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Beneficios de la estimulación transcraneal por corriente directa en adultos mayores sanos y con trastorno neurocognitivo leve
2023
Muchos estudios señalan los beneficios que aporta la estimulación transcraneal con corriente directa (tDCS) en el rendimiento de las funciones cognitivas. La tDCS es una técnica de neuromodulación no invasiva y está enmarcada en las intervenciones no farmacológicas. En relación a su funcionamiento, mediante la tDCS se transmiten pequeñas cantidades de corriente a la corteza cerebral a través de dos o más electrodos colocados en el cuero cabelludo, alterando la excitabilidad de las neuronas al desplazar sus potenciales; este mecanismo logra facilitar o inhibir la actividad espontánea de las neuronas, produciéndose como consecuencia una modulación en la actividad neuronal y pudiendo conseguir…
Kant y Husserl: el problema de la subjetividad
1995
En este trabajo se lleva a cabo un estudio de las teorías kantiana y husserliana de la subjetividad en su doble faceta empírica y trascendental. Dicho estudio permite mostrar las profundas afinidades existentes entre los sistemas kantiano y husserliana y como esa doble dimensión de la subjetividad abre en la filosofía de Kant perspectivas fenomenológicas que alcanzarán su plenitud en la obra de Husserl.
CD40 activity on mesenchymal cells negatively regulates OX40L to maintain bone marrow immune homeostasis under stress conditions
2021
BackgroundWithin the bone marrow (BM), mature T cells are maintained under homeostatic conditions to facilitate proper hematopoietic development. This homeostasis depends upon a peculiar elevated frequency of regulatory T cells (Tregs) and immune regulatory activities from BM-mesenchymal stem cells (BM-MSCs). In response to BM transplantation (BMT), the conditioning regimen exposes the BM to a dramatic induction of inflammatory cytokines and causes an unbalanced T-effector (Teff) and Treg ratio. This imbalance negatively impacts hematopoiesis, particularly in regard to B-cell lymphopoiesis that requires an intact cross-talk between BM-MSCs and Tregs. The mechanisms underlying the ability of…
Mesenchymal Stem Cells Provide Better Results Than Hematopoietic Precursors for the Treatment of Myocardial Infarction
2010
Objectives The purpose of this study was to compare the ability of human CD34(+) hematopoietic stem cells and bone marrow mesenchymal stem cells (MSC) to treat myocardial infarction (MI) in a model of permanent left descendent coronary artery (LDA) ligation in nude rats. Background Transplantation of human CD34(+) cells and MSC has been proved to be effective in treating MI, but no comparative studies have been performed to elucidate which treatment prevents left ventricular (LV) remodelling more efficiently. Methods Human bone marrow MSC or freshly isolated CD34(+) cells from umbilical cord blood were injected intramyocardially in infarcted nude rats. Cardiac function was analyzed by echoc…
Dynamical Hadrons: Case Studies of Meson-Meson and Meson-Baryon Molecules and Triangle Singularities
2020
In this thesis we use various methods to study the interaction of hadrons. We focus on topics related to exotic hadrons, such as tetraquarks from meson-meson interaction, pentaquarks from meson-baryon, and also triangular singularities. We show how experimental data can be explained with our theoretical models, and make predictions that can be compared with future experiments. In chapter 1 we show our method to describe meson-meson interactions, known as chiral unitary approach, showing how the interaction of pseudoscalars generates the f0(500), f0(980) and a0(980), which appear in the two articles discussed in this chapter: that of the eta_c -> eta pi+ pi- decay, and that of the a0(980)-f0…
Translation of HTT mRNA with expanded CAG repeats is regulated by the MID1-PP2A protein complex.
2012
Expansion of CAG repeats is a common feature of various neurodegenerative disorders, including Huntington's disease. Here we show that expanded CAG repeats bind to a translation regulatory protein complex containing MID1, protein phosphatase 2A and 40S ribosomal S6 kinase. Binding of the MID1-protein phosphatase 2A protein complex increases with CAG repeat size and stimulates translation of the CAG repeat expansion containing messenger RNA in a MID1-, protein phosphatase 2A- and mammalian target of rapamycin-dependent manner. Our data indicate that pathological CAG repeat expansions upregulate protein translation leading to an overproduction of aberrant protein and suggest that the MID1-com…
The E3 Ubiquitin Ligase MID1 Catalyzes Ubiquitination and Cleavage of Fu
2014
Sonic Hedgehog (SHH)-GLI signalling plays an important role during embryogenesis and in tumorigenesis. The survival and growth of several types of cancer depend on autonomously activated SHH-GLI signalling. A protein complex containing the ubiquitin-ligase MID1 and protein phosphatase 2A (PP2A) regulates the nuclear localization and transcriptional activity of GLI3, a transcriptional effector molecule of SHH, in cancer cell lines with autonomously activated SHH signalling. However, the exact molecular mechanisms that mediate the interaction between MID1 and GLI3 remained unknown. Here, we show that MID1 catalyses the ubiquitination and proteasomal cleavage of the GLI3-regulator Fu. Our data…
Tolerance of Whitefish (Coregonus Lavaretus) Early Life Stages to Manganese Sulfate is Affected by the Parents
2017
European whitefish (Coregonus lavaretus) embryos and larvae were exposed to 6 different manganese sulfate (MnSO4) concentrations from fertilization to the 3-d-old larvae. The fertilization success, offspring survival, larval growth, yolk consumption, embryonic and larval Mn tissue concentrations, and transcript levels of detoxification-related genes were measured in the long-term incubation. A full factorial breeding design (4 females × 2 males) allowed examination of the significance of both female and male effects, as well as female–male interactions in conjunction with the MnSO4 exposure in terms of the observed endpoints. The MnSO4 exposure reduced the survival of the whitefish early li…
Metas evolutivas y representaciones del futuro en personas mayores sanas y con enfermedades crónicas
2012
Los seres humanos somos organismos intencionales, orientados hacia metas, perfilados hacia el futuro, poseemos ilusiones, expectativas, esperanzas, temores o amenazas que orientan nuestras acciones, dan significado e influyen la vida, para que seamos, hasta cierto punto, arquitectos del propio desarrollo. Las metas, su mantenimiento y cambio en diferentes situaciones, son un medio de adaptación fundamental a las diferentes circunstancias y contextos que nos toca vivir. Esa estructura de metas va ajustándose, para aprovechar las oportunidades que están a nuestro alcance o mitigar el impacto de los obstáculos y adversidades. El envejecimiento, como proceso generalmente asociado a una mayor pr…
Consequences of analgesics use in early pregnancy: Results of tests on mice.
2019
International audience; Self-medication during pregnancy continues to be an issue in developing countries due topoor medical education. The most commonly used drugs are analgesics, mainlyacetaminophen (paracetamol, APAP) and, to a lesser extent, ketoprofen (KPF). The aim of thestudy was to establish whether there are consequences of accidental use of these two drugsduring early embryogenesis. The experimental study was performed on 30 pregnant whitemice, divided into three groups: a first group to which APAP was administered, a secondgroup to which KPF was administered, and group 3 as a control group. At delivery, the babymice were examined, and after their first parturition, they were take…