6533b870fe1ef96bd12d081f

RESEARCH PRODUCT

Identifying gene-environment interactions in schizophrenia: contemporary challenges for integrated, large-scale investigations

Rosana ShuhamaGonzalo LópezViviana StorbiniTolga BinbayMa Soledad OlmedaMaria CalemMarina MihaljevicChristos PantelisHalis UlaşEva VelthorstJeroen DecosterJ. Malte BumbRuud Van WinkelE. Cem AtbasogluWolfgang ViechtbauerMirella RuggeriErich StuderusDaniele La BarberaDomenico BerardiAnita Riecher-rösslerStefan BorgwardtElsje Van Der VenCharlotte RappDesiree HilbollMark Van Der GaagChiara BonettoMarie-odile KrebsSilvia TenanMonika SchlögelhoferRobin M. Murray La Cascia CaterinaPhilip McguireSimona A. StiloDesmond CampbellFabienne HarrisbergerTeresa SánchezCatherine DeromFranck SchürhoffPhilippe DelespaulJose Luis SantosEmilio SánchezStephan RuhrmannLuigi Rocco ChiriSabrina CruzHandan NoyanDominika JulkowskiCelso ArangoMerete NordentoftStacey S. ChernyAnne-marie GalliotDaniella Van DamMaría PousoAsier Urruela MoraG. Paul AmmingerEnrique García BernardoAhmet AyerTijana MirjanicAndrei SzökeAnna WalterAntonio LasalviaIsla HumphreysFlora FrijdaLieuwe De HaanNeus Barrantes-vidalNigel WilliamsBurçin CihanMatthew J. KemptonCeren AkdenizTamar KraanAndrea TortelliBarnaby NelsonMarta Di FortiAngelo FiorittiPedro CuadradoEylem Sahin CankurtaranEmanuel SchwarzAndreas Meyer-lindenbergIlaria TarriconeLaura FerraroDan RujescuAnne-marie TroncheAnne-marie TroncheLaura RoldanBibiana CabreraAlp ÜçOkCraig MorganJulio SanjuánMauro BracaJulio BobesEric Y.h. ChenMichael Conlon O'donovanPeter HolmansHarald N. AschauerSarah IttigCovadonga MartínezIris LasserEmiliano GonzálezAitziber Emaldi CiriónRachele SartorioF. SeminerioRodrigo A. BressanUlrich ReininghausUlrich ReininghausElisa BrietzkeFrançois BourqueG TripoliInez Myin-germeysAziz FerchiouGemma ModinosGrégoire BaudinFabienne Soguel-dit-piquardCristina Marta Del-benGabriele SachsElçin AkturanManuel ArrojoThomas R. KwapilAlice MulèEva Mª Díaz MesaFederico ChierziKöksal AlptekinFloor J. Van Der MeerPak C. ShamJim Van OsJim Van OsAdanna OnyejiakaMara ParelladaBart P. F. RuttenJeanne VilainMichael John OwenSarah TosatoHaldan SoygürA.m. MarinaroStefania TogninEvert ThieryCathrin RohlederMary CannonMiaoxin LiF. Markus LewekeMarc De HertMarta RapadoMaria Gabriella MinennaPierre-michel LlorcaPierre-michel LlorcaAlexander RichardsStéphane JamainStéphane JamainElles MesschaertNadja P. MaricSemra UlusoyElisa IraPeter G. JonesPaulo Rossi MenezesPatrick McgorryBernadette WinklbaurStephanie BeardsNadine BurgerGüvem Gümüş-akayMarion LeboyerJames B. KirkbrideJames B. KirkbrideSinan GuloksuzSinan GuloksuzAry GadelhaE. BulzackaCarlos M. Romeo-casabonaGülşah KaradayıJean-paul SeltenJosé Juan Rodríguez SolanoKathryn HubbardEstela JiménezThomas CharpeaudThomas CharpeaudNikos C. StefanisLucia SideliMiguel BernardoJean-romain RichardJean-romain RichardIvonne DoneganiMarco SeriLucia ValmaggiaJulia ParuchCatherine Van ZelstMeram Can SakaHeike TostRenata SmieskovaThomas MarcacciNicholas John CraddockBerna Binnur AkdedeJoachim KlosterkötterRichard BruggemanCharlotte Gayer-andersonSanja AndricElena BonoraAngel CarracedoHasan KaradağPaula Cristobal

subject

URBANICITYSchizophrenia (object-oriented programming)CHILDHOODGenome-wide association studyVARIANTSSocial Environmentpsychosi03 medical and health sciences0302 clinical medicinePSYCHOSISepidemiology; gene-environment interaction; genetics; psychosis; schizophreniaSDG 3 - Good Health and Well-beingRISK-FACTORSettore M-PSI/08 - Psicologia ClinicaGenetic variationHumansGenetic Predisposition to DiseasegeneticspsychosisGENOME-WIDE ASSOCIATIONGeneSettore MED/25 - PsichiatriaMETAANALYSISScale (chemistry)schizophrenia; gene-environment interaction; Psychosis; epidemiology; geneticsGenetic variantsEnvironment and Schizophrenia InvitedCANNABIS USE3. Good health030227 psychiatrygene-environment interactionschizophreniaPsychiatry and Mental healthEvolutionary biology/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_beingIdentification (biology)Schizophrenic PsychologyepidemiologyPopulation RiskgeneticPsychologyFOLLOW-UP030217 neurology & neurosurgeryFUTURE-DIRECTIONSClinical psychology

description

European Community Recent years have seen considerable progress in epidemiological and molecular genetic research into environmental and genetic factors in schizophrenia, but methodological uncertainties remain with regard to validating environmental exposures, and the population risk conferred by individual molecular genetic variants is small. There are now also a limited number of studies that have investigated molecular genetic candidate gene-environment interactions (G x E), however, so far, thorough replication of findings is rare and G x E research still faces several conceptual and methodological challenges. in this article, we aim to review these recent developments and illustrate how integrated, large-scale investigations may overcome contemporary challenges in G x E research, drawing on the example of a large, international, multi-center study into the identification and translational application of G x E in schizophrenia. While such investigations are now well underway, new challenges emerge for G x E research from late-breaking evidence that genetic variation and environmental exposures are, to a significant degree, shared across a range of psychiatric disorders, with potential overlap in phenotype. 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yearjournalcountryeditionlanguage
2014-07-01
10.1093/schbul/sbu069https://pure.amc.nl/en/publications/identifying-geneenvironment-interactions-in-schizophrenia-contemporary-challenges-for-integrated-largescale-investigations(d523f452-0878-44c6-9897-1b6eef9b068f).html