Search results for "virus"
showing 4 items of 5024 documents
Assessment of Knowledge, Attitudes, and Propensity towards HPV Vaccine of Young Adult Students in Italy
2020
Background: Human Papillomavirus (HPV) is a common sexually transmitted infection (STI), representing the main cause of genital warts and cervical cancer. This cross-sectional study evaluated knowledge and attitudes about HPV infection, related diseases, and prevention and propensity towards HPV vaccine among undergraduate students. Methods: An online and written survey about HPV and its prevention, targeted to young adults of both genders, was addressed to students attending health sciences and other schools at Universities of Genoa and Bari. Results: The overall median knowledge and attitude scores were 56.3% (25&ndash
Modeling multipartite virus evolution: the genome formula facilitates rapid adaptation to heterogeneous environments
2020
Multipartite viruses have two or more genome segments, and package different segments into different particle types. Although multipartition is thought to have a cost for virus transmission, its benefits are not clear. Recent experimental work has shown that the equilibrium frequency of viral genome segments, the setpoint genome formula (SGF), can be unbalanced and host-species dependent. These observations have reinvigorated the hypothesis that changes in genome-segment frequencies can lead to changes in virus-gene expression that might be adaptive. Here we explore this hypothesis by developing models of bipartite virus infection, leading to a threefold contribution. First, we show that th…
Hroniska C hepatīta ārstēšanas efektivitāte ar tiešās darbības antivirālajiem medikamentiem: reālas dzīves dati
2017
Darba aktualitāte: Hronisks C hepatīts ir globāla problēma jau daudzus gadus. Slimības sākuma stadijā parasti nav simptomu. Pēdējo dažu gadu laikā hroniska C hepatīta ārstēšana ir būtiski izmainījusies un ar jauno medikamentu palīdzību ir iespēja pilnībā izārstēties. Jaunais ārstēšanas kurss ir īsāks, labi panesams un ir augsta efektivitāte. Darba mērkis: Izvērtēt tiešās darbības antivirālo medikamentu efektivitāti un ieguvumus Latvijā. Metodes un materiāli: Tika veikts retrospektīvs pētījums, apkopota informācija no pacientu ambulatorajām kartēm, kuras tika ņemtas no Latvijas Infektoloģijas centra. Pētījumam tik atlasīti pacienti, kuriem ir diagnoze “Hronisks C hepatīts” un kuri ārstēšanā …
An arthritogenic alphavirus uses the α1β1 integrin collagen receptor
2005
Ross River (RR) virus is an alphavirus endemic to Australia and New Guinea and is the aetiological agent of epidemic polyarthritis or RR virus disease. Here we provide evidence that RR virus uses the collagen-binding alpha1beta1 integrin as a cellular receptor. Infection could be inhibited by collagen IV and antibodies specific for the beta1 and alpha1 integrin proteins, and fibroblasts from alpha1-integrin-/- mice were less efficiently infected than wild-type fibroblasts. Soluble alpha1beta1 integrin bound immobilized RR virus, and peptides representing the alpha1beta1 integrin binding-site on collagen IV inhibited virus binding to cells. We speculate that two highly conserved regions with…