Search results for "wt"
showing 10 items of 5424 documents
Chronic myeloid leukemia-derived exosomes promote tumor growth through an autocrine mechanism.
2014
Background Chronic myeloid leukemia (CML) is a clonal hematopoietic stem cell disorder in which leukemic cells display a reciprocal t(9:22) chromosomal translocation that results in the formation of the chimeric BCR-ABL oncoprotein, with a constitutive tyrosine kinase activity. Consequently, BCR-ABL causes increased proliferation, inhibition of apoptosis, and altered adhesion of leukemic blasts to the bone marrow (BM) microenvironment. It has been well documented that cancer cells can generate their own signals in order to sustain their growth and survival, and recent studies have revealed the role of cancer-derived exosomes in activating signal transduction pathways involved in cancer cell…
Conclusion: Towards Sustainable Development in the Philippines?
2017
For many years, the Philippine archipelago, as we hope to have shown throughout this book, has suffered from many ills, some related to its geography and natural environment, some to its major demographic trends, many also from its social, economic and political structures and choices and its early insertion within a globalized economy. Resources have been depleted or severely damaged (forests, soils, water, coral reefs, mangroves, fisheries). Environmental losses may be linked to extensive factors (economic and population growth) as well as intensive factors (unequal distribution and access to market resources) (Montes and Lim 1996). Everything is linked, such as climate change and poverty…
Strengthening the Social Capital in Rural Areas Through the Rural Renewal Program. A Case Study of Opole Voivodeship
2019
Opinions regarding the limited resources of the social capital in Poland are quite common. The country is particularly often referred to as a place with a lower level of organization of its inhabitants. Therefore, a change is necessary towards a greater activation of local communities and creation of social organizations aimed at solving local problems. The effective implementation of development programs may provide considerable support for the introduction of these changes. The Rural Renewal Program may serve as a particularly good example in this respect because the local community is not only the beneficiary, but mainly the initiator of the actions taken.
Continuous Professional Training and the Situation of Labour Market in Romania
2013
Abstract This study is part of a wider research carried out in recent years, in North-East Moldova – important socio-economic region of Romania – ancient Romanian culture and civilization hearth. It addresses issues of human capital development in the context of sustainable development of the City Suceava and Botosani. This study addresses the issue of human resource development, focusing on continuous training and employment. It is known that the development is based on the human resource, so there must be local responsabilities in terms of skilled labour and increase the adaptability of environamental changes. The results obtained from the research will reflect some of the practical steps…
Equity in REDD+: Varying logics in Tanzania
2015
Equity is frequently cited as one of the key design aspects of environmental governance regimes. In the context of Reduced Emissions from Deforestation and Forest Degradation (REDD+), a forest-based climate change mitigation instrument, the manner in which ‘equity’ is understood will be of critical importance for the impacts and acceptance of REDD + policies and initiatives. Whereas the concept has been extensively studied in the academic literature, references to equity in REDD + policy debates and documents are often vague, leaving room for various interpretations and modes of implementation. In our case study of the Tanzanian national REDD + policy domain, we provide a conceptual framewo…
Ways of Promoting Cultural Ecotourism for Local Communities in Sibiu Area
2014
Abstract Now, Romanian tourism is being confronted with problems of infrastructure and image, and this is a reason we consider that the chance of sustainable development of this area is being represented by promoting niche tourism, namely cultural ecotourism. In an age of globalization, the authentic cultural patrimony is that which makes the difference and represents an opportunity for sustainable development of local communities. The essence of sustainable development is represented by the harmonious integration of economic development, by responsible governing, by ensuring the social cohesion and community man - nature. By the attested value cultural ecotourism can become a touristic pro…
SOCIAL ENTREPRENEURSHIP IN THE SUSTAINABLE DEVELOPEMNT CONCEPT
2017
Sustainable development constitutes a paradigm which is to respond to the risks of our times (environmental, social and economic ones). It is based on the necessity to use resources in a way which will not deprive future generations of them. Such a development seeks to improve the quality of life of the community while maintaining social equality, diversity and the wealth of natural resources. It can be perceived as a broader social change which Jeremy Rifkin called “the third industrial revolution”, and whose symptoms can be seen today. Within the scope of this concept, there is the social entrepreneurship that, through the market activities, focuses on the social mission. Such a mission m…
Composite Indicator of Social Inclusion for European Countries
2013
Social inclusion is one of the key challenges of the European Union (EU) Sustainable Development Strategy. We use four indicators from EU policies to measure social inclusion for the 27 member countries of Europe. In particular, we aggregate the four indicators in a multiplicative composite indicator via a DEA-BoD approach with weights determined endogenously with proportion constraints. We obtain a score of social inclu- sion that allows us to grade the 27 EU countries from 2006 to 2010. In this way, we highlight the specific role played by the four indicators in determining improvements and deteriorations of social inclusion during the European phase of the financial and economic crisis.
Environmental education in Latvia
2012
This paper discusses the development of environmental education and education for sustainable development in Latvia since 1991. The article highlights best practices of environmental education in Latvia, which include curriculum and study materials development, active participation of various business enterprises in providing informal education, eco-school activities, etc. The objective of this paper is to share our experience with the international community and to promote a global dialogue in sustainable development.
Transportation and sustainable development in a mid-size French city, Dijon
2011
International audience