Search results for "weakness"
showing 10 items of 198 documents
Clinical and Genetic Aspects of Juvenile Onset Pompe Disease
2021
AbstractLittle is known about clinical symptomatology and genetics of juvenile onset Pompe disease (JOPD). The aims of this study were to analyze how these children are diagnosed, what clinical problems they have, and how phenotype is related to genotype. To accomplish this, we analyzed retrospectively data of 34 patients diagnosed after their first and before completion of their 18th birthday. Median age at diagnosis was 3.9 (range 1.1–17) years. Eight patients (23.5%) developed initial symptoms in the first year, 12 (35%) between 1 and 7 years, and 6 (18%) thereafter. Eight (23.5%) had no clinical symptoms at the time of diagnosis. Indications for diagnostics were a positive family histor…
CLEFT PALATE ONLY: CURRENT CONCEPTS
2017
Cleft palate only (CPO) is one of the most common congenital malformations worldwide. The etiopathogenesis of CPO is not completely understood. Environmental factors, such as smoking, alcohol consumption, intake of drugs during pregnancy, advanced paternal age, have been demonstrated to be a risk of CPO, but conflicting results have also been published. Insufficient intake of folic acid during the pregnancy has been suggested to increase the risk for CPO. The demonstrated risk for siblings and the higher risk for monozygotic twins suggest a genetic etiopathogenesis for CPO. In some cases of CPO a prevalent mode of inheritance has been reported, but oligogenic models with reduced penetrance,…
Between Local and Global: the ‘Ndrangheta’s Drug Trafficking Route
2017
AbstractAccording to the last United Nations Office on Drugs and Crime report (2016), 247 million people aged between 15 and 64 years used drugs at least once in the past year, with cocaine being the best-selling of the goods from the ‘Ndrangheta. In this case, the drugs trade is 60% of the systemic gain due to illicit trafficking that allowed the spreading of the Calabrian criminal organization across five continents. Nevertheless, this sometimes little-known apparently harmless organization, which comes from the Aspromonte heartland in Calabria, was included by the United States in the blacklist of the 75 most dangerous drug-trafficking organizations only in 2008. Therefore, this investig…
Electoral Rules and Proportionality in Spain: Estimating the Impact of some Swedish Rules Through the 2011 Electoral Data
2016
In democratic countries policy making is always framed by many procedures and rules. Some of these rules are particularly critical for allowing more or less proportionality in legislative chambers, though the behavior of political actors also matter. The rules used for technically converting votes into political representatives often exercise such an important role in western countries. In this chapter we provide an estimation of the impact upon proportionality between seats and votes that might have resulted in the 2011 Spanish general elections if some Swedish electoral rules had been applied, ceteris paribus. As we are aware that electoral reforms favouring proportionality may hinder the…
Facial masks in children: the position statement of the Italian pediatric society
2020
AbstractFacial masks may be one of the most cost-effective strategies to prevent the diffusion of COVID 19 infection. Nevertheless, fake news are spreading, alerting parents on dangerous side effects in children, such as hypercapnia, hypoxia, gut dysbiosis and immune system weakness. Aim of the Italian Pediatric Society statement is to face misconception towards the use of face masks and to spread scientific trustable information.
Solar pavements: A critical review
2021
Abstract Resilient, smart and sustainable: these are the keywords for the next generation of road infrastructures. As a renewable and environment-friendly energy harvesting pavement, the concept of a solar pavement has become one of the most researched new highway transportation infrastructures with a goal to transform the road system from the energy consumer to the energy provider, and eliminate or alleviate pollution from the source of energy. At present, the commercial technology through photovoltaic is limited by space installation requirements, which restricts its popularization and application. On the other hand, applying photovoltaic power generation technology to the pavement can pr…
Eco‐tourism Certification – Does it Make a Difference? A Comparison of Systems from Australia, Costa Rica and Sweden
2010
Abstract In the current context of climate change, discussions about tourism sustainability are gaining increased momentum. Over the past decade, some operators worldwide have started to certify their products and services as ecotourism or sustainable tourism. A certification or approval is considered to be a sign of general high product quality as well as an indication of environmentally and socially sound products. In this research note, we examine three different ecotourism certification and approval systems – from Sweden, Costa Rica and Australia. The note is based on a literature review of three different approval systems, conducted parallel to the planning of the Norwegian approval sy…
Qualitative analysis of teachers' written self-reflections after implementation of a social-emotional learning program in Latvia
2016
The aim of the present study was to analyze teachers' written self-reflections after implementation of a social-emotional learning program, which was recently developed specifically for the sociocultural context of Latvia. The goal of the analysis was to examine how teachers reflect upon their own strengths and weaknesses in implementing the program. Participants were 630 classroom teachers (614 female and 16 male) aged 22 to 75 years (M = 45.04, SD = 9.95). Thematic analysis of the teachers' written self-reflections led to five thematic categories: (a) evaluation of pupils' performance, (b) teacher's professional competencies, (c) evaluation of the program, (d) relationship aspects, and (e…
Análisis metodológico del Proyecto PISA como evaluación internacional
2016
En este artículo el objetivo es realizar un análisis global del Proyecto PISA como programa de evaluación internacional. Asimismo, se analizan características metodológicas de los procesos métricos que sustentan los instrumentos que se utilizan en el proyecto: las pruebas de logro y los cuestionarios de contexto. Se identifican las fortalezas y debilidades del proyecto, en diversas áreas, desde el Diseño y validación del proyecto como programa de evaluación internacional, sus usos y modos de comunicación de resultados, hasta las características métricas de sus instrumentos. Se proponen alternativas para optimizar el uso del proyecto en general y en los países involucrados en particular. Se…
Randomized Controlled Trials and real life studies. Approaches and methodologies: a clinical point of view.
2014
Randomized Controlled Trials (RCTs) are the "gold standard" for evaluating treatment outcomes providing information on treatments "efficacy". They are designed to test a therapeutic hypothesis under optimal setting in the absence of confounding factors. For this reason they have high internal validity. The strict and controlled conditions in which they are conducted, leads to low generalizability because they are performed in conditions very different from real life usual care. Conversely, real life studies inform on the "effectiveness" of a treatment, that is, the measure of the extent to which an intervention does what is intended to do in routine circumstances. At variance to RCTs, real …