Search results for "unusual"

Unusual roles of caspase-8 in triple-negative breast cancer cell line MDA-MB-231

2015

Triple-negative breast cancer (TNBC) is a clinically aggressive form of breast cancer that is unresponsive to endocrine agents or trastuzumab. TNBC accounts for ~10-20% of all breast cancer cases and represents the form with the poorest prognosis. Patients with TNBC are at higher risk of early recurrence, mainly in the lungs, brain and soft tissue, therefore, there is an urgent need for new therapies. The present study was carried out in MDA-MB-231 cells, where we assessed the role of caspase-8 (casp-8), a critical effector of death receptors, also involved in non‑apoptotic functions. Analysis of casp-8 mRNA and protein levels indicated that they were up-regulated with respect to the normal…

An unusual case of ureteral ectopia in the seminal vesicle: diagnosis and surgical management.

1999

We report the case of a young man who presented with numerous episodes of ipsilateral epididymitis. Selected imaging studies with consideration of urogenital embryology lead to the rare diagnosis of a dysplastic kidney with ureteral ectopia in the seminal vesicle. After nephroureterectomy and vesiculectomy, convalescence was uneventful. No specific symptoms, equivocal diagnostic findings and the small number of patients limit the surgical experience in diseases of the seminal vesicle. Suprainguinal extravesical extirpation, however, appears to be an excellent operative approach in cases of unilateral seminal vesicle cysts.

Multilayer amniotic membrane transplantation in severe ocular graft versus host disease

2001

To clarify the usefulness of multilayer amniotic membrane transplantation in an unusual case of calcareous corneal degeneration in a patient with graft-versus-host disease.A 20-year-old Caucasian woman had bilateral calcareous corneal degeneration of one year of evolution, secondary to graft-versus-host disease. Treatment for both eyes with topical steroids and antibiotic ointment was not successful. Right eye had a spontaneous corneal perforation, and a three-layer circle amniotic membrane graft was applied to the whole cornea.During a follow-up period of 20 months we observed stability of the corneal epithelium and stroma. The amniotic membrane-covered area showed rapid epithelization, re…

A rare case of congenital absence of permanent canines associated with other dental anomalies

2011

Agenesis of permanent canines is a rare condition and that of both maxillary and mandibular permanent canines is extremely rare. Reports of such cases are very scarce in the literature. It may occur either isolated or in association with other dental anomalies. This paper reports an unusual case of agenesis of both the maxillary permanent canines and mandibular right permanent canine occurring in association with congenitally missing mandibular permanent central incisors and microdontic maxillary lateral incisors in a 10 year-old Indian male.

ALIMENTAZIONE E AMBIENTI INUSUALI PER IL PIRO PIRO PICCOLO ACTITIS HYPOLEUCOS (Aves Scolopacidae)

2017

Feeding and unusual environments for Actitis hypoleucos (Aves Scolopacidae)

An unusual case of cytoplasmic CD3 expressing BPDCN supporting the T‐lineage origin of plasmacytoid dendritic cells

2021

Auditors versus third parties and others: the unusual case of the Spanish audit liability “crisis”

2000

This paper challenges the increasingly accepted position that, internationally, the audit profession is facing a major liability crisis. Its analysis of auditing developments in Spain since the late 1980s reveals an audit liability “crisis” which is more the result of the profession’s campaign to align itself with legal regimes abroad rather than a direct consequence of major legal settlements in favour of third parties. The Spanish experience is made particularly interesting by the dramatic change in the auditing profession’s stance - clearly rejecting responsibilities and legal traditions that it had willingly accepted just over a decade ago (when auditing was established in statute). A …

Anomalous and Not-So-Common Behavior in Common Ionic Liquids and Ionic Liquid-Containing Systems

2019

This work highlights unexpected, not so well known responses of ionic liquids and ionic liquid-containing systems, which are reported in a collective manner, as a short review. Examples include: (i) Minima in the temperature dependence of the isobaric thermal expansion coefficient of some ILs; (ii) Viscosity Minima in binary mixtures of IL + Molecular solvents; (iii) Anomalies in the surface tension within a family of ILs; (iv) The constancy among IL substitution of Cp/Vm at and around room temperature; (v) ILs as glass forming liquids; (vi) Alternate odd-even side alkyl chain length effects; (vii) Absolute negative pressures in ILs and IL-containing systems; (viii) Reversed-charged ionic l…

Structural basis for light control of cell development revealed by crystal structures of a myxobacterial phytochrome

2018

Phytochromes are red-light photoreceptors that were first characterized in plants, with homologs in photosynthetic and non-photosynthetic bacteria known as bacteriophytochromes (BphPs). Upon absorption of light, BphPs interconvert between two states denoted Pr and Pfr with distinct absorption spectra in the red and far-red. They have recently been engineered as enzymatic photoswitches for fluorescent-marker applications in non-invasive tissue imaging of mammals. This article presents cryo- and room-temperature crystal structures of the unusual phytochrome from the non-photosynthetic myxobacterium Stigmatella aurantiaca (SaBphP1) and reveals its role in the fruiting-body formation of this ph…

Recurrent Granular Dystrophy of the Cornea

2006

Purpose: To describe a case of severe corneal granular dystrophy with clinicopathologic and molecular genetic findings. Methods: The DNAs of a 53-year-old male patient suffering from corneal granular dystrophy and nonaffected family members was analyzed by molecular genetic methods. Clinical features, and histopathologic and immunohistochemical findings from the penetrating keratoplasty specimen, are described. Results: Histopathologic and molecular genetic findings confirmed the diagnosis. A new genetic polymorphism is described. Histopathologic evidence supports the assumption of the epithelial origin of the described dystrophy. Conclusions: A severe course of corneal granular dystrophy c…