the educational role played by culture in the Olivetti’s project as a way of human growth. To clarify the identity of the Olivetti’s culture, various sources were questioned: the personal library, the editorial choices, his coworkers and the good educational practices carried out in the Olivetti factory. These are pieces of a mosaic through which was possible to reconstruct the Olivettian ideal of a culture that, placed at the center of its …
La Philosophy for Children and Community come pratica didattica e sostegno educativo alla genitorialità
2022
The aim of this paper is to present the curriculum of Philosophy for Children and highlight its pedagogical and didactic aspect. This method enhances the promotion of co-construction of thought thanks to the creation of a community of inquiry. At the heart of this methodology, there are the philosophical novels, which allows children to experiment with philosophical practices. These philo sophical novels (written by Lipman, author of the curriculum) present different themes and are aimed at specific age groups. The Philosophy for Children method has not been used only with chil dren, but it is now widely used in various contexts of adult educa tion, in the analogous form of the Philosophy f…
Angela Zucconi e il Centro di Educazione Professionale per assistenti sociali (1949-1963)
2016
In questo articolo viene ricostruito l’impegno educativo e sociale di Angela Zucconi che, negli anni del secondo dopoguerra, fu coinvolta dai coniugi Calogero nella direzione del Cepas (Centro di Educazione Professionale per Assistenti Sociali). La sua proposta pedagogica, orientata a realizzare un’educazione degli adulti civica e comunitaria, faceva dell’assistente sociale un educatore che doveva possedere la qualità di un maestro capace di destare gli altri a se stessi, affinché si facessero interpreti della società in vista della sua trasformazione in una democrazia partecipata dal basso. This paper retraces the educational and social commitment of Angela Zucconi that, in the post-war pe…
May Measurement Month 2018: an analysis of blood pressure screening results from Spain.
2020
Este artículo se encuentra disponible en la siguiente URL: https://academic.oup.com/eurheartjsupp/article/22/Supplement_H/H119/5898732 En este artículo también participan: Fernando Martínez, Blanca Carreras, Bettina de Berardinis, Thomas Beaney, Anca Chis Ster, Neil R. Poulter, Xin Xia y Luis M. Ruilope. Elevated blood pressure (BP) is the single most important contributing risk factor to the global disease burden, leading to over 10 million deaths each year. In Spain, hypertension (HTN) affects around 20% of the adult population and remains the greatest attributable cause of cardiovascular mortality. May Measurement Month (MMM) is a worldwide initiative aimed at increasing awareness of HTN…