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AUTHOR
Juan M. Falcón-pérez
The future of Extracellular Vesicles as Theranostics – an ISEV meeting report
ABSTRACT The utilization of extracellular vesicles (EVs) in clinical theranostics has rapidly advanced in the past decade. In November 2018, the International Society for Extracellular Vesicles (ISEV) held a workshop on “EVs in Clinical Theranostic”. Here, we report the conclusions of roundtable discussions on the current advancement in the analysis technologies and we provide some guidelines to researchers in the field to consider the use of EVs in clinical application. The main challenges and the requirements for EV separation and characterization strategies, quality control and clinical investigation were discussed to promote the application of EVs in future clinical studies.
Biological properties of extracellular vesicles and their physiological functions
The authors wish to thank Dr R Simpson and Dr D Taylor for critical reading of the manuscript and acknowledge the Horizon 2020 European Cooperation in Science and Technology programme and its support of our European Network on Microvesicles and Exosomes in Health & Disease (ME-HaD; BM1202 www.cost.eu/COST_Actions/bmbs/Actions/BM1202). In the past decade, extracellular vesicles (EVs) have been recognized as potent vehicles of intercellular communication, both in prokaryotes and eukaryotes. This is due to their capacity to transfer proteins, lipids and nucleic acids, thereby influencing various physiological and pathological functions of both recipient and parent cells. While intensive invest…
A novel community driven software for functional enrichment analysis of extracellular vesicles data
Bioinformatics tools are imperative for the in depth analysis of heterogeneous high-throughput data. Most of the software tools are developed by specific laboratories or groups or companies wherein they are designed to perform the required analysis for the group. However, such software tools may fail to capture "what the community needs in a tool". Here, we describe a novel community-driven approach to build a comprehensive functional enrichment analysis tool. Using the existing FunRich tool as a template, we invited researchers to request additional features and/or changes. Remarkably, with the enthusiastic participation of the community, we were able to implement 90% of the requested feat…
First Symposium of “Grupo Español de Investigación en Vesículas Extracelulares (GEIVEX)”, Segovia, 8–9 November 2012
On the 8th and 9th of November, 71 scientists working in the field of extracellular vesicles from different laboratories in Spain met together in Segovia to present and discuss their research advances in this transformative and catalytic new field in translational biomedicine. (Published: 30 January 2013) Citation: Journal of Extracellular Vesicles 2013, 2 : 20256 - http://dx.doi.org/10.3402/jev.v2i0.20256