Search results for "virus"
showing 10 items of 5024 documents
Bleomycin, a selective inhibitor of DNA-dependent DNA polymerase from oncogenic RNA viruses.
1972
Abstract Bleomycin, an antibiotic, inhibits the DNA-dependent DNA polymerase from Rauscher murine leukemia virus. Higher concentrations of BLM ∗ are required to inhibit it's RNA-dependent DNA polymerase. These inhibition effects of the non-competitive type are not altered by preincubation of the DNA with BLM. Under comparable conditions neither the DNA-dependent DNA polymerase activity from E. coli and mouse liver nor the DNA-dependent RNA polymerase activity from mouse lymphoma cells are affected by BLM.
Bleomycin: Action on growth of oncogenic RNA viruses and on cell transformation
1975
Bleomycin (BLM) inhibits cell proliferation of noninfected chick embryo fibroblasts by blocking their DNA synthesis selectively. Chick embryo fibroblasts have beentransformed by Schmidt-Ruppin D strain of Rous Sarcoma Virus. Transformation has been determined by a focus assay. Foci formation is strongly reduced by BLM. Virus replication is inhibited by BLM in growing and confluent monolayer cells. This result might be explained by the observation that this drug reduces proliferation of growing and of confluent monolayer cells very sensitively. During the first 24 hours after infection the BLM inhibitory effect is more pronounced than in the case of BLM-application during the period 24--48 h…
Understanding Consumers’ Online Shopping Behavior during the Covid-19 Pandemic – Empirical Research
2020
The COVID-19 pandemic has impacted our daily behavior, from interactions with friends, colleagues, and family, to safety measures and working. Additionally, this pandemic has dramatically changed consumers’ shopping behavior. The purpose of this research paper is to examine the impact of Covid-19 pandemic on consumer behavior. Thus, this paper proposes a new model that incorporates three variables: attitude for online shopping during the COVID-19 pandemic, budget considerations during the COVID-19 pandemic, and future behavioral intention after the COVID-19 pandemic. This study’s main research approach is a quantitative survey and examination using a sample of Romanian consumers. Additional…
Demographic inequalities as determinants and consequences of the COVID-19 pandemic in Latvia
2021
Since early March 2020 Latvia is fighting the COVID-19 pandemic. Lessons learned from this crisis will be instrumental in shaping future public health policy. Any policy response to the pandemic must be tailored to the particular risks within population in order to avoid the unnecessary social and economic damage on a national and international scale. Available literature on the topic highlights region-specific demographic factors associated with elevated population vulnerability to the effects of the COVID-19 pandemic. This study aims to ascertain the role of a pre-existing demographic inequalities in Latvia in the onset and progression of COVID-19 pandemic and lay groundwork for projectin…
Die durch COVID-19 infizierte Pressesprache. Coronavirus in sprachlichen Bildern
2022
The coranavirus pandemic has changed not only the lives of people around the world, but also the language they use. This paper aims to analyse the metaphors used to describe the SARS-CoV-2 virus and the COVID-19 disease it causes. It furthermore indicates the extent to which these metaphors determine how the pandemic is portrayed in press articles. The cognitive picture of the coronavirus (or pandemic) will be presented with reference to conceptual metaphors, as these are understood by Lakoff and Johnson (2014) and Jäkel (2003). The analysis considers the timeframe that starts with the outbreak of the pandemic in December 2019 and ends in March 2022, with the resulting corpus including 278 …
contratto e covid-19
2020
si indaga sul rapporto contrattuale per coglierne sapientemente la forza di resistenza, ma anche il lato più debole e vulnerabile rispetto agli effetti prodotti dall’emergenza epidemiologica
I corpi del virus
2020
In un articolo recentemente uscito in italiano, Bruno Latour spiega che il nuovo coronavirus illustra in modo eclatante come gli attori non umani irrompano nei nostri spazi collettivi esigendo profonde trasformazioni (e invitando a ripensare così noi stessi al loro interno). Al momento è impossibile valutare questi cambiamenti sul lungo periodo. È chiaro però che SARS-CoV-2 ha avuto subito effetti visibilissimi sulle istituzioni che danno forma al nostro universo collettivo: mercati finanziari, filiere produttive, sistemi sanitari, regolamenti, lockdown. Mi sembra che il luogo di convergenza di questi ambiti tematici sia il corpo, figura in cui si incrociano le isotopie mediche, economiche,…
Glucocorticoid excess and COVID-19 disease
2020
AbstractThe pandemic of coronavirus disease (COVID-19), a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is causing high and rapid morbidity and mortality. Immune system response plays a crucial role in controlling and resolving the viral infection. Exogenous or endogenous glucocorticoid excess is characterized by increased susceptibility to infections, due to impairment of the innate and adaptive immune system. In addition, diabetes, hypertension, obesity and thromboembolism are conditions overrepresented in patients with hypercortisolism. Thus patients with chronic glucocorticoid (GC) excess may be at high risk of developing COVID-19 infection with a sever…
Destin du covid-19
2020
International audience; La lutte moderne contre les épidémies privilégie le dépistage rapide, le diagnostic, les soins et la quarantaine des malades plutôt que le confinement général de la population. Comparée aux pics de mortalité du passé récent, celle due au covid-19 ne paraît pas anormale mais elle s'est localisée dans quelques régions et grandes agglomérations. Deux cas emblématiques sont évoqués : le paquebot de croisière Diamond Princess et le porte-avions Charles de Gaulle. Le pronostic vital ne semble engagé que pour des sujets dont le système immunitaire est affaibli (comme le grand âge). En revanche, la population en bonne santé ne paraît pas en danger d'autant plus qu'un traitem…
Risk of Virus Contamination Through Surgical Smoke During Minimally Invasive Surgery: A Systematic Review of the Literature on a Neglected Issue Revi…
2020
Abstract Context The coronavirus disease 2019 (COVID-19) pandemic raised concerns about the safety of laparoscopy due to the risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) diffusion in surgical smoke. Although no case of SARS-CoV-2 contagion related to surgical smoke has been reported, several international surgical societies recommended caution or even discouraged the use of a laparoscopic approach. Objective To evaluate the risk of virus spread due to surgical smoke during surgical procedures. Evidence acquisition We searched PubMed and Scopus for eligible studies, including clinical and preclinical studies assessing the presence of any virus in the surgical smoke fr…