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RESEARCH PRODUCT
The EADC-ADNI Harmonized Protocol for manual hippocampal segmentation on magnetic resonance : Evidence of validity
Giovanni B. FrisoniClifford R. JackMichel J. GrotheMariangela LanfrediOliver MartinezMasami NishikawaMarileen PortegiesTravis StoubChadwich WardLiana G. ApostolovaRossana GanzolaDominik WolfMartina BocchettaFrederik BarkhofGeorge BartzokisCharles DecarliJohn G. CsernanskyLeyla Detoledo-morrellMirjam I. GeerlingsJeffrey KayeRonald J. KillianyStephane LehéricyHiroshi MatsudaCorinna BauerJohn O'brienLisa C. SilbertPhilip ScheltensHilkka SoininenStefan TeipelGunhild WaldemarAndreas FellgiebelJosephine BarnesMichael FirbankLotte GerritsenKristian S. FrederiksenWouter HennemanNikolai MalykhinJens C. PruessnerLei WangCraig WatsonHenrike WolfMony DeleonJohannes PantelClarissa FerrariPaolo BoscoYawu LiuPatrizio PasqualettiSimon DuchesneHenri DuvernoyMarina BoccardiMarilyn S. AlbertDavid BennetRichard CamicioliD. Louis CollinsBruno DuboisHarald HampelGregory PreboskeTom DenheijerChristofer HockWilliam JagustLeonore LaunerJerome J. MallerSusan MuellerPerminder SachdevAndy SimmonsPaul M. ThompsonPeter-jelle VisserTim SwihartLars-olof WahlundMichael W. WeinerBengt WinbladMelanie BlairEnrica Cavedosubject
MalePathologyDiagnostic criteriaEpidemiologyImage Processinggenetics [Alzheimer Disease]HippocampusFunctional LateralityImagingpathology [Alzheimer Disease]ddc:616.89methods [Magnetic Resonance Imaging]Computer-AssistedClinical trialsddc:150methods [Image Processing Computer-Assisted]ValidationImage Processing Computer-AssistedSegmentationHARPmedicine.diagnostic_testHealth PolicyOrgan SizeAlzheimer's diseaseMiddle Agedinstrumentation [Magnetic Resonance Imaging]Manual segmentationMagnetic Resonance ImagingPsychiatry and Mental healthMagnetic resonanceBiomedical ImagingManual segmentationFemalemethods [Neuroimaging]methods [Imaging Three-Dimensional]EADC-ADNI Working Group on The Harmonized Protocol for Manual Hippocampal Volumetry and for the Alzheimer's Disease Neuroimaging Initiativemedicine.medical_specialtyHippocampal volumetry; Magnetic resonance; Alzheimer's disease; Biomarkers; Diagnostic criteria; Enrichment; Clinical trials; Validation; Harmonized protocol; Standard operating procedures; Manual segmentationConcurrent validityClinical SciencesHarmonized protocolNeuroimagingArticleHippocampal volumetryCellular and Molecular NeuroscienceImaging Three-DimensionalDevelopmental NeuroscienceNeuroimagingClinical ResearchAlzheimer DiseasemedicineHumansddc:610AgedProtocol (science)ReproducibilityInternetbusiness.industryNeurosciencesReproducibility of ResultsMagnetic resonance imagingBrain DisordersStandard operating procedurespathology [Hippocampus]EnrichmentGeriatricsThree-DimensionalNeurology (clinical)Geriatrics and GerontologyAtrophyNuclear medicinebusinessBiomarkersdescription
BackgroundAn international Delphi panel has defined a harmonized protocol (HarP) for the manual segmentation of the hippocampus on MR. The aim of this study is to study the concurrent validity of the HarP toward local protocols, and its major sources of variance.MethodsFourteen tracers segmented 10 Alzheimer's Disease Neuroimaging Initiative (ADNI) cases scanned at 1.5 T and 3T following local protocols, qualified for segmentation based on the HarP through a standard web-platform and resegmented following the HarP. The five most accurate tracers followed the HarP to segment 15 ADNI cases acquired at three time points on both 1.5 T and 3T.ResultsThe agreement among tracers was relatively low with the local protocols (absolute left/right ICC 0.44/0.43) and much higher with the HarP (absolute left/right ICC 0.88/0.89). On the larger set of 15 cases, the HarP agreement within (left/right ICC range: 0.94/0.95 to 0.99/0.99) and among tracers (left/right ICC range: 0.89/0.90) was very high. The volume variance due to different tracers was 0.9% of the total, comparing favorably to variance due to scanner manufacturer (1.2), atrophy rates (3.5), hemispheric asymmetry (3.7), field strength (4.4), and significantly smaller than the variance due to atrophy (33.5%, P ConclusionsThe HarP has high measurement stability compared with local segmentation protocols, and good reproducibility within and among human tracers. Hippocampi segmented with the HarP can be used as a reference for the qualification of human tracers and automated segmentation algorithms. published
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2014-09-27 |