Search results for "very"

Intrusion detection applications using knowledge discovery and data mining

2014

Causality-Aware Convolutional Neural Networks for Advanced Image Classification and Generation

2023

Smart manufacturing uses emerging deep learning models, and particularly Convolutional Neural Networks (CNNs) and Generative Adversarial Networks (GANs), for different industrial diagnostics tasks, e.g., classification, detection, recognition, prediction, synthetic data generation, security, etc., on the basis of image data. In spite of being efficient for these objectives, the majority of current deep learning models lack interpretability and explainability. They can discover features hidden within input data together with their mutual co-occurrence. However, they are weak at discovering and making explicit hidden causalities between the features, which could be the reason behind the parti…

Towards a New System for the Assessment of the Quality in Care Pathways: An Overview of Systematic Reviews.

2020

Clinical or care pathways are developed by a multidisciplinary team of healthcare practitioners, based on clinical evidence, and standardized processes. The evaluation of their framework/content quality is unclear. The aim of this study was to describe which tools and domains are able to critically evaluate the quality of clinical/care pathways. An overview of systematic reviews was conducted, according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses, using Medline, Embase, Science Citation Index, PsychInfo, CINAHL, and Cochrane Library, from 2015 to 2020, and with snowballing methods. The quality of the reviews was assessed with Assessment the Methodology of Systemati…

Molecular Mechanisms of the Blockage of Glioblastoma Motility

2021

Glioblastoma (GBM) is the most common and lethal brain tumor. GBM has a remarkable degree of motility and is able to infiltrate the healthy brain. In order to perform a rationale-based drug-repositioning study, we have used known inhibitors of two small Rho GTPases, Rac1 and Cdc42, which are upregulated in GBM and are involved in the signaling processes underlying the orchestration of the cytoskeleton and cellular motility. The selected inhibitors (R-ketorolac and ML141 for Cdc42 and R-ketorolac and EHT 1864 for Rac1) have been successfully employed to reduce the infiltration propensity of GBM in live cell imaging studies. Complementarily, all-atom simulations have elucidated the molecular …

Phenolic Profiles, Antioxidant and Anti-Inflammatory Activities of Hydrodistillation Wastewaters from Five Lamiaceae Species

2022

Distillation is the most widely used method to obtain an essential oil from plant material. The biomass used in the process is returned as a solid residue together with variable amounts of water rich in water-soluble compounds, which currently are not addressed to any further application. The scope of this work was to evaluate the phytochemical composition of wastewaters coming from hydrodistillation (DWWs) of five aromatic plants belonging to the Lamiaceae family, and to assess their in vitro antioxidant and anti-inflammatory activities. The phenolic profiles of the DWWs were determined by HPLC-DAD and HPLC-ESI/MS. Free radical scavenging ability, oxygen radical antioxidant capacity and su…

IAEA Contribution to Nanosized Targeted Radiopharmaceuticals for Drug Delivery.

2022

The rapidly growing interest in the application of nanoscience in the future design of radiopharmaceuticals and the development of nanosized radiopharmaceuticals in the late 2000′s, resulted in the creation of a Coordinated Research Project (CRP) by the International Atomic Energy Agency (IAEA) in 2014. This CRP entitled ‘Nanosized delivery systems for radiopharmaceuticals’ involved a team of expert scientist from various member states. This team of scientists worked on a number of cutting-edge areas of nanoscience with a focus on developing well-defined, highly effective and site-specific delivery systems of radiopharmaceuticals. Specifically, focus areas of various teams of scientists com…

Radiolabeling of Nanoparticles and Polymers for PET Imaging

2014

Nanomedicine has become an emerging field in imaging and therapy of malignancies. Nanodimensional drug delivery systems have already been used in the clinic, as carriers for sensitive chemotherapeutics or highly toxic substances. In addition, those nanodimensional structures are further able to carry and deliver radionuclides. In the development process, non-invasive imaging by means of positron emission tomography (PET) represents an ideal tool for investigations of pharmacological profiles and to find the optimal nanodimensional architecture of the aimed-at drug delivery system. Furthermore, in a personalized therapy approach, molecular imaging modalities are essential for patient screeni…

Improvements and applications of the elements of prototype-based clustering

2018

Clustering or cluster analysis is an essential part of data mining, machine learning, and pattern recognition. The most popularly applied clustering methods are partitioning-based or prototype-based methods. Prototype-based clustering methods usually have easy implementability and good scalability. These methods, such as K-means clustering, have been used for different applications in various fields. On the other hand, prototype-based clustering methods are typically sensitive to initialization, and the selection of the number of clusters for knowledge discovery purposes is not straightforward. In the era of big data, in high-velocity, ever-growing datasets, which can also be erroneous, outl…

La desheredación del menor de edad

2021

This work aims to answer the eternal question of the disinheritance of the child under legal age. To this end, we will approach the institute of disinheritance, its foundation and its jurisprudential evolution. We will also address the capacity and responsibility of the child under legal age and the emancipated minor. Subsequently, we will carry out the study of the disinheritance of the child under legal age, subject to the whim of the specific disinherited causes, since each of the causes provided for in art. 853 Spanish Civil Code are endowed with their own idiosyncrasy, being very complicated, if not impossible, to deal with the subject of this work apart from the vicissitudes that can …

Società in house e crisi d’impresa alla luce dell’art. 14 TUSP

2021

The article analyzes the content of Article 14 TUSP (i.e. the Italian Law on Publicly Owned Companies), affirming its applicability also to in-house companies. Particular attention is paid to the regulation of the recovery / restructuring plans mentioned therein and to the interrelationships existing between the latter and the similar (but different) institution of the “certified recovery plans” mentioned by the current Article 67, paragraph 3, lett. d), Bankruptcy Law. Further considerations are addressed to the possibility that theabovementioned recovery plan contemplates the sale of the public shareholdings held by the parent company in the in-house company. Finally, a concise concluding…