Search results for "variant"

Identificación de variantes genéticas poco frecuentes y raras en Diabetes mellitus tipo 2 mediante secuenciación de exoma

2015

Identificación de variantes genéticas poco frecuentes y raras en diabetes mellitus tipo 2 mediante secuenciación de exoma. La diabetes mellitus tipo 2 (DM2) se ha convertido en una epidemia global que contribuye significativamente a la morbi-mortalidad prematura. La DM2 es resultado de múltiples factores, incluyendo ambientales, genéticos y adquiridos. Se ha demostrado que la heredabilidad de la DM2 se encuentra alrededor del 70%. No obstante, los estudios realizados sólo han podido identificar una pequeña proporción del componente genético de la enfermedad. El resto del componente podría residir, en parte, en variantes genéticas poco frecuentes (MAF 20 y con valores predictivos de alteraci…

Enantioseparations with polysaccharide-based chiral stationary phases in HPLC. Application to the enantioselective evaluation of the biodegradability…

2023

The chiral nature of living systems has obvious implications for the biologically active compounds that interact with them. At the molecular level, chirality represents an intrinsic property of the essential building blocks of life, such as amino acids and sugars, and therefore, of peptides, proteins, enzymes, carbohydrates, nucleosides and a number of alkaloids and hormones. As a consequence, processes mediated by biological systems are stereochemistry-sensitive, and a pair of enantiomers can have different effects on living organisms. The scientific community has been studying the implications of chirality for life for more than a century. Today, it is still a topic of active research and…

A model for the γN → ππN reaction

1996

We have studied the γN → ππN reaction using a model wich includes N, Δ(1232), N*(1440) and N*(1520) intermediate baryonic states and the ρ-meson as a intermediate ππ resonance. The model reproduces fairly well experimental cross sections below Eγ=800 MeV and invariant-mass distributions even at higher energies. One of the interesting findings of study is what the γN → N*(1520) → Δπ process is very important and interferes strongly with the dominant Δ-Kroll-Ruderman term to produce the experimental peak of the kross section. Oset Baguena, Eulogio, Eulogio.Oset@ific.uv.es

Identifying gene-environment interactions in schizophrenia: contemporary challenges for integrated, large-scale investigations

2014

European Community Recent years have seen considerable progress in epidemiological and molecular genetic research into environmental and genetic factors in schizophrenia, but methodological uncertainties remain with regard to validating environmental exposures, and the population risk conferred by individual molecular genetic variants is small. There are now also a limited number of studies that have investigated molecular genetic candidate gene-environment interactions (G x E), however, so far, thorough replication of findings is rare and G x E research still faces several conceptual and methodological challenges. in this article, we aim to review these recent developments and illustrate h…

Lingue, invarianti e altri strani oggetti

2011

The paper aims to analyze the concept of linguistic invariant introduced by several research programs in linguistics: from the typological linguistics to the theory of enunciative and predicative operations until some branches of the so-called Minimalist program. As we will shows, it is necessary to distinguish between «universals of language» and «linguistic invariant».

Sempre uguale sempre diverso. Riflessioni sulla nozione di invariante linguistico

2008

The paper aims to analyze the concept of linguistic invariant. It is a theoretical tool that plays a pivotal role in several research programs: from the typological linguistics to the theory of enunciative and predicative operations, until some branches of the so-called Minimalist program. As we will show, it is necessary to distinguish between «universal of language» and «linguistic invariant».

Automatic Relative Radiometric Normalization of Bi-Temporal Satellite Images Using a Coarse-to-Fine Pseudo-Invariant Features Selection and Fuzzy Int…

2022

Relative radiometric normalization (RRN) is important for pre-processing and analyzing multitemporal remote sensing (RS) images. Multitemporal RS images usually include different land use/land cover (LULC) types; therefore, considering an identical linear relationship during RRN modeling may result in potential errors in the RRN results. To resolve this issue, we proposed a new automatic RRN technique that efficiently selects the clustered pseudo-invariant features (PIFs) through a coarse-to-fine strategy and uses them in a fusion-based RRN modeling approach. In the coarse stage, an efficient difference index was first generated from the down-sampled reference and target images by combining…

Estudio contrastivo lingüístico y semántico de las construcciones verbales fijas diatópicas mexicanas/españolas

2010

En este artículo analizamos las construcciones verbales fijas de origen mexicano, y las compararemos con construcciones homólogas del español peninsular desde el punto de vista lingüístico y semántico con el fin de poner de relieve las peculiaridades de estas variantes diatópicas. In the present paper, we analyse set verbal constructions of Mexican origin and compare them with homologous verbal constructions of European Spanish origin from a morphological and semantic point of view in order to underline the peculiarities of the Mexican, diatopic varieties.

VARIAZIONI anatomiche del seno sfenoidale VALUTATI IN MDTC

2009

Spatial and temporal distribution of SARS-CoV-2 diversity circulating in wastewater

2022

Wastewater-based epidemiology (WBE) has proven to be an effective tool for epidemiological surveillance of SARS-CoV-2 during the current COVID-19 pandemic. Furthermore, combining WBE together with high-throughput sequencing techniques can be useful for the analysis of SARS-CoV-2 viral diversity present in a given sample. The present study focuses on the genomic analysis of SARS-CoV-2 in 76 sewage samples collected during the three epidemiological waves that occurred in Spain from 14 wastewater treatment plants distributed throughout the country. The results obtained demonstrate that the metagenomic analysis of SARS-CoV-2 in wastewater allows the detection of mutations that define the B.1.1.…