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showing 10 items of 6927 documents
Sulfonamide moiety as "molecular chimera" in the design of new drugs.
2021
Background: The -SO2NH- group is of great significance in modern pharmaceutical use since, in sulfa-drugs, it is possible to introduce easily chemical modifications, and even small changes may lead to an improved version of an already existing drug. Objective: This paper aims to describe updated information in the sulfonamide field with a particular focus on new mechanisms of action, especially if discovered by employing computational approaches. Methods: Research articles that focused on the use of the sulfonamide moiety for the design, synthesis, and in vitro/in vivo tests of various diseases were collected from various search engines like PubMed, Science Direct, Google Scholar, and Scop…
Changes in Body Composition, Energy Metabolites and Electrolytes During Winter Survival Training in Male Soldiers
2022
The aim of this study was to examine changes in body composition, energy metabolites and electrolytes during a 10-day winter survival training period. Two groups of male soldiers were examined: the REC group (n = 26; age 19.7 ± 1.2 years; BMI 23.9 ± 2.7) had recovery period between days 6 and 8 in the survival training, whereas the EXC group (n = 42; age 19.6 ± 0.8 years; BMI 23.1 ± 2.8) did not. The following data were collected: body composition (bioimpedance), energy balance (food diaries, heart rate variability measurements), and biomarkers (blood samples). In survival training, estimated energy balance was highly negative: −4,323 ± 1,515 kcal/d (EXC) and −4,635 ± 1,742 kcal/d (REC). Be…
Physiological and physical performance changes during a 20-day winter military training course and its subsequent 10-day recovery period
2023
The present study investigated physiological, mental and physical performance changes during a 20-day winter military training course and the following 10-day recovery period. Fifty-eight (age 19 ± 1 years, height 182 ± 6 cm, body mass 78.5 ± 7.2 kg) male soldiers volunteered. Body composition, serum biomarker levels and performance tests were measured four times during the study. In addition, questionnaires were collected daily for subjective stress and rate of perceived exertion. The course induced significant declines in body (−3.9%, p < 0.05) and fat mass (−31.6%, p < 0.05) as well as in all assessed physical performance variables (−9.2 - −20.2%, p < 0.05), testosterone (−73.7%, p < 0.0…
Acute Neuromuscular and Hormonal Responses to Power, Strength, and Hypertrophic Protocols and Training Background
2022
This study investigated how two slightly different athlete groups would differ in acute neuromuscular and endocrine responses to specific resistance exercise loadings and recovery compared to untrained participants. Power athletes (PA, n = 8), strength athletes (SA, n = 8) and non-athletes (NA, n = 7) performed power (PL, 7 × 6 × 50% of 1RM), maximal strength (MSL, 7 × 3 × 3RM), and hypertrophic (HL, 5 × 10 × 10RM) loadings in Smith-machine back-squat. Neuromuscular performance, serum testosterone, growth hormone, and cortisol concentrations, and blood lactate (BL) were measured before (Pre), at Mid and after (Post) loading, and after recovery for 24 and 48 h. All loadings led to acute decr…
Neuromuscular Performance and Hormonal Profile During Military Training and Subsequent Recovery Period
2019
Introduction Military training loads may induce different physiological responses in garrison and field training and only a little is known about how short-time recovery, lasting a few days, affects neuromuscular fitness and hormonal profile. This study aimed to investigate the effects of garrison and field military service on neuromuscular performance and hormonal profile and to evaluate the effects of a 3-day recovery on those factors. Methods Twenty healthy male soldiers (20 ± 1 years) participated in the study, which consisted of 4 days of garrison training [days (D) 1–4] and 7 days of military field training (Days 5–12) followed by a 3-day recovery period (Day 15). Serum hormone concen…
Individualized Endurance Training Based on Recovery and Training Status in Recreational Runners
2022
Purpose Long-term development of endurance performance requires a proper balance between strain and recovery. While responses and adaptations to training are highly individual, this study examined whether individually-adjusted endurance training based on recovery and training status would lead to greater adaptations compared to a predefined program. Methods Recreational runners were divided into predefined (PD, n = 14) or individualized (IND, n = 16) training groups. In IND, the training load was decreased, maintained or increased twice a week based on nocturnal heart rate variability, perceived recovery, and heart rate-running speed index. Both groups performed three-week preparatory, six-…
A one-pot method to enhance dissolution rate of low solubility drug molecules using dispersion polymerization in supercritical carbon dioxide
2009
The Role of Surface Acting in the Relationship between Job Stressors, General Health and Need for Recovery Based on the Frequency of Interactions at …
2022
The aim of the study was to verify whether the frequency of face-to-face interactions with the public at work can reveal differences in how people react to emotional regulation demands. In particular, we investigated the mediating role of surface acting (a strategy of dealing with emotional dissonance) in the relationship between two typical job stressors (workload and mental load) and two outcomes closely related to work-related well-being: employees’ general health and the need for recovery. Prior studies investigating the detrimental effects of emotional dissonance mostly focused on service workers. However, in light of a survey conducted by the European Agency for Safety and Health at W…
Heart rate recovery after maximal and submaximal exercise
2012
Pasi Karjalainen (2012). Heart rate recovery after maximal and submaximal exercise. Department of Biology of Physical Activity, University of Jyväskylä, Master thesis in exercise physiology, 76 pages. Heart rate recovery (HRR) after exercise reflects autonomic control of the heart. Heart rate recovery (HRR) has shown to have prognostic value among asymptomatic populations and patients with diseases. In addition, changes in HRR may reflect the effects of training load. The role of parasympathetic reactivation in decrease of heart rate (HR) is known to be strong immediately after the cessation of exercise. It is also shown that HRR is affected by the activity of the sympathetic system that is…
Post-exercise heart rate variability : a new approach to evaluation of exercise-induced physiological training load
2015
To improve maximal endurance performance, an optimal physiological training load, i.e. the balance between exercise and recovery, is required. In general, the goal of a single endurance exercise session is to transiently disturb body homeostasis after which a so-called supercompensation, an improvement in performance, can occur if the recovery period is adequate. The physical training load of a single exercise session consists of the combination of exercise intensity and duration. At the present time, there is no single tool to quantify the amount of disturbance of homeostasis that is equal to physiological training load of a single exercise session. Heart rate variability (HRV), the change…