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RESEARCH PRODUCT
B7‐H1 and CD8+Treg: The enigmatic role of B7‐H1 in peripheral tolerance
Ari WaismanNir Yogevsubject
Autoimmune diseaseeducation.field_of_studybiologyImmunologyPopulationPeripheral tolerancemedicine.diseasemedicine.disease_causeAutoimmunityMyelin oligodendrocyte glycoproteinAntigenImmunologymedicinebiology.proteinImmunology and AllergyeducationCD8B7-H1 Antigendescription
The interaction between B7-H1 (PD-L1) expressed on APC with PD-1 expressed by T cells was shown previously to result in inhibition of T-cell activation and autoimmune diseases. A paper in this issue of the European Journal of Immunology demonstrates that DC B7-H1 expression can in fact enhance autoimmunity, rather than suppress it. Using a model of direct injection of self antigen-loaded DC into the CNS, the authors demonstrate that DC with intact B7-H1 expression exacerbate CNS autoimmune disease. Importantly, the improved disease outcome in animals treated with B7-H1(-/-) DC is a result of a population of CD8(+) Treg cells that expand at the site of autoimmune inflammation.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2009-06-01 | European Journal of Immunology |