Search results for "unity"
showing 10 items of 3852 documents
Fine-scale estimations of bioclimatic change in the Valencia region, Spain
2016
Recent advances in statistical downscaling have allowed the reconstruction of temperatures for the complete 1948–2011 period in a spatial resolution of 90 m and without gaps for the Valencian Community (Spain) and bordering areas. It presently enables analyses in this region, which allows the determination of recent temperature changes at subregional and local scales. The present work focuses on obtaining the thermicity index according to Rivas-Martínez, a well-known indicator of different thermotypes associated with bioclimatic horizons. The change in this index, which has happened in the region between 1948 and 2011, was calculated by generating fine-scale maps of the potential extension …
Assessing genetic structure and diversity of airborne bacterial communities by DNA fingerprinting and 16S rDNA clone library
2005
Abstract The density, genetic structure and diversity of airborne bacterial communities were assessed in the outdoor atmosphere. Two air samples were collected on the same location (north of France) at two dates (March 2003 (sample1) and May 2003 (sample 2)). Molecular culture-independent methods were used to characterise airborne bacterial communities regardless of the cell culturability. The automated-ribosomal intergenic spacer analysis (A-RISA) was performed to characterise the community structure in each sample. For both sampling dates, complex A-RISA patterns were observed suggesting a highly diverse community structure, comparable to those found in soil, water or sediment environment…
Weed communities of root crops in the Pamir Alai Mts, Tajikistan (Middle Asia)
2013
<p>The paper presents the results of investigations of weed vegetation conducted on root crops in Tajikistan (Middle Asia), one of the world cradles of weed flora. The main research was conducted in the Zeravshanian, southern Tajikistan and Hissar-Darvasian geobotanical regions in 2011. The study was based on 107 phytosociological relevés obtained in various geobotanical regions of the country. The collected material probably presents the majority of variations among the weed communities of root cultivations in the Middle Asia. As a result of numerical analyses, 7 associations were distinguished: <em>Convolvulo arvensis-Cyperetum rotundi</em>, <em>Daturo stramonii-Hi…
Anti-parietal cell antibodies – diagnostic significance
2015
Anti-parietal cell antibodies (APCA) are an advantageous tool for screening for autoimmune atrophic gastritis (AAG) and pernicious anemia (PA). The target for APCA is the H+/K+ ATP-ase. It has been demonstrated, that APCA target both, the alpha, and beta subunits of the proton pump, although the major antigen is the alpha subunit. Circulating serum APCA can be detected by means of immunofluorescence, enzyme-linked immunosorbent assay – currently the most commonly used method, and radioimmunoprecipitation assay (RIA) – the 4A subunit has been optimized as a molecularspecific antigen probe. RIA is the most accurate method of antibody assessment, characterized by highest sensitivity. APCA can …
The role of Aurora-A inhibitors in cancer therapy
2007
Recently, new chemotherapy agents which target the non-structural components of mitosis have been developed. An important protein involved in several mitotic phases is the Aurora-A protein. By means of the phosphorylation of different substrates, Aurora-A regulates the correct development of the various phases of mitosis. The kinase activity of this protein makes Aurora-A an excellent candidate as an oncogene. The first data of Aurora-A involvement in cancer regarded the identification of Aurora-A overexpression in primary breast and colon tumour samples. With regard to the predictive role of Aurora-A, it has been shown that its overexpression disrupts the spindle checkpoint activated by pa…
Análisis de los niveles de estrés en un grupo de maestros con alumnos diagnosticados con trastorno del espectro autista
2019
espanolObjetivo y metodo: se analiza si un grupo de maestros que tienen en el aula alumnos diagnosticados de trastornos del espectro del autismo (TEA) presentan un nivel mas elevado de estres que los que no los tienen. Los participantes (N=16) proceden de un centro publico de la Comunidad Valenciana. El instrumento utilizado es la Esca-la ED-6. Resultados: el estudio revela que los maestros que ensenan a ninos con TEA tienen un nivel de estres mayor que los maestros que trabajan con ninos sin necesidades especificas de apoyo educativo. Tambien se observan diferencias im-portantes en las variables de ansiedad, creencias y presiones. Conclusiones: tener discentes con TEA puede implicar tener …
Role of Hsp70 in Multiple Sclerosis: An Overview
2019
For many years heat shock protein 70 (Hsp70) was considered exclusively an intracellular chaperone contributing to protein proteostasis and in apoptotic pathway block. Lately it has been demonstrated that Hsp70 is actively released in the extracellular environment, thereby promoting the activation of the immune system by stimulating innate and adaptive responses through the activation of APCs. Its expression in the nervous system is induced in a variety of pathological conditions. Emerging evidences displayed that Hsp70 is a critical regulator in normal neural cells. Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) directed against myelin antigens. In thi…
PS5:100 Patophysiological role of type i and iii interferons in systemic lupus erythematosus (sle)
2018
Systemic Lupus erythematosus (SLE) is an autoimmune disease characterised by activated autoreactive lymphocytes and autoantibodies, resulting in tissue damage in multiple organs. An important factor for the disease´s mortality is the development of Lupus nephritis (LN). Type I and III interferons, which are both part of the antiviral defense, have both been associated with the disease´s activity. In sera and urine of SLE patients an enhanced level of IL28/29 was described, but their distinct functional role in the course of disease need to be further investigated. To determine the role of type I and III interferons during onset and progression of autoimmunity – with focus on the development…
Experimental confirmation of the 'protein traffic hypothesis' by routine diagnostic tests
2010
The 'protein traffic hypothesis' suggests that the inflammation associated with autoimmune disease, trauma and disturbances of blood circulation is the result of misguided protein trafficking. The hypothesis divides the antigen spectrum into an intracellular component and an extracellular component. While the intracellular component is recognised by MHC class-I molecules and is presented to CD8 T-lymphocytes, the extracellular component is recognised by MHC class-II molecules and is presented to CD4 T-lymphocytes. To test this hypothesis, CD4 and CD8 T-cell counts of 271 HIV-negative patients of the University Hospital, Mainz, Germany were examined retrospectively. The results corroborate t…
B7&hyphen;H1 and CD8&plus;Treg: The enigmatic role of B7&hyphen;H1 in peripheral tolerance
2009
The interaction between B7-H1 (PD-L1) expressed on APC with PD-1 expressed by T cells was shown previously to result in inhibition of T-cell activation and autoimmune diseases. A paper in this issue of the European Journal of Immunology demonstrates that DC B7-H1 expression can in fact enhance autoimmunity, rather than suppress it. Using a model of direct injection of self antigen-loaded DC into the CNS, the authors demonstrate that DC with intact B7-H1 expression exacerbate CNS autoimmune disease. Importantly, the improved disease outcome in animals treated with B7-H1(-/-) DC is a result of a population of CD8(+) Treg cells that expand at the site of autoimmune inflammation.