Search results for "zola"
showing 10 items of 271 documents
Diuretic Strategies in Acute Heart Failure and Renal Dysfunction: Conventional vs Carbohydrate Antigen 125-guided Strategy. Clinical Trial Design
2017
Abstract Introduction and objectives The optimal treatment of patients with acute heart failure (AHF) and cardiorenal syndrome type 1 (CRS-1) is far from being well-defined. Arterial hypoperfusion in concert with venous congestion plays a crucial role in the pathophysiology of CRS-I. Plasma carbohydrate antigen 125 (CA125) has emerged as a surrogate of fluid overload in AHF. The aim of this study was to evaluate the clinical usefulness of CA125 for tailoring the intensity of diuretic therapy in patients with CRS-1. Methods Multicenter, open-label, parallel clinical trial, in which patients with AHF and serum creatinine ≥ 1.4 mg/dL on admission will be randomized to: a) standard diuretic str…
Salts of 5-amino-2-sulfonamide-1,3,4-thiadiazole, a structural and analog of acetazolamide, show interesting carbonic anhydrase inhibitory properties…
2015
Three salts of 5-amino-2-sulfonamide-1,3,4-thiadiazole (Hats) were prepared and characterized by physico-chemical methods. The p-toluensulfonate, the methylsulfonate, and the chlorhydrate monohydrate salts of Hats were evaluated as carbonic anhydrase (CA, EC 4.2.1.1) inhibitors (CAIs) and as anticonvulsants and diuretics, since many CAIs are clinically used as pharmacological agents. The three Hats salts exhibited diuretic and anticonvulsant activities with little neurotoxicity. The human (h) isoforms hCA I, II, IV, VII, IX, and XII were inhibited in their micromolar range by these salts, whereas pathogenic beta and gamma CAs showed similar, weak inhibitory profiles.
High-performance liquid chromatographic determination of diuretics in urine by micellar liquid chromatography.
1992
The use of micellar liquid chromatography for the determination of diuretics in urine by direct injection of the sample into the chromatographic system is discussed. The retention of the urine matrix at the beginning of the chromatograms was observed for different sodium dodecyl sulphate (SDS) mobile phases. The eluent strengths of a hybrid SDS-methanol micellar mobile phase for several diuretics were compared and related to the stationary phase/water partition coefficient with a purely micellar mobile phase. The urine band was appreciably narrower with a mobile phase of 0.05 M SDS-5% methanol (v/v) at 50 degrees C (pH 6.9). With this mobile phase the determination of bendroflumethiazide an…
Metody izolacji oraz identyfikacji związków lotnych w miodach odmianowych
2016
Preliminary approach towards construction of peptide libraries as potential tools for diagnosis of malignant thyroid tumors
2006
Nowotwory złośliwe tarczycy należą do najczęstszych nowotworów złośliwych układu endokrynnego. Poprawa wyników leczenia wiąże się z postępem wczesnej diagnostyki raka. Celem niniejszych badań jest poszukiwanie wskaźników nowotworowych za pomocą bibliotek peptydowych umieszczonych na podłożu z bibuły. Materiał i metody: Analizie poddano tkanki pobrane od 6 pacjentów: 4 z rakiem brodawkowatym tarczycy, 1 z nowotworem pęcherzykowym oraz 1 pacjenta z rakiem oksyfilnym. Badania wykonywano z wykorzystaniem bibliotek peptydowych lipofilowych, porównując tkankę zdrową i chorą oraz oceniając zmianę zabarwienia w poszczególnych bibliotekach. Wyniki: Wstępne wyniki wskazują, że biblioteki peptydowe mo…
Du « socialisme de cœur » zolien, ou comment être considéré en même temps comme « socialiste » et « ennemi du peuple »
2020
When Germinal was published in 1885, the critic classified Zola as a “socialist” writer. The author himself used this adjective many times referring to his work. At the same time, he didn’t know Marxism and was a resolute opponent to revolution, equality and the government by the people. The paper aims to explain some aspects of Zola’s “socialism” taking into account his origins, his youth experiences and the evolution of his works. This might help to understand the particular meaning done to the term by the writer. Suite à la publication de Germinal en 1885, la critique a classé Zola comme un écrivain « socialiste ». Le romancier lui-même a utilisé ce qualificatif plusieurs fois en parlant…
"Thérèse Raquin" d'Émile Zola : la notion de tempérament entre l'héritage antique et l'apport de la physiologie du XIXe siècle
2020
Therese Raquin, Zola’s first important work, is based on the modern version of the old physiological theory of “temperaments”, e.g. the combination of four cardinal “humours” that determine a man’s physical and mental constitution. Through the story of two murderers, an adulterous woman and her lover who kill the woman’s husband, the author shows the mutual influence of two temperaments considered in the 19th century as more important than all the others: sanguine and melancholic (or nervous). The novel intends to “verify” a theory dealing with the consequences of each type of temperament for people’s behaviour, their relationships and their internal life.
Petro-archaeology of Gallo-Roman lime mortar. Attempt to reconstruction and interpretation of the “chaînes opératoires”: from material to ancient cra…
2003
Petro-archaeological research on Gallo-Roman lime mortars is based on a simple analytical methodology: observations with optical microscopy in transmission, which brings us a maximum of data about the material and the various stages of the “chaîne opératoire”. This work enabled us to draw the general features of the craftmanship (common practices of the ancient structores and tectores), to establish the relations between mortar composition and its “primary” and “secondary” architectural function, then to perceive what are the markers and motivations of the formula adaptations. The importance of the geological environment is shown, because it induces economic and technical choices, requiring…
Prenatal exposure to diazepam and alprazolam, but not to zolpidem, affects behavioural stress reactivity in handling-naïve and handling-habituated ad…
2002
A gentle long-lasting handling produces persistent neurochemical and behavioural changes and attenuates the impairment in the behavioural reactivity to novelty induced by the prenatal exposure to diazepam (DZ) in adult male rat progeny. This study investigated the consequences of a late prenatal treatment with three GABA/BDZ R agonists (DZ) alprazolam (ALP) and zolpidem (ZOLP)), on different stress-related behavioural patterns, in non-handled (NH), short-lasting handled (SLH) and long-lasting handled (LLH) adult male rats exposed to forced swim test (FST), acoustic startle reflex (ASR) and Vogel test (VT). The effects on motor activity were evaluated in the open field and in the Skinner box…
Le "manteau de la religion" couvrant le vide : la critique du catholicisme dans "Comment on meurt" et "Comment on se marie" d’Émile Zola
2019
The paper discusses Emile Zola’s critical opinion about the Catholicism revealed in two novellas, Comment on meurt (Death) and Comment on se marie (Modern marriage). The two texts, depicting crucial moments of human existence in various social classes, show the general lack of faith within the French society of the Second Empire and the superficial character of religious rituals considered as a simple element of tradition. The attitude of the clergy, hypocritical and greedy, is an important factor of this situation.