Search results for "video"
showing 10 items of 1348 documents
Didactic video as an alternative to in vivo assays in practical lessons of pharmacology
2010
La Farmacología es una ciencia eminentemente práctica, en la que tiene gran relevancia la investigación "in vivo" con animales de experimentación. Los conocimientos impartidos en las clases teóricas, seminarios y tutorías, se completan con la enseñanza en las sesiones prácticas. Sin embargo, algunos aspectos importantes de esta enseñanza práctica, que incluyen la realización de ensayos “in vivo”, resulta problemático impartirlos correctamente con la normativa actual sobre la utilización de animales de laboratorio. Por ello, nos planteamos la realización de unos vídeos demostrativos de las técnicas experimentales utilizadas en algunas de las sesiones prácticas de las asignaturasde Farmacolog…
The α1B-adrenoceptor subtype mediates adrenergic vasoconstriction in mouse retinal arterioles with damaged endothelium
2014
Background and Purpose The α1-adrenoceptor family plays a critical role in regulating ocular perfusion by mediating responses to catecholamines. The purpose of the present study was to determine the contribution of individual α1-adrenoceptor subtypes to adrenergic vasoconstriction of retinal arterioles using gene-targeted mice deficient in one of the three adrenoceptor subtypes (α1A-AR−/−, α1B-AR−/− and α1D-AR−/− respectively). Experimental Approach Using real-time PCR, mRNA expression for individual α1-adrenoceptor subtypes was determined in murine retinal arterioles. To assess the functional relevance of the three α1-adrenoceptor subtypes for mediating vascular responses, retinal vascular…
Field-induced ordering phenomena and non-local elastic compliance in two-dimensional colloidal crystals
2008
Ordering phenomena in colloidal dispersions exposed to external one-dimensional, periodic fields or under confinement are studied systematically by Monte Carlo computer simulations. Such systems are useful models for the study of monolayers on a substrate. We find that the interaction with a substrate potential completely changes the miscibility of a binary, hard disc mixture at low external field amplitudes. The underlying ordering mechanisms leading to this laser-induced de-mixing differ, depending on which components interact with the substrate potential. Generic effects of confinement on crystalline order in two dimensions are studied in a model system of point particles interacting via…
A comparison of spreading and motility behaviour of 8701-BC breast carcinoma cells on type I, I-trimer and type V collagen substrata. Evidence for a …
1991
Ductal infiltrating carcinoma (d.i.c.) of human breast is a highly invasive neoplasm characterized by enhanced deposition of collagen. Paradoxically, enhanced collagen deposition is not correlated with inhibition of the migration of tumour cells into the host tissue. d.i.c. is characterized by the reappearance of ‘embryonic’ type I-trimer collagen and an increase in type V collagen content in the matrix. The effects of these two collagen types were compared with type I collagen as culture substrata on the spreading pattern, cytoskeletal organization and motile behaviour of 8701-BC breast carcinoma cells using rhodamine-phalloidin staining, a DNAase I-competition assay, scanning electron mic…
Surface investigation and aluminum oxide estimation on test filters for the ATHENA X-IFU and WFI detectors
2016
The ATHENA mission provides the demanded capabilities to address the ESA science theme "Hot and Energetic Universe". Two complementary instruments are foreseen: the X-IFU (X-ray Integral Field Unit) and WFI (Wide Field Imager). Both the instruments require filters to avoid that the IR radiation heats the X-IFU cryogenic detector and to protect the WFI detector from UV photons. Previous experience on XMM filters recommends to employ bilayer membrane consisting of aluminum deposited on polyimide. In this work, we use the X-ray Photoelectron Spectroscopy (XPS) to quantify the native aluminum oxide thickness that affects the spectral properties of the filter. The estimation of the oxide thickne…
Analysis of a multi-wavelength time-resolved observation of a coronal loop
2005
Several items on the diagnostics and interpretation of coronal loop observations are under debate. In this work, we analyze a well-defined loop system detected in a time-resolved observation in several spectral bands. The dataset includes simultaneous images in the TRACE 171 A, 195 A and 284 A bands, and Yohkoh/SXT, and two rasters taken with SoHO/CDS in twelve relevant lines. The loop is initially best visible in the TRACE 195 A filter band, and later in the 171 A filter band, with correspondence with the CDS raster images at log T \~ 6.0-6.1. We have taken as pixel-by-pixel background the latest TRACE, Yohkoh and CDS images where the loop has faded out. We examine the loop morphology evol…
Solc filters in a reflective geometry
2017
We present the realization of a bulk optics birefringent Solc filter in a reflective geometry. This geometry reduces by half the number of required retarders, ensures the same spectral retardance function in pairs of retarders, and helps to make more compact filters. The key element is a quarter-wave Fresnel rhomb located in between the set of retarders and a mirror. Two cases are considered: the first Solc filter uses multiple-order quartz retarders, and the second one uses two liquid-crystal retarders. The latter has the advantage of being tunable via an applied voltage. Experimental results show how to filter the spectral content of a supercontinuum laser.
Strain pattern in supercooled liquids
2016
Investigations of strain correlations at the glass transition reveal unexpected phenomena. The shear strain fluctuations show an Eshelby-strain pattern ($\,\sim \cos{(4\theta)}/r^2\,$), characteristic for elastic response, even in liquids at long times [1]. We address this using a mode-coupling theory for the strain fluctuations in supercooled liquids and data from both, video microscopy of a two-dimensional colloidal glass former and simulations of Brownian hard disks. We show that long-ranged and long-lived strain-signatures follow a scaling law valid close to the glass transition. For large enough viscosities, the Eshelby-strain pattern is visible even on time scales longer than the stru…
Bound-state dark matter and Dirac neutrino mass
2018
We propose a simple theory for the idea that cosmological dark matter (DM) may be present today mainly in the form of stable neutral hadronic thermal relics. In our model neutrino masses arise radiatively from the exchange of colored DM constituents, giving a common origin for both dark matter and neutrino mass. The exact conservation of $B-L$ symmetry ensures dark matter stability and the Dirac nature of neutrinos. The theory can be falsified by dark matter nuclear recoil direct detection experiments, leading also to possible signals at a next generation hadron collider.
Preliminary Mechanical Characterization of Thermal Filters for the X-IFU Instrument on Athena
2018
The X-ray Integral Field Unit (X-IFU) is one of the two instruments of the Athena astrophysics space mission approved by ESA in the Cosmic Vision Science Program. The X-IFU consists of a large array of TES microcalorimeters that will operate at ~ 50 mK inside a sophisticated cryostat. A set of thin filters, highly transparent to X-rays, will be mounted on the cryostat thermal shields in order to attenuate the IR radiative load, to attenuate RF electromagnetic interferences, and to protect the detector from contamination. In this paper, we present the current thermal filters design, describe the filter samples developed/procured so far, and present preliminary results from the ongoing charac…