Search results for "vessels"
showing 10 items of 348 documents
Oral microcirculation observed in vivo by videocapillaroscopy: a review
2009
Capillaroscopy is a non-invasive diagnostic technique that is fundamental in viewing peripheral circulation and in studying microangiopathies. The morphological study of microcirculat ion is of fundamental importance, mainly because the microvascular bed is directly involved in the etiopathogenesis of autoimmune disorders and acute and chronic inflammatory pathological conditions. The value of capillaroscopic investigation as a diagnostic means in cases of peripheral microcirculation disorders has been confirmed by numerous studies. Other studies used capillaroscopic investigations to evaluate microcirculation damage not as a complication of disease (diabetes), but as its initial stage, and…
Budd-Chiari Syndrome: Spectrum of Imaging Findings
2007
OBJECTIVE: The objective of our study was to illustrate the imaging findings of Budd-Chiari syndrome, including CT, MRI, sonographic, and angiographic findings. CONCLUSION: The key imaging findings in Budd-Chiari syndrome are occlusion of the hepatic veins, inferior vena cava, or both; caudate lobe enlargement; inhomogeneous liver enhancement; and the presence of intrahepatic collateral vessels and hypervascular nodules. Awareness of these findings is important for early diagnosis and appropriate treatment.
Caffeine and cardiovascular diseases: critical review of current research.
2015
Caffeine is a most widely consumed physiological stimulant worldwide, which is consumed via natural sources, such as coffee and tea, and now marketed sources such as energy drinks and other dietary supplements. This wide use has led to concerns regarding the safety of caffeine and its proposed beneficial role in alertness, performance and energy expenditure and side effects in the cardiovascular system. The question remains "Which dose is safe?", as the population does not appear to adhere to the strict guidelines listed on caffeine consumption. Studies in humans and animal models yield controversial results, which can be explained by population, type and dose of caffeine and low statistica…
EGFL7 ligates αvβ3 integrin to enhance vessel formation
2013
Angiogenesis, defined as blood vessel formation from a preexisting vasculature, is governed by multiple signal cascades including integrin receptors, in particular integrin αVβ3. Here we identify the endothelial cell (EC)-secreted factor epidermal growth factor-like protein 7 (EGFL7) as a novel specific ligand of integrin αVβ3, thus providing mechanistic insight into its proangiogenic actions in vitro and in vivo. Specifically, EGFL7 attaches to the extracellular matrix and by its interaction with integrin αVβ3 increases the motility of EC, which allows EC to move on a sticky underground during vessel remodeling. We provide evidence that the deregulation of EGFL7 in zebrafish embryos leads …
Lymphatic vessels are present in human saccular intracranial aneurysms
2022
AbstractSaccular intracranial aneurysm (sIA) rupture leads to subarachnoid haemorrhage and is preceded by chronic inflammation and atherosclerotic changes of the sIA wall. Increased lymphangiogenesis has been detected in atherosclerotic extracranial arteries and in abdominal aortic aneurysms, but the presence of lymphatic vessels in sIAs has remained unexplored. Here we studied the presence of lymphatic vessels in 36 intraoperatively resected sIAs (16 unruptured and 20 ruptured), using immunohistochemical and immunofluorescence stainings for lymphatic endothelial cell (LEC) markers. Of these LEC-markers, both extracellular and intracellular LYVE-1-, podoplanin-, VEGFR-3-, and Prox1-positive…
The effects of ergot and non-ergot-derived dopamine agonists in an experimental mouse model of endometriosis
2011
Implantation of a retrogradely shed endometrium during menstruation requires an adequate blood supply, which allows the growth of endometriotic lesions. This suggests that the development of endometriosis can be impaired by inhibiting angiogenesis. The growth of endometriotic foci is impaired by commercial oncological antiangiogenic drugs used to block vascular endothelial growth factor (VEGF) signaling. The dopamine agonist cabergoline (Cb2) inhibits the growth of established endometriosis lesions by exerting antiangiogenic effects through VEGFR2 inactivation. However, the use of ergot-derived Cb2 is associated with an increased incidence of cardiac valve regurgitation. To evaluate the pot…
Lymphatic endothelial progenitors bud from the cardinal vein and intersomitic vessels in mammalian embryos.
2012
Abstract The lymphatic vasculature preserves tissue fluid balance by absorbing fluid and macromolecules and transporting them to the blood vessels for circulation. The stepwise process leading to the formation of the mammalian lymphatic vasculature starts by the expression of the gene Prox1 in a subpopulation of blood endothelial cells (BECs) on the cardinal vein (CV) at approximately E9.5. These Prox1-expressing lymphatic endothelial cells (LECs) will exit the CV to form lymph sacs, primitive structures from which the entire lymphatic network is derived. Until now, no conclusive information was available regarding the cellular processes by which these LEC progenitors exit the CV without co…
Mixing dynamics in uncovered unbaffled stirred tanks
2014
Abstract The present work is aimed at providing experimental information on mixing rates in an unbaffled vessel under free surface vortexing conditions. The planar laser induced fluorescence (PLIF) technique was used for measuring the dispersion dynamics of a passive tracer over a vertical section of the vessel. In agreement with the quite scant literature information available for these systems, results confirm the existence of two well defined, partially segregated, zones that give rise to a double mixing dynamics behavior. A suitable mixing time definition is proposed and applied to a number of experimental runs with different stirrer geometries and agitation speeds. Results confirm that…
Free-surface shape in unbaffled stirred vessels: Experimental study via digital image analysis
2013
There is a growing interest in using unbaffled stirred tanks for addressing a number of processing needs such as low shear damage (sensitive biocultures), low attrition (solid–liquid applications), deep-cleaning/sterilization (pharmaceutical applications). The main feature of uncovered, unbaffled stirred tanks is highly swirling motion of the fluid that results in a deformation of the free liquid surface. At sufficiently high agitation speeds the resulting whirlpool reaches the impeller and gives rise to a gas–liquid dispersion, so leading to the formation of a dispersion without the use of gas-sparger; the so-called self-inducing operation of the vessel. In this work, digital image analysi…
Anti-angiogenic drug loaded liposomes: Nanotherapy for early atherosclerotic lesions in mice.
2018
Este artículo se encuentra disponible en la página web de la revista en la siguiente URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0190540 También participan en la elaboración de este artículo científico: Aracely Calatayud-Pascual, Alicia López-Castellano, Elena P. Albelda, Enrique García-España, Luis Martí-Bonmatí, Juan C. Frias y M. Teresa Albelda. Fumagillin-loaded liposomes were injected into ApoE-KO mice. The animals were divided into several groups to test the efficacy of this anti-angiogenic drug for early treatment of atherosclerotic lesions. Statistical analysis of the lesions revealed a decrease in the lesion size after 5 weeks of treatment.