Search results for "uva"
showing 10 items of 2916 documents
In vitrouptake of lysozyme-loaded liposomes coated with chitosan biopolymer as model immunoadjuvants
2009
Chitosan binds to negatively charged soy lecithin liposomes by an electrostatic interaction driven by its cationic amino group. This interaction allows developing stable coated vesicles suitable as a targeted carrier and controlled release system for drugs and vaccines. In this work, we studied the effect of chitosan-coated liposomes on the uptake and antigen presentation of hen egg-white lysozyme (HEL) in Peyer's patches peritoneal macrophages isolated from mice. Chitosan-coated liposomes were characterized according to size, zeta potential, and antigen-loading and release properties. Results showed an increase in the positive net charge and size of the liposomes as the concentration of ch…
Targeting cells of the immune system: mannosylated HPMA–LMA block-copolymer micelles for targeting of dendritic cells
2016
Background: Successful tumor immunotherapy depends on the induction of strong and sustained tumor antigen-specific immune responses by activated antigen-presenting cells (APCs) such as dendritic cells (DCs). Since nanoparticles have the potential to codeliver tumor-specific antigen and DC-stimulating adjuvant in a DC-targeting manner, we wanted to assess the suitability of mannosylated HPMA-LMA block polymers for immunotherapy. Materials & methods: Fluorescence-labeled block copolymer micelles derived from P(HPMA)-block-P(LMA) copolymers and according statistical copolymers were synthesized via RAFT polymerization, and loaded with the APC activator L18-MDP. Both types of copolymers wer…
Real-space imaging with pattern recognition of a ligand-protected Ag374 nanocluster at sub-molecular resolution
2018
High-resolution real-space imaging of nanoparticle surfaces is desirable for better understanding of surface composition and morphology, molecular interactions at the surface, and nanoparticle chemical functionality in its environment. However, achieving molecular or sub-molecular resolution has proven to be very challenging, due to highly curved nanoparticle surfaces and often insufficient knowledge of the monolayer composition. Here, we demonstrate sub-molecular resolution in scanning tunneling microscopy imaging of thiol monolayer of a 5 nm nanoparticle Ag374 protected by tert-butyl benzene thiol. The experimental data is confirmed by comparisons through a pattern recognition algorithm t…
A Koebe distortion theorem for quasiconformal mappings in the Heisenberg group
2017
We prove a Koebe distortion theorem for the average derivative of a quasiconformal mapping between domains in the sub-Riemannian Heisenberg group $\mathbb{H}_1$. Several auxiliary properties of quasiconformal mappings between subdomains of $\mathbb{H}_1$ are proven, including distortion of balls estimates and local BMO-estimates for the logarithm of the Jacobian of a quasiconformal mapping. Applications of the Koebe theorem include diameter bounds for images of curves, comparison of integrals of the average derivative and the operator norm of the horizontal differential, as well as the study of quasiconformal densities and metrics in domains in $\mathbb{H}_1$. The theorems are discussed for…
X-ray Tomography of One-forms with Partial Data
2021
If the integrals of a one-form over all lines meeting a small open set vanish and the form is closed in this set, then the one-form is exact in the whole Euclidean space. We obtain a unique continuation result for the normal operator of the X-ray transform of one-forms, and this leads to one of our two proofs of the partial data result. Our proofs apply to compactly supported covector-valued distributions.
Tensor tomography in periodic slabs
2017
The X-ray transform on the periodic slab $[0,1]\times\mathbb T^n$, $n\geq0$, has a non-trivial kernel due to the symmetry of the manifold and presence of trapped geodesics. For tensor fields gauge freedom increases the kernel further, and the X-ray transform is not solenoidally injective unless $n=0$. We characterize the kernel of the geodesic X-ray transform for $L^2$-regular $m$-tensors for any $m\geq0$. The characterization extends to more general manifolds, twisted slabs, including the M\"obius strip as the simplest example.
Dynamics of Quadriceps Muscles during Isometric Contractions : Velocity-Encoded Phase Contrast MRI Study
2021
Objective: To quantify the spatial heterogeneity of displacement during voluntary isometric contraction within and between the different compartments of the quadriceps. Methods: The thigh muscles of seven subjects were imaged on an MRI scanner while performing isometric knee extensions at 40% maximal voluntary contraction. A gated velocity-encoded phase contrast MRI sequence in axial orientations yielded tissue velocity-encoded dynamic images of the four different compartments of the thigh muscles (vastus lateralis (VL), vastus medialis (VM), vastus intermedius (VI), and rectus femoris (RF)) at three longitudinal locations of the proximal–distal length: 17.5% (proximal), 50% (middle), and 7…
Transversus abdominis and multifidus asymmetry in runners measured by MRI: a cross-sectional study
2019
ObjectiveThe transversus abdominis muscle (TrA) is active during running as a secondary respiratory muscle and acts, together with the multifidus, as trunk stabiliser. The purpose of this study was to determine size and symmetry of TrA and multifidus muscles at rest and with contraction in endurance runners without low back pain.DesignCross-sectional study.SettingA medical imaging centre in Melbourne, Australia.ParticipantsThirty middle-aged (43years±7) endurance-trained male (n=18) and female (n=12) runners without current or history of low back pain.Outcome measuresMRI at rest and with the core engaged. The TrA and multifidus muscles were measured for thickness and length (TrA) and antero…
Processo di melanogenesi nel trattamento delle iperpigmentazioni: fisiologia e trattamento
2012
Processo di melanogenesi nel trattamento delle iperpigmentazioni: fisiologia e trattamento Matteo Tutino, Giuseppe Morici, L. Cavarra, Francesco Nanfitò, D. Camacaro, Vittorio Calabrese. Università di Palermo, Dipartimento di Biomedicina sperimentale e neuroscienze cliniche - Università di Catania, Dipartimento Biochimica Clinica La melanogenesi è il processo mediante il quale è prodotta la melanina, conferendo pigmento alla pelle. Responsabile della produzione della melanina è il melanocita. Tuttavia è possibile parlare di una vera e propria unità cheratinocita- melanocita. Infatti entrambe queste cellule si attivano a seguito di aggressioni di qualunque tipo a cui la pelle viene sottopost…
Comparative effects of carrier proteins on vaccine-induced immune response
2011
The efficacy of vaccines against major encapsulated bacterial pathogens -Neisseria meningitidis, Streptococcus pneumoniae, and Haemophilus influenzae type b (Hib) - has been significantly enhanced by conjugating the respective polysaccharides with different carrier proteins: diphtheria toxoid; non-toxic cross-reactive material of diphtheria toxin(197), tetanus toxoid, N. meningitidis outer membrane protein, and non-typeable H. influenzae-derived protein D. Hib, meningococcal, and pneumococcal conjugate vaccines have shown good safety and immunogenicity profiles regardless of the carrier protein used, although data are conflicting as to which carrier protein is the most immunogenic. Coadmini…