Search results for "working group"

Developmental terms—some proposals: First report of an International working group

1979

Assessing uncertainties in urban drainage models

2012

The current state of knowledge regarding uncertainties in urban drainage models is poor. This is in part due to the lack of clarity in the way model uncertainty analyses are conducted and how the results are presented and used. There is a need for a common terminology and a conceptual framework for describing and estimating uncertainties in urban drainage models. Practical tools for the assessment of model uncertainties for a range of urban drainage models are also required to be developed. This paper, produced by the International Working Group on Data and Models, which works under the IWA/IAHR Joint Committee on Urban Drainage, is a contribution to the development of a harmonised framewor…

Social support for collaboration and group awareness in life science research teams

2019

Background Next-generation sequencing (NGS) technologies have revolutionarily reshaped the landscape of ’-omics’ research areas. They produce a plethora of information requiring specific knowledge in sample preparation, analysis and characterization. Additionally, expertise and competencies are required when using bioinformatics tools and methods for efficient analysis, interpretation, and visualization of data. These skills are rarely covered in a single laboratory. More often the samples are isolated and purified in a first laboratory, sequencing is performed by a private company or a specialized lab, while the produced data are analyzed by a third group of researchers. In this scenario, …

Openings in technology-mediated business meetings

2015

The prerequisites for opening a meeting, or beginning any kind of interaction for that matter, are participants’ presence and shared orientation towards the situation at hand. This paper analyses how the initial moments of technology-mediated business meetings involving distributed work groups are organized sequentially and multimodally. Drawing on video-recorded meetings in an international company, it documents the multimodal practices used in the process of establishing co-orientation to the shared meeting space and achieving entry into the meeting. The analysis shows that the stepwise unfolding of the opening phase requires the coordination of verbal and bodily conducts as well as the a…

Loss of life expectancy from air pollution compared to other risk factors: a worldwide perspective

2020

Abstract Aims Long-term exposure of humans to air pollution enhances the risk of cardiovascular and respiratory diseases. A novel Global Exposure Mortality Model (GEMM) has been derived from many cohort studies, providing much-improved coverage of the exposure to fine particulate matter (PM2.5). We applied the GEMM to assess excess mortality attributable to ambient air pollution on a global scale and compare to other risk factors. Methods and results We used a data-informed atmospheric model to calculate worldwide exposure to PM2.5 and ozone pollution, which was combined with the GEMM to estimate disease-specific excess mortality and loss of life expectancy (LLE) in 2015. Using this model, …

Genome-wide associations for birth weight and correlations with adult disease

2016

Birth weight (BW) has been shown to be influenced by both fetal and maternal factors and in observational studies is reproducibly associated with future risk of adult metabolic diseases including type 2 diabetes (T2D) and cardiovascular disease. These life-course associations have often been attributed to the impact of an adverse early life environment. Here, we performed a multi-ancestry genome-wide association study (GWAS) meta-analysis of BW in 153,781 individuals, identifying 60 loci where fetal genotype was associated with BW (P < 5 × 10(-8)). Overall, approximately 15% of variance in BW was captured by assays of fetal genetic variation. Using genet…

Sex differences in anthracycline-induced cardiotoxicity: the benefits of estrogens

2019

Anthracyclines are the cornerstone for many oncologic treatments, but their cardiotoxicity has been recognized for several decades. Female subjects, especially before puberty and adolescence, or after menopause, seem to be more at increased risk, with the prognostic impact of this sex issue being less consistent compared to other cardiovascular risk factors. Several studies imply that sex differences could depend on the lack of the protective effect of sex hormones against the anthracycline-initiated damage in cardiac cells, or on differential mitochondria-related oxidative gene expression. This is also reflected by the results obtained with different diagnostic methods, such as cardiovascu…

The EADC-ADNI Harmonized Protocol for manual hippocampal segmentation on magnetic resonance : Evidence of validity

2014

BackgroundAn international Delphi panel has defined a harmonized protocol (HarP) for the manual segmentation of the hippocampus on MR. The aim of this study is to study the concurrent validity of the HarP toward local protocols, and its major sources of variance.MethodsFourteen tracers segmented 10 Alzheimer's Disease Neuroimaging Initiative (ADNI) cases scanned at 1.5 T and 3T following local protocols, qualified for segmentation based on the HarP through a standard web-platform and resegmented following the HarP. The five most accurate tracers followed the HarP to segment 15 ADNI cases acquired at three time points on both 1.5 T and 3T.ResultsThe agreement among tracers was relatively low…

Prevalence of Sarcopenia in Community-Dwelling Older Adults in Valencia, Spain.

2020

This study is an observational and cross-sectional study on the prevalence of sarcopenic disease in 202 autonomous older adults

Greenhouse gas emissions from integrated urban drainage systems: where do we stand?

2018

As sources of greenhouse gas (GHG) emissions, integrated urban drainage systems (IUDSs) (i.e., sewer systems, wastewater treatment plants and receiving water bodies) contribute to climate change. This paper, produced by the International Working Group on Data and Models, which works under the IWA/IAHR Joint Committee on Urban Drainage, reviews the state-of-the-art and modelling tools developed recently to understand and manage GHG emissions from IUDS. Further, open problems and research gaps are discussed and a framework for handling GHG emissions from IUDSs is presented. The literature review reveals that there is a need to strengthen already available mathematical models for IUDS to take …