Search results for "vins"
showing 10 items of 107 documents
Serum follistatin in patients with prostate cancer metastatic to the bone
2010
The clinical significance of circulating fol- listatin (FLST), an inhibitor of the multifunctional cytokine activin A (Act A), was investigated in patients with prostate cancer (PCa). The serum concentrations of this molecule were determined by an enzyme-linked immunosorbent assay (ELISA) in PCa patients with (M?) or without (M0) bone metastases, in patients with benign prostate hyperplasia (BPH) and in healthy sub- jects (HS). The effectiveness of FLST in detecting PCa patients with skeletal metastases was determined by the receiver operating characteristic (ROC) curve analysis. Serum FLST was significantly higher in PCa patients than in BPH patients (P = 0.001) or HS (P = 0.011). Converse…
Muscle NAD+ depletion and Serpina3n as molecular determinants of murine cancer cachexia—the effects of blocking myostatin and activins
2020
Objective Cancer cachexia and muscle loss are associated with increased morbidity and mortality. In preclinical animal models, blocking activin receptor (ACVR) ligands has improved survival and prevented muscle wasting in cancer cachexia without an effect on tumour growth. However, the underlying mechanisms are poorly understood. This study aimed to identify cancer cachexia and soluble ACVR (sACVR) administration-evoked changes in muscle proteome. Methods Healthy and C26 tumour-bearing (TB) mice were treated with recombinant sACVR. The sACVR or PBS control were administered either prior to the tumour formation or by continued administration before and after tumour formation. Muscles were an…
Upregulation of activin-B and follistatin in pulmonary fibrosis: a translational study using human biopsies and a specific inhibitor in mouse fibrosi…
2014
Background: Activins are members of the TGF-ß superfamily of growth factors. First, we identified by expression array screening that activin-B and follistatin are upregulated in human idiopathic pulmonary fibrosis (IPF). Next, we wanted to clarify their specific role in lung fibrosis formation. Methods: We used specific antibodies for activin-A and -B subunits and follistatin to measure and localize their levels in idiopathic pulmonary fibrosis and control lung biopsies. To inhibit activin signaling, we used soluble activin type IIB receptor fused to the Fc portion of human IgG1 (sActRIIB-Fc) in two different mouse models of pulmonary fibrosis. Results: Activin-B and follistatin mRNA levels…
Muscle protein synthesis, mTORC1/MAPK/Hippo signaling, and capillary density are altered by blocking of myostatin and activins
2012
Loss of muscle mass and function occurs in various diseases. Myostatin blocking can attenuate muscle loss, but downstream signaling is not well known. Therefore, to elucidate associated signaling pathways, we used the soluble activin receptor IIb (sActRIIB-Fc) to block myostatin and activins in mice. Within 2 wk, the treatment rapidly increased muscle size as expected but decreased capillary density per area. sActRIIB-Fc increased muscle protein synthesis 1–2 days after the treatment correlating with enhanced mTORC1 signaling (phosphorylated rpS6 and S6K1, r = 0.8). Concurrently, increased REDD1 and eIF2Bε protein contents and phosphorylation of 4E-BP1 and AMPK was observed. In contrast, pr…
Postexercise myostatin and activin IIb mRNA levels: effects of strength training.
2007
ABSTRACTHULMI, J. J., J. P. AHTIAINEN, T. KAASALAINEN, E. PO¨LLA¨NEN, K. HA¨KKINEN, M. ALEN, H. SELA¨NNE, V. KOVANEN,and A. A. MERO. Postexercise Myostatin and Activin IIb mRNA Levels: Effects of Strength Training. Med. Sci. Sports Exerc., Vol.39, No. 2, pp. 289–297, 2007. Purpose: Muscle hypertrophy is likely to result from the cumulative effects of repeated bouts ofresistance exercise (RE) on postexercise molecular responses. Therefore, we determined muscle growth- and regeneration-relatedmRNA expression in response to a single RE bout both before and after a strength-training (ST) period. By means of this novellongitudinal setting, we examined whether postexercise gene expression at the …
Prevention of chemotherapy‐induced cachexia by ACVR2B ligand blocking has different effects on heart and skeletal muscle
2017
Background Toxicity of chemotherapy on skeletal muscles and the heart may significantly contribute to cancer cachexia, mortality, and decreased quality of life. Doxorubicin (DOX) is an effective cytostatic agent, which unfortunately has toxic effects on many healthy tissues. Blocking of activin receptor type IIB (ACVR2B) ligands is an often used strategy to prevent skeletal muscle loss, but its effects on the heart are relatively unknown. Methods The effects of DOX treatment with or without pre-treatment with soluble ACVR2B-Fc (sACVR2B-Fc) were investigated. The mice were randomly assigned into one of the three groups: (1) vehicle (PBS)-treated controls, (2) DOX-treated mice (DOX), and (3) …
Le metamorfosi del corale "Vom Himmel hoch da komm ich her" fra Lutero, Bach e Stravinsky
2020
Il corale matalizio "Vom Himmel hoch da komm ich her" (Dall'alto dei cieli io giungo) è stato realizzato da Martin Lutero sulla base della melodia popolare "Ich komm aus fremden Landen her" e fu pubblicato per la prima volta a Wittenberg nel 1535. Assai diffuso in tutta l'area culturale tedesca, questo brano è stato ripreso, tra gli altri, anche da J.S. Bach, sia nel "Weinachts-Oratorium" BWV 248 che nelle "Canonische Veraenderungen" per organo BWV 796 e 796a. Il saggio ricostruisce il contesto in cui vide la luce la versione originale del canto natalizio e si sofferma sull'interesse di Bach per la numerologia e sulle "citazioni nascoste" in molte sue opere, incluse le "Veraenderungen" sul …
Musica e architettura. Le opere di Igor Stravinsky per la basilica di San Marco a Venezia
2019
Il 13 settembre 1956, Stravinsky diresse nella basilica di San Marco a Venezia la prima esecuzione del "Canticum Sacrum" (1955), insieme con le "Variazioni-corali sulla canto natalizio Vom Himmel hoch…" (1955-56). Il "Canticum" era stato realizzato su commissione del Festival delle Biennale e costituisce un esempio dell'approccio del compositore alla tecnica dodecafonica. Le "Variazioni-corali" presentano quasi il medesimo organico del "Canticum" e sono invece da considerarsi come una sorta di ripensamento creativo delle "Variazioni canoniche" BWV 796-796a di Johann Sebastian Bach. September 13th 1956, Stravinsky conducted at the basilica of St. Mark in Venice the first performance of the "…
Recens. a Le “poetriae” del Medioevo latino. Modelli, fortuna, commenti, a cura di G.C. Alessio - D. Losappio, Venezia, Edizioni Ca' Foscari, 2017
2019
Recens. al vol. Le “poetriae” del Medioevo latino. Modelli, fortuna, commenti, a cura di G.C. Alessio - D. Losappio, pubblicato a Venezia nel 2017 dalle edizioni dell'Università di Venezia "Ca' Foscari".
Clustering of textual networks: analysing open-ended questions in text data of the perception of minerality in wine
2014
International audience; Open-ended questions are commonly used in sensory analyses, and are usually dealt with by correspondence analysis (CA) of the term-respondent matrix. CA is apt in detecting strong associations between terms and groups of respondents, but less so when the questions are interpreted differently among respondents and, thus, seem to open a polysemic space for the answers. Also, CA offers little flexibility in filtering out irrelevant textual structure, or in controlling the relative contribution of rare versus frequent terms in the overall analysis. This contribution presents methodological extensions of CA together with application on a survey of 1900 responses bearing u…