Search results for "genetic"

E163L HOMOZYGOUS DJ-1 MUTATION IN A FAMILY FROM SOUTHERN ITALY WITH AMIOTROPHIC LATERAL SCLEROSIS-PARKINSONISM-DEMENTIA COMPLEX.

2004

Caracterización molecular y análisis poblacional de la variabilidad del DNA mitocondrial del áfido Rhopalosiphum padi (Homoptera: Aphidiade)

1994

Comparative Cytogenetic Analysis of Three Stylommatophoran Slugs (Mollusca, Pulmonata)

2009

system is still controversial because phylogeny and systematic relationships at the family level are poorly understood. Besides morphological studies, ribosomal RNA genes and the H3/H4 histone gene cluster (Ambruster et al., 2005; Wade et al., 2006) have also been used to resolve the relationships within this order. Recently, by comparison of primary sequence of mitochondrial and nuclear genes, Grande et al. (2004) resolved the Stylommatophora as the early split monophyletic sister group of all the other gastropod taxa. Available data on the cytogenetics of Stylommatophora are extremely poor (reviewed by Patterson, 1969, and Thiriot-Quievreux, 2003) and mostly concern the haploid (n) and/ o…

P3‐039: Axonal neuritic pathology induces early presynaptic alterations in ps1/APP Alzheimer's mice hippocampus

2011

Loss of neurons in the hippocampus correlates with memory impairment in AD. Significant early reduction in the numerical density of hippocampal SOM interneurons was found in single (APPswe) and double (APPswe/ PS1dE9 and APPswe/TauP301S-G272V) transgenic models based on APP over expression and amyloid production. However, this inhibitory population was unaffected in age-matched single PS1 and tau transgenic mice as well as nontransgenic controls. Whereas SOM neuron loss in APPswe/PS1dE9 was associated to the onset of extracellular amyloid pathology in double APP/ tau mice this loss preceded plaque formation. Conclusions: As in human AD, somatostatin cell loss is a common early pathological …

2015

Songs in passerine birds are important for territory defense and mating. Speciation rates in oscine passerines are so high, due to cultural evolution, that this bird lineage makes up half of the extant bird species. Leaf warblers are a speciose Old-World passerine family of limited morphological differentiation, so that songs are even more important for species delimitation. We took 16 sonographic traits from song recordings of 80 leaf warbler taxa and correlated them with 15 potentially explanatory variables, pairwise, and in linear models. Based on a well-resolved molecular phylogeny of the same taxa, all pairwise correlations were corrected for relatedness with phylogenetically independe…

Mutagenit�tspr�fung bestrahlter Lebensmittel mit dem ?dominant lethal test?

1973

An insgesamt 716 Ratten und 750 Mausen wurde eine mogliche mutagene Wirkung einer bestrahlten Nahrung gepruft. Fertilitat, Tragezeitdauer, Wurfgrose, Aufzuchtleistung und Geschlechtsverhaltnis zeigten in 5 aufeinanderfolgenden Rattengenerationen keine Storungen in der Reproduktionsfahigkeit an. Es konnte kein Anstieg der Misbildungsrate bei den Rattenfeten beobachtet werden. Auch die Fruchtbarkeit der mannlichen und der weiblichen Tiere der Mausegeneration war ungestort. Durch den “dominant lethal test” an Ratten und Mausen konnte keine embryotoxische oder mutagene Wirkung der bestrahlten Nahrung festgestellt werden, die sich in mit den verwendeten statistischen Methoden erfasbaren Untersch…

Elektrophysiologische Untersuchung zum Einsatz von Streptolysin O und Natrium-Hyaluronat zur Permeabilitätsmodulation der Membran des runden Fensters…

2003

Background: The round window membrane (RWM) acts like a barrier for topically applied substances into the middle ear preventing diffusion into the perilymphatic fluid compartment. Material and Method: In an animal model, modulation of the permeability of the RWM was attempted using Streptolysin-O (SLO) in various concentrations and sodium hyaluronate. Thereafter, the effect of intratympanically applied Lidocain 2% on hearing threshold measured by auditory brainstem response was tested for Lidocain 2 % and Lidocain 2 % in combination with SLO or sodium hyaluronate. Results: The results show that both, SLO and sodium hyaluronate, influence the effect of Lidocain 2 % on hearing thresholds as a…

Bioactivation of the Fungal Phytotoxin 2,5-Anhydro-D-glucitol by Glycolytic Enzymesisan Essential Component of itsMechanism of Action

2002

An isolate of Fusarium solani, NRRL 18883, produces the natural phytotoxin 2,5-anhydro-ᴅ-glucitol (AhG). This fungal metabolite inhibited the growth of roots (I50 of 1.6 mᴍ), butit did nothave any in vitro inhibitory activity. The mechanism of action of AhG requires enzymatic phosphorylation by plant glycolytic kinases to yield AhG-1,6-bisphosphate (AhG-1,6- bisP), an inhibitor of Fru-1,6-bisP aldolase. AhG-1,6-bisP had an I50 value of 570 μᴍ on aldolase activity, and it competed with Fru-1,6-bisP for the catalytic site on the enzyme, with a Ki value of 103 μᴍ. The hydroxyl group on the anomeric carbon of Fru-1,6-bisP is required for the formation of an essential covalent bond to ζ amino fu…

Association between polymorphisms in the leptin promoter and leptin receptor genes and cancer in a mediterranean population of the PREDIMED study

2016

WWOX, a Chromosomal Fragile Site Gene and its Role in Cancer

2006

Allelic imbalances affecting the long arm of chromosome 16 have been extensively reported in the literature as common abnormalities observed in various carcinoma types, As a result of loss of heterozygosity (LOH) studies in breast cancer, we delimited a genomic area within chromosome 16 that demonstrated the highest frequency of abnormalities. This led us to the identification and cloning of WWOX, a candidate tumor suppressor gene (TSG) that spans a fragile region of DNA located at 16q23.3-24.1 (FRA16D: the second most active common chromosomal fragile site in the human genome). This gene encodes a protein that contains two WW domains responsible of protein-protein interactions and a short-…