Search results for "wt"
showing 10 items of 5424 documents
Probabilistic classification of intracranial gliomas in digital microscope images based on EGFR quantity
2009
A glioma is a type of cancer occurring, in the majority of cases, in the brain. The World Health Organization (WHO) assigns a grade from I to IV to this tumor, with I being the least aggressive and IV being the most aggressive. In glioma cells of grade IV the Epidermal Growth Factor Receptors (EGFRs) are over expressed. In this paper we hypothesize that this overexpression occurs also for gliomas of grades I to III. Moreover, we present a medical study aiming to determine the correlation between the WHO classification and the EGFR quantity in glioma tissue. We define five quantity classes for EGFR. First, results of immunohistochemical staining on brain glioma slices, which visualize the EG…
PIK3R1 Mutations Cause Syndromic Insulin Resistance with Lipoatrophy
2013
International audience; Short stature, hyperextensibility of joints and/or inguinal hernia, ocular depression, Rieger anomaly, and teething delay (SHORT) syndrome is a developmental disorder with an unknown genetic cause and hallmarks that include insulin resistance and lack of subcutaneous fat. We ascertained two unrelated individuals with SHORT syndrome, hypothesized that the observed phenotype was most likely due to de novo mutations in the same gene, and performed whole-exome sequencing in the two probands and their unaffected parents. We then confirmed our initial observations in four other subjects with SHORT syndrome from three families, as well as 14 unrelated subjects presenting wi…
Managing Organizational Growth and Dynamic Complexity
2016
Managers, entrepreneurs and administrators are often reluctant to invest time in order to frame the future of their own organization. They may look too much focused on reducing the complexity of current management. The vision of the future they create in their own minds may remain unchanged even for many years, or may incrementally and ambiguously change, with no effort on learning, on perceiving the early symptoms of crises, and assessing the sustainability of organizational growth rate.
Investigating quality indicators of early childhood education programs in Kosovo, Ukraine and Finland
2020
The existing literature on early childhood education (ECE) quality is predominantly from the US or other developed countries. In low-and-middle-income countries (LMICs), systematic research on ECE ...
Spatial Convergence Clubs and the European Growth Process, 1980-1995
2003
Bernard Fingleton
Entrepreneurial capital and productive efficiency: the case of the Spanish regions
2019
The aim of this paper is to analyse the interrelation between entrepreneurial capital and productive efficiency of the Spanish regions while verifying the importance that business dynamics and entrepreneurial activity have on regional economic growth. For this purpose, data are used from the seventeen Spanish regions during the period 2003−2016. A multi-equation model is estimated that enables the analysis, on the one hand, of the existence of a causal relationship between business dynamics and entrepreneurial activity and, on the other hand, of these variables on the total factor productivity. The results lead to the conclusion that the entrepreneurial activity and the net creation of comp…
Defect incorporation in In-containing layers and quantum wells: Experimental analysis via deep level profiling and optical spectroscopy
2020
Abstract Recent studies demonstrated that the performance of InGaN/GaN quantum well (QW) light emitting diodes (LEDs) can be significantly improved through the insertion of an InGaN underlayer (UL). The current working hypothesis is that the presence of the UL reduces the density of non-radiative recombination centers (NRCs) in the QW itself: during the growth of the UL, surface defects are effectively buried in the UL, without propagating towards the QW region. Despite the importance of this hypothesis, the concentration profile of defects in the quantum wells of LEDs with and without the UL was never investigated in detail. This paper uses combined capacitance-voltage and steady-state pho…
Technical secondary education in Togo and Cameroon : Research Note
1990
International audience; This paper presents an evaluation of technical secondary education in Togo and Cameroon from the labor market perspective using tracer study data. Individuals face great difficulties in finding a job following training and the most common strategy used to avoid unemployment is to secure work in the informal sector. However, informal sector jobs provide low earnings and there appears to be a large discrepancy between an individual's expected earnings and actual earnings. One solution is to stimulate, and to enhance the role of, informal training through apprentice training centers.
Cytotoxicity and apoptosis induction by Fumaria officinalis extracts in leukemia and multiple myeloma cell lines
2021
Abstract Ethnopharmacological relevance Fumaria officinalis (Fumariaceae) is recorded in the Kurdish ethnobotany for various health problems. Aim of the study: In this study, the cytotoxic activity of F. officinalis extracts on two leukemia and nine multiple myeloma (MM) cell lines was investigated. Materials and methods: The cytotoxic and ferroptotic activity were examined by resazurin reduction assay. Flow cytometry, immunoblotting assay and fluorescence microscopy were used to measure cell cycle distribution, apoptosis, induction of reactive oxygen species (ROS), loss integrity of mitochondrial membrane potential (MMP) and autophagy. LC-ESI/MS was used to identify chemical constituents p…
Antitumor effects of dehydroxymethylepoxyquinomicin, a novel nuclear factor-kappaB inhibitor, in human liver cancer cells are mediated through a reac…
2009
Activation of the nuclear transcription factor-kappa B (NF-kappa B) has been implicated in liver tumorigenesis. We evaluated the effects of a novel NF-kappa B inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ), in two human liver cancer cell lines HA22T/VGH and HuH-6. DHMEQ treatment dose dependently decreased the DNA-binding capacity of the NF-kappa B p65 subunit, inhibited cell growth and proliferation, and increased apoptosis as shown by caspase activation, release of cytochrome c, poly(ADP-ribose) polymerase cleavage, and down-regulation of survivin. DHMEQ also induced a dose-dependent activation of mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signaling, …