Search results for "valve disease"

showing 10 items of 54 documents

Simulation study of transcatheter heart valve implantation in patients with stenotic bicuspid aortic valve

2019

Bicuspid aortic valve (BAV) anatomy has routinely been considered an exclusion in the setting of transcatheter aortic valve implantation (TAVI) because of the large dimension of the aortic annulus having a more calcified, bulky, and irregular shape. The study aims to develop a patient-specific computational framework to virtually simulate TAVI in stenotic BAV patients using the Edwards SAPIEN 3 valve (S3) and its improved version SAPIEN 3 Ultra and quantify stent frame deformity as well as the severity of paravalvular leakage (PVL). Specifically, the aortic root anatomy of n.9 BAV patients who underwent TAVI was reconstructed from pre-operative CT imaging. Crimping and deployment of S3 fram…

MaleModels Anatomicmedicine.medical_treatment02 engineering and technology030218 nuclear medicine & medical imaging0302 clinical medicineBicuspid aortic valveBicuspid Aortic Valve DiseaseImage Processing Computer-AssistedCardiac skeletonPrecision MedicineAged 80 and overCardiac cycleSettore ING-IND/34 - Bioingegneria IndustrialeComputer Science Applicationsmedicine.anatomical_structureSurgery Computer-Assistedcardiovascular systemCardiologyFemalemedicine.symptommedicine.medical_specialtyBicuspid aortic valve0206 medical engineeringFinite Element AnalysisBiomedical EngineeringDiastoleTranscatheter Aortic Valve Replacement03 medical and health sciencesFluid-solid interactionInternal medicinePreoperative CaremedicineDeformityHumansIn patientHeart valveAgedRetrospective StudiesTranscatheter aortic valve implantationbusiness.industryStentComputational BiologyFinite-element analysiAortic Valve Stenosismedicine.disease020601 biomedical engineeringbusinessTomography X-Ray ComputedEchocardiography Transesophageal
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Associations of rs3918242 and rs2285053 MMP-9 and MMP-2 polymorphisms with the risk, severity, and short- and long-term complications of degenerative…

2016

Abstract Background Degenerative forms of mitral valve diseases (MVDs) are very complex pathologies. Thus, it is difficult to make generalizations about the disease pathways or genetic risk factors contributing to these diseases. However, a key role of metalloproteinases (MMPs) in their pathophysiology is emerging. Thus, we performed for the first time a perspective study to assess eventual associations of some functional single nucleotide polymorphisms (SNPs) in MMP-2 and MMP-9 genes with the MVD risk, symptom severity, and short- and long-term (4.8 years) complications. Materials and methods For this purpose, 90 patients and two control groups were genotyped for rs3918242, rs243865, and r…

MalePathologyHeart Valve DiseasesDisease030204 cardiovascular system & hematologyMatrix metalloproteinasers3918242 rs243865 rs2285053 MMP-2 and MMP-9 gene SNPDegenerative forms of mitral valve diseases; Management and outcome; Metalloproteinases; rs3918242 rs243865 rs2285053 MMP-2 and MMP-9 gene SNPs; Aged; Cohort Studies; Female; Genetic Predisposition to Disease; Genotype; Heart Valve Diseases; Humans; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Middle Aged; Mitral Valve; Prospective Studies; Risk Factors; Polymorphism Single Nucleotide0403 veterinary scienceCohort Studies0302 clinical mediciners2285053 MMP-2 and MMP-9 gene SNPsRisk FactorsGenotypeManagement and outcomeNatriuretic peptideProspective StudiesProspective cohort studyMVDSMetalloproteinaseDegenerative forms of mitral valve diseases04 agricultural and veterinary sciencesGeneral MedicineSingle NucleotideMiddle AgedMetalloproteinasesPathophysiologyMatrix Metalloproteinase 9Matrix Metalloproteinase 2Mitral ValveFemalers3918242Cardiology and Cardiovascular MedicineDegenerative forms of mitral valve diseasemedicine.medical_specialtyGenotype040301 veterinary sciencesmedicine.drug_class2734Single-nucleotide polymorphismDegenerative forms of mitral valve diseases; Management and outcome; Metalloproteinases; rs3918242 rs243865 rs2285053 MMP-2 and MMP-9 gene SNPs; Cardiology and Cardiovascular Medicine; 2734Polymorphism Single NucleotidePathology and Forensic Medicine03 medical and health sciencesInternal medicinemedicineHumansGenetic Predisposition to Diseasers243865PolymorphismAgedbusiness.industrySettore MED/23 - Chirurgia Cardiacabusiness
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Three-dimensional parametric modeling of bicuspid aortopathy and comparison with computational flow predictions

2016

Bicuspid aortic valve (BAV)-associated ascending aneurysmal aortopathy (namely “bicuspid aortopathy”) is a heterogeneous disease making surgeon predictions particularly challenging. Computational flow analysis can be used to evaluate the BAV-related hemodynamic disturbances, which likely lead to aneurysm enlargement and progression. However, the anatomic reconstruction process is time consuming so that predicting hemodynamic and structural evolution by computational modeling is unfeasible in routine clinical practice. The aim of the study was to design and develop a parametric program for three-dimensional (3D) representations of aneurysmal aorta and different BAV phenotypes starting fr…

MalePatient-Specific ModelingBicuspid aortic valveComputed Tomography AngiographyHeart Valve DiseasesBiomedical EngineeringMedicine (miscellaneous)Bioengineering—Three-dimensional anatomic reconstructionElectrocardiographyImaging Three-DimensionalBicuspid Aortic Valve DiseaseSettore ING-IND/12 - Misure Meccaniche E TermicheHumans—Finite-element analysiProspective StudiesAortaAgedRetrospective Studies—Aortic failureHemodynamicsModels CardiovascularComputational BiologySettore ING-IND/34 - Bioingegneria IndustrialeMiddle AgedBiomaterialAortic Aneurysm—Ascending thoracic aortic aneurysmAortic ValveFemaleStress MechanicalSoftware
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Non-sutureless minimally invasive aortic valve replacement: mini-sternotomy versus mini-thoracotomy: a series of 1130 patients

2016

Objectives Aortic valve replacement through conventional sternotomy still represents the gold-standard surgical approach for aortic valve disease. However, given the increasing number of patients with comorbidities, strategies that can improve operative results are always sought. Minimally invasive aortic valve surgery, although related to a steep learning curve, might be associated with improved postoperative outcomes. The main aim of this study was to assess whether significant differences exist in terms of operative and early results between a mini-sternotomy and a right mini-thoracotomy approach for isolated aortic valve replacement without sutureless technologies. Methods This is an ob…

MalePulmonary and Respiratory MedicineAortic valveAortic valve replacement • Exposure • Incision • Minimally invasive surgery • Surgery • Techniquemedicine.medical_specialtymedicine.medical_treatmentHeart Valve Diseases030204 cardiovascular system & hematologylaw.invention03 medical and health sciences0302 clinical medicineAortic valve replacementlawmedicineCardiopulmonary bypassHumansMinimally Invasive Surgical ProceduresThoracotomyAgedRetrospective StudiesHeart Valve Prosthesis Implantationbusiness.industrySuture TechniquesAortic valve disorderRetrospective cohort studymedicine.diseaseSternotomySurgerymedicine.anatomical_structureThoracotomy030228 respiratory systemAortic ValveHeart Valve ProsthesisAortic valve surgeryFemaleSurgeryObservational studyCardiology and Cardiovascular Medicinebusiness
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Histological and genetic studies in patients with bicuspid aortic valve and ascending aorta complications.

2011

OBJECTIVES: Aneurysm diameter and growing rate does not represent a definite parameter for operation in bicuspid aortic valve (BAV), ascending aortic aneurysm and normal root patients. Thus, we investigated histological and immunohistochemical aspects of different segments of ascending aorta (precisely, aortic root without dilatation, aneurysmatic tubular portion, dissected ascending aorta) and genetic features of patients with BAV and ascending aorta complication (aneurysm or dissection). METHODS: Aorta tissue samples of 24 BAV patients were examined. The patients comprised of 18 men and 6 women; the mean age was 54.2 ± 14.3 years. All patients underwent composite aortic root replacement (…

MalePulmonary and Respiratory MedicineAortic valveGenotypeBicuspid aortic valveHeart Valve DiseasesAorta ThoracicApoptosisPolymerase Chain ReactionPolymorphism Single NucleotideAortic aneurysmAneurysmBicuspid aortic valveRisk Factorsmedicine.arteryAscending aortaIn Situ Nick-End LabelingmedicineHumansThoracic aortaSettore MED/05 - Patologia ClinicaGenetic Predisposition to DiseaseCystRetrospective StudiesAortaAortic Aneurysm Thoracicbusiness.industryDissectionSettore MED/23 - Chirurgia CardiacaFollow-up PapersDNAAnatomyMiddle Agedmedicine.diseaseImmunohistochemistryAneurysmEchocardiography Doppler ColorAortic Dissectionmedicine.anatomical_structureAortic Valvecardiovascular systemFemaleSurgeryCardiology and Cardiovascular MedicinebusinessBiomarkersEchocardiography TransesophagealFollow-Up Studies
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Bicuspid aortic valve and unruptured sinus of Valsalva aneurysm, a rare association

2016

Bicuspid aortic valve (BAV) is one of the most common forms of congenital heart defect and is associated with other congenital vascular and cardiac defects. The most common comorbidity is dilation of thoracic aorta and clinical manifestations are usually related to function of the aortic valve and to other cardiovascular acquired complications. Sinus of Valsalva aneurysm (SVA) is an uncommon congenital cardiovascular anomaly and the combination of these two anomalies is very rare. Common complications are rupture and obstruction of the termination chamber due to space-occupying effect of large unruptured aneurysms. Early cardiac imaging can help limiting morbidity and mortality in these pat…

Malemedicine.medical_specialtyBicuspid aortic valve030204 cardiovascular system & hematology03 medical and health sciences0302 clinical medicineAneurysmBicuspid aortic valveInternal medicineIncidental Findingmedicine030212 general & internal medicineSinus (anatomy)business.industryMedicine (all)Middle AgedSinus of Valsalvamedicine.diseaseAneurysmSettore MED/11 - Malattie Dell'Apparato CardiovascolareSurgeryAortic AneurysmHeart Valve Diseasemedicine.anatomical_structureAortic ValveCardiologyValsalva SinusValsalva sinubusinessCardiology and Cardiovascular MedicineSettore MED/36 - Diagnostica Per Immagini E RadioterapiaHuman
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Patients with bicuspid aortic valve are likely to receive an aortic valve prosthesis during prophylactic resection of their ascending aortic aneurysm.

2015

This study aims to evaluate whether thepresence or discovery of a BAV under ATAA repair would impactthe decision-making of the surgical procedure choice.

Malemedicine.medical_specialtyBicuspid aortic valveAortic valve prosthesisHeart Valve Diseases030204 cardiovascular system & hematologyResectionProphylactic Surgical Procedure03 medical and health sciencesAortic aneurysm0302 clinical medicineBicuspid aortic valveBicuspid Aortic Valve DiseaseRetrospective StudieInternal medicineMedicineHumans030212 general & internal medicineAgedRetrospective Studiesbusiness.industrySettore ING-IND/34 - Bioingegneria IndustrialeProphylactic Surgical ProceduresMiddle Agedmedicine.diseaseAortic surgeryAortic AneurysmHeart Valve DiseaseAortic ValveHeart Valve ProsthesisCardiologyFemaleCardiology and Cardiovascular MedicinebusinessAortic surgeryHumanInternational journal of cardiology
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The influence of Albunex on the pulmonary circulation in patients with pulmonary hypertension or left heart failure.

1996

To determine the safety of the ultrasound contrast agent Albunex, its influence on right and left heart haemodynamics in patients with pulmonary artery hypertension or left heart failure was assessed after intravenous injection. Patients with a left ventricular ejection fraction smaller than 40% or a systolic pulmonary artery pressure greater than 40 mmHg received 0.08 and 0.22 ml.kg -1 Albunex and 10 ml albumin in random order during right heart catheterization and transthoracic echocardiography. Right atrial, systolic and diastolic pulmonary artery and capillary wedge pressures were measured at 3 min and 5 min and cardiac output at 5 min after the intravenous injection of Albunex and cont…

Malemedicine.medical_specialtyCardiac outputPulmonary CirculationHypertension PulmonaryHeart Valve DiseasesContrast MediaBlood PressureCoronary DiseasePulmonary ArteryElectrocardiographyInternal medicinemedicine.arteryAlbuminsmedicineHumansSystoleAtrium (heart)Ejection fractionbusiness.industryCentral venous pressureHemodynamicsMiddle Agedmedicine.diseasePulmonary hypertensionmedicine.anatomical_structureEchocardiographyHeart failurePulmonary arteryInjections IntravenousCardiologyFemaleCardiology and Cardiovascular MedicinebusinessEuropean heart journal
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Matrix Metalloproteinases (MMPs), Their Genetic Variants and miRNA in Mitral Valve Diseases: Potential Biomarker Tools and Targets for Personalized T…

2016

Mitral valve diseases (MVD)s, comprising congenital and acquired forms, are characterized by a diverse etiology, pathophysiology, prevalence, and incidence. In industrialized countries, the acquired forms represent 2.5% of all cardiovascular diseases, with a marked augmentation after the age of 65 years. In addition, all forms of MVDs (i.e., degenerative forms) have a difficult clinical management. The major challenge is 'the early diagnosis', and echocardiographic analysis has been shown inappropriate for diagnosing MVD in moderate forms. Thus, there is a strong need to identify more appropriate biomarker tools to diagnose MVDs at early clinical stage before complications occur and worsen …

MicroRNAsMitral valve diseaseHeart Valve DiseasesHumansMitral ValveSettore MED/05 - Patologia ClinicaSettore MED/23 - Chirurgia CardiacaPrognosisPolymorphism Single NucleotideBiomarkersMatrix Metalloproteinasesmatrix metalloproteinase (MMP) pathwaysSignal Transduction
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The Endothelial Transcription Factor ERG Mediates a Differential Role in the Aneurysmatic Ascending Aorta with Bicuspid or Tricuspid Aorta Valve: A P…

2022

The pathobiology of ascending aorta aneurysms (AAA) onset and progression is not well understood and only partially characterized. AAA are also complicated in case of bicuspid aorta valve (BAV) anatomy. There is emerging evidence about the crucial role of endothelium-related pathways, which show in AAA an altered expression and function. Here, we examined the involvement of ERG-related pathways in the differential progression of disease in aortic tissues from patients having a BAV or tricuspid aorta valve (TAV) with or without AAA. Our findings identified ERG as a novel endothelial-specific regulator of TGF-β-SMAD, Notch, and NO pathways, by modulating a differential fibrotic or calcified A…

NotchHeart Valve DiseasesCatalysisInorganic ChemistryBicuspid Aortic Valve DiseaseTranscriptional Regulator ERGascending aorta aneurysm; bicuspid aorta valve; tricuspid aorta valve; ERG transcriptional factor pathway; TGF-β-SMAD; Notch; NO pathways modulationTransforming Growth Factor betaSettore MED/05 - Patologia ClinicaHumansTGF-β-SMADEndotheliumPhysical and Theoretical ChemistryMolecular BiologySpectroscopyAortabicuspid aorta valveOrganic ChemistryERG transcriptional factor pathwayGeneral Medicineascending aorta aneurysmComputer Science ApplicationsSettore MED/23Aortic Valvetricuspid aorta valveNO pathways modulationBiomarkersTranscription FactorsInternational Journal of Molecular Sciences; Volume 23; Issue 18; Pages: 10848
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